A5013241694- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Soft Robotics and Applications
- Nanoparticle-Based Drug Delivery
- Saffron Plant Research Studies
- Nanoplatforms for cancer theranostics
- Surgical Simulation and Training
- Augmented Reality Applications
- Phytochemical and Pharmacological Studies
- Phytochemical Studies and Bioactivities
- Advancements in Transdermal Drug Delivery
- Bioactive natural compounds
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
- Steroid Chemistry and Biochemistry
- Heat shock proteins research
- Mesoporous Materials and Catalysis
- Phytochemicals and Antioxidant Activities
- Amoebic Infections and Treatments
- Hepatitis C virus research
- Image Processing Techniques and Applications
- Robotic Path Planning Algorithms
Shenyang Pharmaceutical University
2013-2024
Zhejiang University of Technology
2022
China Automotive Technology and Research Center
2022
Tianjin University
2011-2012
Kobe Gakuin University
2005
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying efficacy and underlying safety problems have limited clinical application. Herein, inspired by probiotic Escherichia coli strain Nissle 1917, probiotic-derived outer membrane vesicles (OMVs) are found to serve as an effective therapeutic platform for treatment inflammatory bowel disease (IBD). To further enhance effect, OMV-encapsulating manganese dioxide nanozymes constructed, named nanoprobiotics,...
A commercial albumin-bound paclitaxel nano-formulation has been considered a gold standard against breast cancer. However, its application still restricted unfavorable pharmacokinetics and the immunogenicity of exogenous albumin carrier. Herein, we report an tumor redox-responsive prodrugs nano-delivery strategy. Using diverse linkages (thioether bond disulfide bond), (PTX) was conjugated with albumin-binding maleimide (MAL) functional group. These pure PTX could self-assemble to form...
Heat shock proteins (HSPs), most of which are molecular chaperones, highly conserved produced by cells under physiological stress or pathological conditions. HSP60 (57–69 kDa) can promote inhibit cell apoptosis through different mechanisms, and its abnormal expression is also related to tumour metastasis drug resistance. In recent years, has received increasing attention in the field cancer research due potential as a diagnostic prognostic biomarker therapeutic target. However, types cancer,...
Calcium-induced alginate gel bead (Alg-Ca) coated with an hydrolysate(Alg), e.g. the guluronic acid block (GB) was prepared and model drug, hydrocortisonerelease profiles were investigated under simulated gastrointestinal conditions. Theirmolecular weights one sixth or tenth that of Alg diffraction patterns thehydrolysates resembled Alg. The drug release rate from Alg-Ca GBapparently lowered than (coating-free) in gastric juice (pH1.2). And thecoating did not resist disintegration intestinal...
The objective of this work is to construct a nanosuspension drug delivery system probucol, BCS II drug, in order improve its dissolution and oral bioavailability. wet milling procedure using planetary beads-milling equipment was utilized grind the raw probucol ultrafine nanoparticle/nanocrystal aqueous suspension that further solidified by freeze-drying process. Cellulose derivatives different substitution groups molecular weights, including HPMC, HPC, MC, were evaluated as primary...
Abstract Background Minimally invasive surgery (MIS) robots are commonly used in hospitals and medical centres. However, currently available robotic systems very complicated huge, greatly raising system costs the requirements of operating rooms. These disadvantages have become major impediments to expansion MIS robots. Methods An integrated is proposed based on analysis advantages different In system, master manipulators, slave image display device control been designed as a whole. Modular...
A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures elucidated by spectral methods. This is first time that arginine has been found to be involved in biosynthesis bufotenines parotid toad. The cytotoxic activities these compounds have assayed against A375 A549 cell lines MTT method; however, they showed no activities.
A new indole alkaloid N'-formylserotonin (1), along with five known alkaloids N'-methylserotonin (2), 5-hydroxy-1H-indole-3-carbaldehyde (3), N-acetylserotonin (4), 6-hydroxy-1-oxo-3,4-dihydro-β-carboline (5), and bufoserotoin C (6), were isolated from the water extract of traditional Chinese medicine Chansu. Their structures elucidated on basis spectral analyses. The cytotoxicities 1-6 against human lung adenocarcinoma epithelial cells A549 tested using MTT method. Compound 6 exhibited...
Crocetin (CRT), an active compound isolated from saffron, exhibits several pharmacological activities, including anti-tumor and immune-regulatory is effective against myocardial ischemia coronary heart disease; however, its low stability solubility limit clinical application. Therefore, we investigated CRT inclusion complexes (ICs) with three cyclodextrins-α-CD, HP-β-CD, γ-CD-suitable for oral administration prepared using ultrasonic method. Fourier transform infrared spectroscopy powder...
Objectives: The aim of this study was to ascertain the potential toxicity perilla seed oil-based lipid emulsion (POLE) caused by phytosterols and confirm efficacy technique for removing from oil, evaluate safety a low phytosterol POLE in long-term tolerance dogs.Methods: A comparison between soybean oil (Intralipid group A) with high (group B) versus C) levels made regard their effects on general condition, hematological biochemical parameters, urinalysis histopathological changes nine dogs...
Port placement planning is an important aspect in minimally invasive robotic surgery. Proper port can improve the quality and efficiency of This paper proposes a new concise method based on workspace surgery required. Robotic-assisted cholecystectomy selected to expound this method. Optimal robotic-assisted discussed simulated through
Panax quinquefolium saponin (PQS) composed of 45% pseudo-ginsenoside F11 (PF11), is a natural mixture sterol compounds obtained from the American ginseng plant, having numerous promising benefits for health. However, low solubility and permeability limit development PQS as therapeutic agent oral administration. In this study, liposomes (PQS-Lips) were prepared by thin layer hydration, an in situ single-pass intestinal perfusion (SPIP) model was used to verify improvement membrane PQS-Lips....
Resibufogenin (RBG) is a natural medicinal ingredient with promising cardiac protection and antitumor activity. However, poor solubility severe gastric mucosa irritation restrict its application in the pharmaceutical field. In this study, inclusion complex of RBG β-cyclodextrin (β-CD) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared using co-evaporation method, molar ratio to CD determined be approximately 1:2 by continuous variation plot for both CDs. The formation complexes between...