A5051429814- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- Protease and Inhibitor Mechanisms
- interferon and immune responses
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Heme Oxygenase-1 and Carbon Monoxide
- Collagen: Extraction and Characterization
- Silymarin and Mushroom Poisoning
- Silk-based biomaterials and applications
- Inflammasome and immune disorders
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Proteoglycans and glycosaminoglycans research
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Periodontal Regeneration and Treatments
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Bone Tissue Engineering Materials
- Peptidase Inhibition and Analysis
Japan Institute of Leather Research
2015-2024
Kagoshima City Hospital
2015
Skeletal muscle regeneration is a complicated process, requiring the proliferation, migration and differentiation of myoblasts whose processes are highly regulated by extracellular matrix (ECM) surrounding tissues in vivo. However, effects respective ECM components on regulation myoblast behaviors unknown. In this study, we report effect collagen I, major component tissue popular food supplement, mouse C2C12 as well underlying mechanisms. Collagen I (col 1) enhances myogenic cells, but has...
Activin A, a member of the transforming growth factor-β family, plays important roles in hormonal homeostasis and embryogenesis. In this study, we produced recombinant human activin A examined its abilities to bind extracellular matrix proteins. Recombinant expressed 293-F cells was purified as complexes mature dimeric with pro-region. Among panel proteins tested, bound perlecan agrin, but not laminins, nidogens, collagens I IV, fibronectin, nephronectin. The binding inhibited by heparin...
Mammary analogue secretory carcinoma (MASC) with an ETS variant gene 6 (ETV6)-neurotrophic tyrosine kinase receptor type 3 (NTRK3) translocation is a newly described of salivary gland cancer. It known that overexpression signal transducer and activator transcription 5a (STAT5a) occurs in the breast MASC, STAT5a expression may be related to ETV6-NTRK3 translocation. was hypothesized phosphorylated 5 (p-STAT5) might specifically expressed MASC gland.The p-STAT5 mammaglobin (MMG) examined...
Extracellular matrix (ECM) has a marked influence on adipose tissue development. Adipose formation is initiated with proliferation of preadipocytes and migration before undergoing further differentiation into mature adipocytes. Previous studies showed that collagen I (col I) provides good substratum for 3T3-L1 to grow migrate. However, it remains unclear whether how col regulates adipogenic preadipocytes. This study reports lipid accumulation, representing in vitro adipogenesis the or mouse...
Keratinocyte line cells HaCaT and FEPE1L-8 are used for skin model with type I collagen fibrils (gels). For this purpose, not only differentiation but also regulation of proliferation on gels by exogenous calcium concentration is important. When low, primary keratinocyte repressed eventually induced to apoptosis gels. The suppressed increasing in the medium. That is, higher necessary survival than that dish surface culture. Meanwhile much causes cell inhibition proliferation. optimal...