A5101696030- Ferroptosis and cancer prognosis
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- PARP inhibition in cancer therapy
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Viral Infections and Outbreaks Research
- Ethics and Legal Issues in Pediatric Healthcare
- DNA Repair Mechanisms
- Biliary and Gastrointestinal Fistulas
- Esophageal and GI Pathology
- Disaster Response and Management
- Cancer-related molecular mechanisms research
- Abdominal Surgery and Complications
- Cellular Mechanics and Interactions
- Antibiotic Use and Resistance
- Cholesterol and Lipid Metabolism
- Brain Metastases and Treatment
- S100 Proteins and Annexins
- Drug Transport and Resistance Mechanisms
- FOXO transcription factor regulation
- Lipid metabolism and biosynthesis
- Hedgehog Signaling Pathway Studies
Henan University Huaihe Hospital and Huaihe Clinical Institute
2009-2024
First Affiliated Hospital of Henan University
2023
Henan University
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Sun Yat-sen University
2014-2020
The First Affiliated Hospital, Sun Yat-sen University
2014-2020
The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and analyze its association with the prognosis GC patients. Immunohistochemical staining, Western blotting, quantitative reverse-transcriptase polymerase chain reaction were performed MLKL tissue 117 Clinicopathological characteristics survival data retrospectively analyzed discover clinical importance expression. chi-square test used relationship between clinicopathological...
Sonic hedgehog (SHH) plays critical roles in cell growth and development. Tumor cells express SHH, which can promote proliferation epithelial-to-mesenchymal transition. However, the autocrine SHH pathway has not been described gastric cancer. The aim of this study was to explore molecular mechanisms underlying signaling cancer cells. expression assessed using immunohistochemistry results were compared with clinicopathologic parameters, including survival. Using lines, we measured mRNA...
// Chang-Jiang Qin 1,2 , Xin-Ming Song 1 Zhi-Hui Chen Xue-Qun Ren 2 Kai-Wu Xu Hong Jing 3 and Yu-Long He Department of Gastrointestinal Pancreatic Surgery, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, China Huaihe Hennan Kaifeng, Pathology, Correspondence to: Song, email: Keywords : XRCC2, rectal cancer, preoperative radiotherapy, radioresistance Received April 21, 2015 Accepted July 16, Published 22, Abstract XRCC2 has been shown to increase the some cancers. Here,...
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. SAMM50 encodes Sam50, a mitochondrial outer membrane protein involved in the removal of reactive oxygen species, morphology and regulation mitophagy. Certain single nucleotide polymorphisms have been reported to be correlated with NAFLD. However, contribution occurrence severity Chinese Han cohort has rarely reported. Here, we investigated association between (rs738491 rs2073082) NAFLD cohort, as well...
Poly (ADP-ribose) polymerase 1 (PARP1) has an important role in homologous recombination repair. The purpose of this study was to investigate the effect PARP1 inhibitor on oxaliplatin treatment for colorectal cancer (CRC).A cell counting kit-8 assay used determine sensitivity CRC cells olaparib and/or oxaliplatin. gene and protein expressions gamma histone variant H2AX (γH2AX) were measured by real-time quantitative chain reaction western blotting, respectively. γH2AX foci formation...
Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness metastasis in several malignancies. However, the role of KIF20A colorectal cancer (CRC) is still unclear. This study aimed at investigating potential roles development CRC. The results bioinformatics analysis, immunohistochemical staining, Western blot analysis showed that was overexpressed CRC tissues compared adjacent normal tissues. High expression depth invasion,...
Radiotherapy for rectal cancer has received increasing research attention in recent years; however, no bibliometric assessment been conducted on the progress of this field. This study aimed to visualize evolution and emerging hotspots field radiotherapy using methods. Data were collected from Web Science Core Collection database, including countries, institutions, authors, keywords, co-citations references, CiteSpace software was used analysis. A total 5,372 publications cancer, published...
Abstract Objective This study aimed to conduct a bibliometric analysis of research articles on the relationship between inflammatory bowel disease (IBD) and colorectal cancer (CRC) using CiteSpace summarize current status, hotspots, trends in this field present results visually. Method Research IBD CRC published from 2000 2023 English were selected Web Science Core Collection (Woscc) database. The downloaded as “full record references”. was used cooperative, cluster, co-citation, burst...
The aim of this study was to detect forkhead box L1 (FOXL1) expression in gastric cancer (GC) and analyze its association with the prognosis GC patients. Immunohistochemical staining, Western blotting, quantitative reverse transcriptase polymerase chain reaction were performed FOXL1 tissue 109 Clinicopathological characteristics survival data retrospectively analyzed discover clinical importance expression. chi-square test used relationship between clinicopathological characteristics....
Single nucleotide polymorphisms (SNPs) are associated with the development of certain types cancer. The present study aimed to investigate association between X‑ray repair complementing defective in Chinese hamster cells 2 (XRCC2) SNPs and colorectal cancer (CRC) cell sensitivity poly(ADP‑ribose) polymerase (PARP) 1 inhibitor olaparib (AZD2281). SNaPshot® analysis XRCC2 was performed five CRC lines. AZD2281‑sensitivities were also analyzed using MTT assays. effect AZD2281 on PARP1 expression...
Objective To study the application status and feasibility of natural orifice specimen extraction surgery (NOSES) in colorectal neoplasms by collecting NOSES cases 79 hospitals around China. Methods A total 718 were collected. The data patients included demographic data, surgical postoperative pathology follow-up data. Results The average age was 59.4±10.8 years, BMI is 22.9±6.3 kg/m2, 72.3% received rectal NOSES, 3.5% neoadjuvant therapy. Pathological results showed that stage...
The survival rate of stomach adenocarcinoma patients with immune and stromal scores different clinicopathological features obtained from the TCGA datasets was systematically compared. A list genes that are correlated microenvironment were extracted using database to predict prognosis survival. In addition, differentially expressed by comparing groups. protein-protein interaction network, functional pathway enrichment analyses performed. total 8 hub selected overall disease-free rates. GPNMB...
The treatment of Colorectal cancer (CRC) is extremely complex and survival rates vary depending on the stage disease at time diagnosis. Neoadjuvant chemoradiotherapy (NACRT), conventional for locally advanced rectal (LARC); however, resistance to in LARC difficult predict.In this study, clinical data 126 patients were collected analyzed, relevant validation was performed using GEO database vitro vivo experiments, including Western blotting Real-time quantitative PCR, immunohistochemistry,...
BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula, but few studies have focused on this problem. The purpose the present study was to investigate prevalence and risk factors for intra-abdominal in patients with external fistula. MATERIAL AND METHODS From January 2014 December 2016, medical records 97 fistula were retrospectively reviewed analyzed. evaluated. RESULTS abdominal 31.9% (95%CI: 22.5-41.4%). A total 31 had bleeding. Results revealed that acute kidney...
Objective: To investigate the effects and mechanism of Calcyclin-binding protein (CacyBP) on proliferation invasion non-small cell lung cancer (NSCLC) cells. Methods: Six tissues paired normal were collected from NSCLC patients who underwent surgical treatment in Jinan Central Hospital during 2016. The expression CacyBP these was examined by western blot. mRNA human bronchial epithelial cells (16HBE), lines including A549, H1299, H460 H1975 blot reverse transcription-polymerase chain...
Background. The increasing incidence and mortality of colorectal cancer (CRC) urgently requires updated biomarkers. ABC transporter family is a widespread membrane-bound proteins involved in the transportation substrates associated with ATP hydrolysis, including metabolites, amino acids, peptides proteins, sterols lipids, organic inorganic ions, sugars, metals, drugs. They play an important role maintenance homeostasis body. Purpose. This study aims to search for new markers gene diagnostic...
Background: Human chromosome 12 contains I kappa B kinase interacting protein (IKBIP) is also commonly known as IKIP. The involvement of IKBIP in the growth tumors has only been discussed a small number publications. Purpose: To explore role that plays development wide variety neoplasms, well tumor immunological microenvironment. Methods: UALCAN, HPA, Genotype Tissue Expression, Cancer Genome Maps, and other datasets were used to analyze expression. We thoroughly investigated predictive...
Abstract Background: Previous studies have shown that ASF1B, a H3-H4 histone chaperone, plays key role in cancer. However, the prognostic relevance and mechanism of ASF1B patients with gastric cancer (GC) are not clear. Therefore, we explored its biological function. Methods : From bioinformatics perspective, R software was used for correlation analysis, Gene Set Enrichment Analysis (GSEA) Weighted Coexpression Network (WGCNA) were to screen related differential genes, Oncology（GO）functional...