A5087803973- Winter Sports Injuries and Performance
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Lymphatic System and Diseases
- Circular RNAs in diseases
- Pain Mechanisms and Treatments
- Systemic Sclerosis and Related Diseases
- Sports Performance and Training
- Radiopharmaceutical Chemistry and Applications
- Sports Analytics and Performance
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Educational Technology and Pedagogy
- Sports Dynamics and Biomechanics
- Video Analysis and Summarization
- Advanced Decision-Making Techniques
- Pharmacological Effects of Medicinal Plants
- Nanoplatforms for cancer theranostics
- Male Breast Health Studies
- Cancer Cells and Metastasis
- Hippo pathway signaling and YAP/TAZ
- Physical Activity and Education Research
- Cancer, Lipids, and Metabolism
Second Affiliated Hospital of Soochow University
2015-2024
Jianghan University
2008-2024
Soochow University
2015-2024
Henan Provincial Chest Hospital
2024
Northern Jiangsu People's Hospital
2024
Shaoxing University
2013-2023
Soochow University
2022
Changzhou University
2008
Shenyang University of Technology
2007
Standard adjuvant chemotherapy for triple-negative breast cancer (TNBC) includes a taxane and an anthracycline. Concomitant capecitabine may be beneficial, but robust data to support this are lacking. The efficacy safety of the addition into TNBC treatment regimen was evaluated.This randomized, open-label, phase III trial conducted in China. Eligible female patients with early after definitive surgery were randomly assigned (1:1) either (3 cycles docetaxel followed by 3 capecitabine,...
Abstract In order to realize the process of player feature extraction and classification from multi-frequency frame-changing football match images more quickly, complete tactical plan that is conducive game, this paper puts forward a method for analyzing judging tactics women’s team based on Convolutional Neural Network (CNN). By extracting players’ performance in recent training competition continuous video frame data, multi-dimensional vector input data sample formed, CNN used analyze...
Nuclear factor-kappa B (NF-κB) signaling is implicated in both cancer development and inflammation processes. However, the roles mechanisms of NF-κB cancer-induced pain (CIP) remain unknown. This study was designed to investigate p65 subunit regulation purinergic receptor (P2X3R) plasticity dorsal root ganglion (DRG) CIP rats. We showed here that tumor cell injection produced mechanical thermal hyperalgesia, an enhanced body weight-bearing difference, which correlated with upregulation P2X3R...
Abstract Background Cancer-induced bone pain (CIBP) is a complex chronic with poorly understood mechanisms. The anterior cingulate cortex (ACC) plays critical role in processing and modulating pain. This study investigates how the GluR2 receptors (calcium impermeable AMPA receptors) ACC glutamatergic neurons regulate CIBP. Methods CIBP models were established by injecting Walker 256 cells into tibia of SD rats. Paw withdrawal threshold (PWT) paw latency (PWL) used as indicators hyperalgesia....
<title>Abstract</title> Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by intestinal inflammation and barrier dysfunction. This study investigated the therapeutic potential of Cirsiliol, natural flavonoid, in DNBS-induced murine colitis model..Mice were randomly divided into control, model, Cirsiliol treatment groups (10 mg/kg 30 mg/kg). Disease activity was assessed through body weight, colon length, index (DAI). Molecular mechanisms evaluated using...
Ligustrazine, the active ingredient present in Umbelliferae plant roots used Chinese medicine, plays a vital role reversing multidrug resistance tumors. This study aims to investigate its anticancer activity and underlying mechanisms human breast cancer cells vitro vivo.Human cell line MDA-MB-231 was incubated with different concentrations of ligustrazine. The viability assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; apoptosis cycle were flow cytometry....
The aim of this study was to evaluate the procedure for and efficacy endoscopic subcutaneous mastectomy gynecomastia. Endoscopic performed on 100 benign, palpable breast enlargements in 58 male patients who were followed-up 15-63 months. surgery conducted with insufflation CO2 subdermally. No cases converted open surgery. unilateral time 70-90 min. mean volume resected tissue 200 ml. All procedures completed successfully, satisfactory clinical effects ideal esthetic results postoperatively....
The resistance of breast cancer to radiotherapy remains a major obstacle successful management. Radiotherapy may result in DNA damage and activate stem cells. lead activation the checkpoint kinase (CHK) signaling pathway, which debromohymenialdisine (DBH) is specific inhibitor. also increases expression phosphorylated CHK1/2 (pCHK1/2) cell line, MCF-7, vitro dose-dependent manner. DBH relatively stable effective inhibitor that significantly reduces pCHK1/2 MCF-7 proliferation. Low-dose...
Background Cancer-induced pain (CIP) is one of the most severe types chronic with which clinical treatment remains challenging and involved mechanisms are largely unknown. Suppressor cytokine signaling 3 (SOCS3) an important intracellular protein provides a classical negative feedback loop, thus involving in wide variety processes including inflammation nociception. However, role SOCS3 pathway CIP poorly understood. The present study was designed to investigate dorsal root ganglion (DRG)...
Triple-negative breast cancer (TNBC) is currently the most malignant subtype of without effective targeted therapies. DNAJB4 (Dnaj heat shock protein family (Hsp40) member B4) a human (Hsp40). The clinical significance in has been reported our previous study. However, biological function TNBC cell apoptosis remains unclear to date.The expression normal cells, four-paired tissues, and adjacent noncancerous tissues was quantified by quantitative real-time polymerase chain reaction (qRT-PCR)...
Cytochrome b561 (CYB561) is a transmembrane protein and participates in ascorbate recycling iron homeostasis. However, its role breast cancer remains unclear.In this study, we explored the expression pattern prognostic value of CYB561 through The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), PrognoScan Kaplan-Meier Plotter confirmed mRNA human cell lines. LinkedOmics, Metascape Profiling Interactive Analysis (GEPIA2) databases were applied to investigate co-expression genes...
Cancer stem cells (CSCs) targeted therapy holds the potential for improving cancer management; identification of stemness-related genes in CSCs is necessary its development.The Genome Atlas (TCGA) and Molecular Taxonomy Breast International Consortium (METABRIC) datasets were used survival analysis. ZSCAN1 correlated was identified by Spearman correlation stem-like (BCSLCs) isolated sorting CD44+CD24- from suspension cultured breast (BC) spheroids. The sphere-forming capacity sphere-...
Objectives This study aimed to analyze the population density of vector ticks and reservoir hosts rodents, investigate relevant pathogen infection in Zhejiang Province, China. Methods In this surveillance study, data were collected with tick picking method on animal body surface drag-flag method, while rodent night trapping method. The samples examined for severe fever thrombocytopenia syndrome virus (SFTSV), blood serum organs from rodents subjected SFTSV, hantavirus, Leptospira , Orientia...
Objective. To study the expression of programmed cell death ligand-1 (PD-L1) and breast cancer susceptibility gene 1 (BRCA1) in triple-negative (TNBC) patients analyze their relationship with clinicopathological characteristics. Methods. 76 TNBC tissues were collected as research object, while 60 adjacent used controls. All underwent surgical treatment, PD-L1 BRCA1 was detected by immunohistochemistry. At same time, between PD-L1, BRCA1, characteristics (including patient age, menopausal...
The purpose of this study was to assess the effectiveness and safety in patients with benign phyllodes after performing local excision following intra-operative breast flap reconstruction. Patients (n = 32) eligible cystosarcoma underwent wide followed by Primary outcome measures included average operative time, length in-hospital stay, postoperative recurrence, complications. Thirty-two who surgical oncoplastic surgery were evaluated using BCCT.core software. A satisfactory symmetrical...