A5101934783- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Antibiotic Use and Resistance
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Plant Pathogens and Fungal Diseases
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Global Maternal and Child Health
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
- Sugarcane Cultivation and Processing
- FOXO transcription factor regulation
Guangxi University
2004-2025
Guangxi University of Chinese Medicine
2009-2025
Xinxiang Medical University
2025
Ruikang Affiliated Hospital of Guangxi Medical University
2024
Sun Yat-sen University
2019-2024
Peking University First Hospital
2019-2024
Peking University
2019-2024
Huazhong University of Science and Technology
2019-2024
Tongji Hospital
2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2024
This work aimed to investigate tumor-infiltrating immune cells (TIICs) and immune-associated genes in the tumor microenvironment of osteosarcoma.An algorithm known as ESTIMATE was applied for score assessment, osteosarcoma cases were assigned high low groups.Immuneassociated between these groups compared, an optimal immune-related risk model built by Cox regression analyses.The deconvolution (referred CIBERSORT) assess 22 TIICs their amounts microenvironment.Osteosarcoma with had...
The tumor microenvironment (TME) has important effects on the tumorigenesis and development of osteosarcoma (OS). However, dynamic mechanism regulating TME immune matrix components remains unclear. In this study, we collected quantitative data gene expression 88 OS samples from Cancer Genome Atlas (TCGA) database downloaded relevant clinical cases TARGET database. proportions tumor-infiltrating cells (TICs) numbers were determined by CIBERSORT ESTIMATE calculation methods. Protein-protein...
Abstract Background Antimicrobial resistance has been named as one of the top ten threats to public health in world. Hospital-based antimicrobial stewardship programs (ASPs) can help reduce resistance. The purpose this study was determine perceived barriers development and implementation ASPs tertiary care centers three low- middle-income countries (LMICs). Methods Interviews were conducted with 45 physicians at hospitals Sri Lanka (n = 22), Kenya (12), Tanzania (11). assessed knowledge...
Background: Postmenopausal Osteoporosis (PMOP) is characterized by decreased bone mass and deterioration of microarchitecture, leading to increased fracture risk. Current treatments often have adverse effects, necessitating safer alternatives. Kaempferol, a flavonoid identified as key active component the traditional Chinese medicine Yishen Gushu formula, has shown promise in improving health, but its mechanisms PMOP treatment remain unclear. Objective: The aim this study was investigate...
Male late-onset hypogonadism is an age-related disease, the core mechanism of which dysfunction senescent Leydig cells.Recent studies have shown that elimination cells can restore proper homeostasis to aging tissue.In present study, we found fork head box O (FOXO) transcription factor FOXO4 was specially expressed in human and its translocation nucleus elderly related decreased testosterone synthesis.Using hydrogen peroxide-induced TM3 as vitro model, observed maintains viability suppresses...
Osteoporosis (OP) is an age-related skeletal disease. Kaempferol can regulate bone mesenchymal stem cells (BMSCs) osteogenesis to improve OP, but its mechanism related disulfidptosis, a newly discovered cell death mechanism, remains unclear.
The human positive cofactor 4 (PC4) is initially identified as a transcriptional and has an important role in embryonic development malignant transformation. However, the clinical significance molecular mechanisms of PC4 breast cancer progression are still unknown. We investigated expression 114 cases primary matched normal tissue specimens, studied impact well this altered on growth metastasis both vitro vivo. was significantly upregulated high positively correlated with poor prognosis...
Pokkah Boeng Disease (PBD) is a severe and devastating disease that causes significant damage yield losses in China. The pathogenic fungus Fusarium oxysporum responsible for the rapid onset of top rot symptoms sugarcane. In this study, we selected representative strain, BS2-6, to perform morphological observations colonies determine pathogenicity. We examined effects BS2-6 infestation on ultrastructure sugarcane leaves. Moreover, sequenced whole genome various nitrogen sources chemical...
Objective: To investigate the expression, prognosis, and role of G protein-coupled receptor kinase-interacting protein 1 (GIT1) in patients with hepatocellular carcinoma (HCC) tumor micro environments. Methods: Clinical data 140 cases who underwent complete HCC surgical resection from January 2015 to December 2021 Subei People's Hospital affiliated Yangzhou University, Jiangsu Province, were included. Tumor tissue adjacent samples collected for immunohistochemical analysis. The divided into...
Male ageing is always accompanied by decreased fertility. The forkhead O (FOXO) transcription factor FOXO4 reported to be highly expressed in senescent cells. Upon activation, it binds p53 the nucleus, preventing cell apoptosis and maintaining cells situ. Leydig play key roles assisting spermatogenesis. senescence leads deterioration of microenvironment testes impairs In this study, we observed that FOXO4-DRI, a specific FOXO4- binding blocker, induced cells, reduced secretion certain...
Background The aim of this study is to investigate the expression profile multiple epithelial mesenchymal transition (EMT)-related molecules in intrahepatic cholangiocarcinoma (ICC) and related prognostic significance. Methods Immunohistochemistry was performed determine E-cadherin, Vimentin, Snail, slug β-catenin a tissue microarray consisting tumor tissues 140 ICC patients undergoing curative resection. correlation between these clinicopathological characteristics analyzed, their...
An ideal animal model of azoospermia would be a powerful tool for the evaluation spermatogonial stem cell (SSC) transplantation. Busulfan has been commonly used to develop such model, but 30%–87% mice die when administered an intraperitoneal injection 40 mg kg−1. In present study, hematoxylin and eosin staining, Western blot, immunofluorescence, quantitative real-time polymerase chain reaction were test effects busulfan exposure in mouse that received two injections at 3-h interval different...
Chronic hepatitis B is the main cause of liver cancer. However, most neglected group has been treatment-naive chronic patients with normal alanine aminotransferase (ALT). People have tended to subjectively assume that lesions these are not serious and do need antiviral treatment. truth as optimistic we thought. We aimed in this study analyze proportion significant inflammation or fibrosis aforementioned patients.Medline, Embase, Cochrane Library were searched up January 10th 2020, identify...
The proportion of chronic hepatitis B (CHB) patients with normal or mildly elevated alanine transaminase (NMALT) levels who have moderate to severe inflammation was not rare. However, we lacked appropriate biomarkers evaluate liver in these populations. We aimed explore the relationship between quantitative core antibody (qAnti-HBc) and hepatic histological inflammation. This multicenter cohort study enrolled participants from 34 Chinese hospitals including 1376 treatment-naive CHB biopsy...
Immune evasion in glioma strongly correlates with clinical outcomes; however, the molecular mechanisms driving maintenance of immunosuppression remain largely unknown. Recently studies demonstrate that Klothos are aberrantly expressed several cancers and potential therapeutic targets cancers. However, their roles still unclear glioma. Here, we show LCTL is highly gliomas its expression regulated by DNA methylation status at promoter. also found to be significantly associated high tumor...
Fertility preservation is a common concern for male cancer survivors of reproductive age. However, except testicular tissue cryopreservation, which not very effective, there no feasible and precise therapy capable protecting spermatogenesis prepubertal boys before or during gonadotoxic treatment. This study aims to investigate the effects inhibiting necroptosis spermatogonial stem cell (SSC) in fertility preservation. Male mice 12 weeks age were used establish gonadotoxicity with two...