A5085085885- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Cell Adhesion Molecules Research
- Neuropeptides and Animal Physiology
- Calpain Protease Function and Regulation
- Electromagnetic Fields and Biological Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacological Receptor Mechanisms and Effects
- Genetic and Kidney Cyst Diseases
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Retinal Imaging and Analysis
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aquatic Ecosystems and Phytoplankton Dynamics
- Mitochondrial Function and Pathology
- Clusterin in disease pathology
- Bacillus and Francisella bacterial research
- Single-cell and spatial transcriptomics
- Gestational Trophoblastic Disease Studies
- Tryptophan and brain disorders
- Healthcare and Venom Research
Shandong Agricultural University
2025
First Affiliated Hospital of Harbin Medical University
2021-2024
Harbin Medical University
2021-2024
Southwest University
2023
State Key Laboratory of Silkworm Genomic Biology
2023
Chinese Academy of Sciences
2020
Northeastern University
2020
Shenyang Pharmaceutical University
2011-2019
Sichuan University
2019
Chengde Medical University
2012-2019
ABSTRACT Pertactin (PRN) is an autotransporter protein produced by all members of the Bordetella bronchiseptica cluster, which includes B. pertussis , parapertussis and . It a primary component acellular vaccines, anti-PRN antibody titers correlate with protection. In vitro studies have suggested that PRN functions as adhesin RGD motif located in center passenger domain important for this function. Two regions contain sequence repeats (region 1 [R1] R2) show polymorphisms among strains been...
Zeaxanthin, a type of carotenoid, has been proven to exhibit anti-lipogenesis effect; however, the detailed mechanism this effect is less known. Herein, we evaluated effects zeaxanthin on inhibition adipogenesis in 3T3-L1 adipocytes and obesity high-fat diet fed C57BL/6J mice. Zeaxanthin significantly decreased intracellular lipid content dose-dependent manner (5-15 μM) without causing cytotoxicity. In high-fat-diet-induced obese mice, oral administration 20 mg kg-1 attenuated progression...
ABSTRACT Plant height is a crucial agronomic trait affecting lodging resistance and yield. The mediator subunit, such as MED25, plays role in regulating plant growth development. This study elucidated the mechanistic of OsMED25, an integral subunit transcriptional coactivator complex, regulation height. Phenotypic results indicated significant reduction OsMED25‐RNAi line. Further analysis that GA 1 3 levels were significantly reduced, expression gibberellin biosynthesis‐related genes...
Summary Modification of specific G ram‐negative bacterial cell envelope components, such as capsule, O ‐antigen and lipid A , are often essential for the successful establishment infection. F rancisella species express molecules with unique characteristics involved in circumventing host defences, which significantly contribute to their virulence. I n this study, we show that NaxD a member highly conserved YdjC superfamily, is deacetylase required an important modification outer membrane...
The effects of xanthoceraside on learning and memory impairment were investigated the possible mechanism associated with protection mitochondria was also preliminarily explored in Alzheimer's disease (AD) mice model induced by intracerebroventricular (i.c.v.) injection Aβ1-42. results indicated that (0.08-0.32 mg/kg) significantly improved Morris water maze test Y-maze test. Xanthoceraside reversed aberrant decrease ATP levels attenuated abnormal increase ROS both cerebral cortex hippocampus...
Xanthoceraside, a novel triterpenoid saponin, has been found to attenuate learning and memory impairments in AD animal models. However, whether xanthoceraside positive effect on synaptic morphology remains unclear. Herein, we evaluated the effects of abnormalities structure APP/PS1 transgenic mice. The behavioral experiments demonstrated that attenuated imaginal spatial impairments, improved social interaction. Transmission electron microscopy Golgi staining showed ameliorated synapse...
In this study, we investigated the effects of mobile phone radiation on spatial learning, reference memory, and morphology in related brain regions. After near-field (0.52-1.08 W/kg) was delivered to 8-week-old Wistar rats 2 hours per day for 1 month, behavioral changes were examined using Morris water maze. Compared with sham-irradiated rats, irradiated exhibited impaired performance. Morphological by examining synaptic ultrastructural hippocampus. Using physical dissector technique, number...
Xanthoceraside, a saponin extracted from the husks of Xanthoceras sorbifolia Bunge, suppresses inflammation and oxidative stress. However, antitumor properties xanthoceraside as well its mechanism action remain unclear. Therefore, we proposed to investigate potential anticancer property. In this study, viability cells was measured by MTT assay. Cell cycle mitochondrial membrane were flow cytometry, expressions procaspase-9, procaspase-3, Cyto.c, Apaf-1, Bcl-2, Bcl-xL, Bad, p53,...