A5070391136- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Probiotics and Fermented Foods
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Advanced Nanomaterials in Catalysis
- Microbial Metabolism and Applications
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Hydraulic Fracturing and Reservoir Analysis
- Infrared Thermography in Medicine
- Nanoplatforms for cancer theranostics
- Medicinal Plant Pharmacodynamics Research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Lipid metabolism and disorders
- Bacteriophages and microbial interactions
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Terahertz technology and applications
Shanghai Ocean University
2023-2024
Zhuhai Institute of Advanced Technology
2024
Beijing Institute of Technology
2024
Hubei Cancer Hospital
2015-2024
Huazhong University of Science and Technology
2019-2023
Weatherford College
2019
Cancer Clinic
2016
The efficacy of laparoscopic vs open surgery for patients with low rectal cancer has not been established.
Tumor drug resistance caused by the tumor microenvironment is an extremely difficult problem for researchers to solve. Nanoplatforms that integrate diagnosis and treatment have great advantages in treatment, but design synthesis of simple efficient nanoplatforms still face tremendous challenges. In this study, a novel Mn/Au@ir820/GA-CD133 nanoprobe was developed. The manganese dioxide/gold particles were prepared coprecipitation/assembly, chemically coupled with CD133 antibody, finally...
Objective To study the application status and feasibility of natural orifice specimen extraction surgery (NOSES) in colorectal neoplasms by collecting NOSES cases 79 hospitals around China. Methods A total 718 were collected. The data patients included demographic data, surgical postoperative pathology follow-up data. Results The average age was 59.4±10.8 years, BMI is 22.9±6.3 kg/m2, 72.3% received rectal NOSES, 3.5% neoadjuvant therapy. Pathological results showed that stage...
330 Background: Gastrointestinal (GI) cancers totally account for more than one third of the cancerous deaths, yet there is no cost-effective blood-based assay early detection GI cancers. We sought to develop GutSeer, a noninvasive test based on cell-free DNA (cfDNA) methylation and fragmentation signatures derived from single targeted sequencing panel, localization five major cancers, including colorectal (CC), gastric (GC), liver (LC), esophageal (EC), pancreatic cancer (PC). Methods: A...
As one of the most serious cancers, gastric cancer (GC) represents third leading cause malignancy-related deaths. G9a is a histone lysine methyltransferase and has been reported to be involved in progression some human cancers. In present study, we aimed explore expression patterns clinical value GC patients.The 142 paired tissues adjacent non-cancerous (no less than 5 cm from tumor edge) was examined with quantitative real-time polymerase chain reaction (qRT-PCR). To estimate association...
3591 Background: We have previously reported that fruquintinib plus mFOLFOX6/FOLFIRI as the first-line therapy followed by capecitabine maintenance (FRU regimens) for advanced mCRC patients (pts) showed durable response and a favorable safety profile in this prospective, open-label, multicenter, single-arm phase 2 study (NCT05004441). retrospectively collected matching data of standard (STD regimens: bevacizumab/cetuximab chemotherapy) treatment to compare with longer follow-up study....
e21040 Background: Altered lipid metabolism exhibited by cancer cells, this study was conducted to explore the prognostic values of metabolism-related genes and serum lipids for survival in non-small-cell lung (NSCLC) patients. Methods: Differential expression CD36, LDLR, ACLY, ACSS2, FASN, SCD, HMGCR, SQLE tissues were tumor immune estimation resource (TIMER) analysis. The gene profiling interactive analysis (GEPIA) tool used confirm differential levels adenocarcinoma (LUAD) squamous cell...
Objective Collect clinical specimens of gastric cancer patients with metastasis and without metastasis, application molecular biology method confirm cytochrome B in its role the development stomach, provide experimental basis for exploring mechanism cancer. Methods Collect 12 cases confirmed by pathology surgery tissue, including lymph node each six cases. Detect expression two groups tissue apoptosis related factors cell lymphoma/leukemia- 2 associated X protein(bax), 2(bcl- 2),...
Short-term peritoneal recurrence of colon cancer is one the reasons leading to failure treatment.It an effective way reduce by standardize surgical operation and improve quality operation. Cytoreductive surgery hyperthermic intraperitoneal peroperative chemotherapy for metastasis safe effective. Key words: Colorectal neoplasms; Neoplasm metastasis; Cytoreductive surgery; Hyperthermic
Objective To illustrate the anticancer property induced by resveratrol (RSV), extracted from Chinese Medicine Polygonum cuspidatum, and provide theoretical basis for clinical use. Methods Human colorectal adenocarcinoma cell HCT-15 was treated with different concentrations of resveratrol, cells were then observed under light microscope to analyze morphological change. Cell counting kit-8 (CCK-8) assay used detect inhibition ratio proliferation. Immunoblotting changes apopatosis...
Objective The aim of study is to investigate the expression hBmal1 gene in human colon carcinoma tissue and their relation invasion metabasis carcinoma. Methods Immunochemical staining was performed detect protein 30 cases tissues normal from Cancer Hospital Hubei Province. Results The positive rate adjacent noncancerous were 76.67% (23/30) vs 26.67% (8/30) (χ2=15.016, P<0.01). The strong B C Dukes stage 46.15% (6/13) 88.24% (15/17) (χ2=6.212,...
4169 Background: Five major gastrointestinal (GI) cancers - colorectal (CRC), gastric (GC), liver (LC), esophageal (EC), and pancreatic cancer (PC) are responsible for hundreds of thousands mortalities annually worldwide. Unfortunately, there is a lack cost-effective, blood-based screening method their early detection. To address this issue, we aimed to develop GutSeer, noninvasive, targeted methylation sequencing-based test by leveraging fragmentomic signatures carried cell-free DNA...
Objective To study the clinicopathological significance and malignant behavior of human colorectal cancer (CRC) with expression neuronal pentraxin 2 (NPTX2). Methods NPTX2 in 101 CRC paired adjacent normal tissues its were detected by immunohistochemistry (IHC). Real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) Western blotting used to examine NPTX2 protein mRNA levels 18 adjuvant tissues. Finally, small interfering RNA (siRNA) was detect effect...