A5103247885- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- RNA Interference and Gene Delivery
- Plant-Microbe Interactions and Immunity
- CRISPR and Genetic Engineering
- Micro and Nano Robotics
- Insect Resistance and Genetics
- Entomopathogenic Microorganisms in Pest Control
- Powdery Mildew Fungal Diseases
- MicroRNA in disease regulation
- Insect Pest Control Strategies
- Toxin Mechanisms and Immunotoxins
- Nanoparticle-Based Drug Delivery
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Viral-associated cancers and disorders
- Stress Responses and Cortisol
- Brucella: diagnosis, epidemiology, treatment
- Biochemical and Structural Characterization
- Horticultural and Viticultural Research
- Characterization and Applications of Magnetic Nanoparticles
- Ocular Infections and Treatments
- Animal Diversity and Health Studies
- Electrochemical Analysis and Applications
- Cholesterol and Lipid Metabolism
Zhengzhou University
2020-2025
Ministry of Education of the People's Republic of China
2022-2025
Fujian Agriculture and Forestry University
2021-2025
First Affiliated Hospital Zhejiang University
2022-2025
Guangzhou Medical University
2024
Xinjiang University
2024
Zhejiang University
2022
Henan University
2022
Chinese Academy of Agricultural Sciences
2020-2021
Cotton Research Institute
2020-2021
Oral drug delivery systems have great potential to treat colorectal cancer (CRC). However, the efficiency is restricted by limited CRC-related intestine positioning and dense mucus barrier. Here, we present a biological chemotaxis-guided self-thermophoretic nanoplatform that facilitates precise intestinal autonomous penetration. The introduces asymmetric platinum-sprayed mesoporous silica achieve movement in mucus. Furthermore, inspired intense interaction between pathogenic microbes CRC,...
Abstract Colorectal cancer (CRC) is the second most common cause of incidence worldwide. Oral drug delivery systems (ODDS) have shown great promise for CRC therapy, but efficiency still challenged by dense intestinal mucus barrier and nonspecific interception abnormally proliferated pathogenic bacteria. Herein, self‐thermophoretic nanoparticles (CTPB) presented to enhance penetration reduce bacteria in efficient delivery. The nanoplatform introduces hollow mesoporous copper sulfide...
To improve the delightful flavor of mulberry wine through semi-artificial inoculation fermentation with Saccharomyces cerevisiae, we studied dynamics change microbiota, along physicochemical properties and metabolite profiles their interaction relationship during process. The abundance lactic acid bacteria (Weissella, Lactobacillus, Fructobacillus, Pediococcus) increased significantly fermentation, while yeasts gradually established dominance. inter-kingdom network dominant genera analysis...
In this study, a rapid, inexpensive, and accurate colorimetric sensor for detecting psychrophilic bacteria was designed, comprising gold (Au) nanoparticles (NPs) modified by d-amino acid (D-AA) as color-metric probes. Based on the aggregation of Au NPs induced bacteria, noticeable color shift occurred within 6 h. Depending various metabolic behaviors to different D-AA, four primary in raw milk were successfully distinguished learning response patterns. Furthermore, quantification single...
A well-designed DNA tetrahedron based biosensor (DTB) has been employed for imaging and detection of argonaute2 (Ago2), a key RNA interference (RNAi) protein. This DTB mainly contains two segments: as frame photoinduced electron-transfer (PET) pair fluorescence transducer. The tetrahedral nanostructure is assembled with four nucleic acid strands. On one edge, strand forms hairpin structure (RNA sequence) which implanted in the complementary double-strand DNAs, PET pairs, DNA/silver...
Verticillium wilt is a plant vascular disease caused by the soilborne fungus dahliae that severely limits cotton production. In previous study, we screened Bacillus cereus YUPP-10, an efficient antagonistic bacterium, to uncover mechanisms for controlling verticillium wilt. Here, report novel antimicrobial cyclodextrin glycosyltransferase (CGTase) from YUPP-10. Compared other CGTases, six different conserved domains were identified, and mutants constructed gene splicing with overlap...
Gestational trophoblastic neoplasia (GTN) refers to malignant diseases originating from placental trophoblast cells. Despite high complete remission rates with standard treatments, the adverse effects of chemotherapy, variation in treatment regimens, and psychological impact on patients significantly influence prognosis. This study aims identify factors influencing time serum human chorionic gonadotropin (hCG) negativization, thereby contributing optimization patient management strategies....
Abstract Bacillus thuringiensis is widely employed for biological control. It can effectively suppress populations of various mosquito species, including Aedes aegypti . However, the precise mechanism underlying action cry toxin secreted by on Ae. remains elusive. In this study, we investigated one binding receptors toxin, aminopeptidase N. Through comprehensive bioinformatics analysis involving whole-genome screening, genetic mapping, structural characterization, phylogenetic analysis, and...
Powdery mildew is one of the most important fungal pathogen diseases. The genome barley fungus, Blumeria graminis f. sp. hordei ( Bgh ), encodes a large number candidate secreted effector proteins (CSEPs). So far, function and mechanism CSEPs remain largely unknown. Here, we identify CSEP0027, member family 41, triggering cell death in Nicotiana benthamiana . CSEP0027 contains functional signal peptide (SP), verified by yeast secretion assay. We show that promotes virulence infection using...
Verticillium wilt, mainly caused by a soil-inhabiting fungus dahliae, can seriously reduce the yield and quality of cotton. The complex mechanism underlying cotton resistance to wilt remains largely unknown. In plants, reactive oxygen species (ROS) mediated Rbohs is one earliest responses plants biotic abiotic stresses. our previous study, we performed time-course phospho-proteomic analysis roots resistant susceptible varieties in response V. found early differentially expressed protein...
To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan association with human immunodeficiency virus (HIV), herpesvirus 8 (HHV8) Epstein-Barr (EBV).We investigated retrospectively 26 cases a median age 76.5. Only one (4%) patient was infected HIV. Cytologically, all cells revealed typical immunoblastic to plasmablastic morphology. Immunohistochemically, HHV8 positive eight (32%) tumours negative 17 (68%) cases. All 23 tested examined were...
Radiotherapy for rectal cancer has received increasing research attention in recent years; however, no bibliometric assessment been conducted on the progress of this field. This study aimed to visualize evolution and emerging hotspots field radiotherapy using methods. Data were collected from Web Science Core Collection database, including countries, institutions, authors, keywords, co-citations references, CiteSpace software was used analysis. A total 5,372 publications cancer, published...
Abstract The powdery mildew fungi secrete numerous Candidate Secreted Effector Proteins (CSEPs) to manipulate host immunity during infection of plants. However, the function most these CSEPs in cell death suppression has not yet been established. Here, we identified several from Blumeria graminis f. sp. hordei ( Bgh ) that have potential suppress BAX- and Nt MEK2 DD -triggered Nicotiana benthamiana . We further characterized two effector candidates, CSEP0139 CSEP0182, family six thirty-two,...
Raw camel milk is generally contaminated with varied microbiota, including antibiotic–resistant bacteria (ARB), that can act as a potential pathway for the spread of antibiotic resistance genes (ARGs). In this study, high–throughput quantitative PCR and 16S rRNA gene–based Illumine sequencing data were used to establish comprehensive understanding resistome its relationship bacterial community in Bactrian from Xinjiang. A total 136 ARGs up 1.33 × 108 ARG copies per gram identified, which...
The insecticidal Cry4Ba and Cry11Aa crystal proteins from Bacillus thuringiensis subsp. israelensis (Bti) are highly toxic to Ae. aegypti larvae. glycosylphosphatidylinositol (GPI)-anchored APN was identified as an important membrane-bound receptor for multiple Cry toxins in numerous Lepidoptera, Coleoptera, Diptera insects. However, there is no direct molecular evidence link of Bti toxicity vivo. In this study, two Cry4Ba/Cry11Aa-binding GPI-APN isoforms (AeAPN1 AeAPN2) were individually...