A5016852912- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Health Systems, Economic Evaluations, Quality of Life
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Salivary Gland Tumors Diagnosis and Treatment
- RNA Research and Splicing
- Ear and Head Tumors
- Folate and B Vitamins Research
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- PI3K/AKT/mTOR signaling in cancer
- Surgical site infection prevention
- Orthopedic Infections and Treatments
- Immune cells in cancer
- Genomics and Chromatin Dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
Chongqing University
2025
Xiangya Hospital Central South University
2020-2024
Central South University
2020-2024
Guangxi University
2020
Guangxi University of Chinese Medicine
2020
Weatherford College
2020
National Patient Safety Foundation
2020
Ruikang Affiliated Hospital of Guangxi Medical University
2020
This work aimed to investigate tumor-infiltrating immune cells (TIICs) and immune-associated genes in the tumor microenvironment of osteosarcoma.An algorithm known as ESTIMATE was applied for score assessment, osteosarcoma cases were assigned high low groups.Immuneassociated between these groups compared, an optimal immune-related risk model built by Cox regression analyses.The deconvolution (referred CIBERSORT) assess 22 TIICs their amounts microenvironment.Osteosarcoma with had...
Abstract Purpose The study aims to harness the value of radiomics models combining intratumoral and peritumoral features obtained from pretreatment CT predict treatment response as well survival LA-NPC(locoregionally advanced nasopharyngeal carcinoma) patients receiving multiple types induction chemotherapies, including immunotherapy targeted therapy. Methods 276 LA-NPC (221 in training 55 testing cohort) were retrospectively enrolled. Various statistical analyses feature selection...
Abstract Background Sintilimab combined with IBI305 treatment regimen had potential clinical benefits than sorafenib in the first‐line of patients unresectable hepatic cell carcinoma (HCC). However, whether sintilimab plus has economic China remains unclear. Methods From perspective Chinese payers, we used Markov model to simulate HCC receiving and sorafenib. The transition probability between health states was estimated using parametric survival model, cumulative medical costs utility two...
Abstract Objective The KEYNOTE‐590 trial showed that individuals with advanced esophageal cancer who received Pembrolizumab in combination chemotherapy as a first‐line regimen achieved significant extension of survival. However, this treatment option increases the financial burden on patients and economic benefits remain to be further evaluated. Methods A Markov model was used simulate 10‐year survival from perspective United States (US) Medicare payers. We evaluated economics plus PD‐L1...
The national Comprehensive Cancer Network has suggested pembrolizumab as a second-line therapy for esophageal squamous cell carcinoma (ESCC) patients with programmed death ligand-1 (PD-L1) combined positive score (CPS) ≥ 10. However, despite the increased survival rate associated in these patient population, high cost of may influence its antitumor effect. This study aimed to evaluate cost-effectiveness compared chemotherapy treatments (EC) based on KEYNOTE-181 trial.A Markov model was...
Background: Esophageal cancer has a poor prognosis and currently ranks sixth in global mortality rates. The ORIENT-15 trial showed sintilimab plus chemotherapy significantly improved survival when compared to alone. This study aimed evaluate the cost-effectiveness of sintilimab, programmed death-ligand 1 (PD-L1) inhibitor, treating patients with esophageal Methods: A Markov model 10-year horizon was developed based on perspective Chinese healthcare payers. We conducted analysis for combined...
Single nucleotide polymorphisms (SNPs) have been inconsistently associated with gastric cancer (GC) risk. This meta-analysis aimed to synthesize relevant data on SNPs GC.Databases were searched identify association studies of and GC published through January 2020 from the databases PubMed, Web Science, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Science Technology Periodical Database, Wan fang databases. Network Thakkinstian algorithm used select most...
Spatially resolved transcriptomics was honored as the Method of Year 2020 by Nature Methods. This approach allows biologists to precisely discern mRNA expression at cellular level within structurally preserved tissues. Leveraging artificial intelligence in spatial transcriptomic analysis enhances understanding cellular-level biological interactions and offers novel insights into intricate tissues, such tumor microenvironments. Nevertheless, numerous existing clustering algorithms employing...
Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by rearrangement NUT midline family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis treatment remain unavailable, underscoring need expert consensus. To address this gap, we conducted systematic review to gather comprehensive information on from five databases: PubMed, Web Science, Embase, Cochrane Library, Ovid Medline. This consensus was collaboratively...
Single nucleotide polymorphisms (SNPs) have been inconsistently associated with osteosarcoma (OS) risk. This meta-analysis aimed to synthesize relevant data on SNPs OS.Databases were searched identify association studies of and OS published through January 2020 from the databases PubMed, Web Science, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Science Technology Periodical Database, Wan fang databases. Network Thakkinstian algorithm used select most appropriate...
Single nucleotide polymorphisms (SNPs) have been inconsistently associated with pancreatic cancer (PC) risk. This meta-analysis aimed to synthesize relevant data on SNPs PC.Databases were searched identify association studies of and PC published through January 2020 from the databases PubMed, Web Science, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Science Technology Periodical Database (VIP) Wanfang databases. Network Thakkinstian algorithm used select most...
According to the relevant reports that single nucleotide polymorphisms (SNPs) may contribute change of homocysteine (HCY) levels and increase risk hypertension (HTN). During inconsistent results, this meta-analysis purpose is systematically review synthesized data on HCY SNPs in HTN.The systematic search database, from following database find out association studies HTN publications up until March 2020 databases PubMed, Embase, Web Science, Cochrane Library, China National Knowledge...
Abstract Background: Single nucleotide polymorphisms (SNPs) have been inconsistently associated with atrophic gastritis (AG) risk. This meta-analysis aimed to synthesize relevant data on SNPs AG. Methods: To identify all studies of and AG published, databases had searched through January 2020 from the PubMed, China National Knowledge Infrastructure (CNKI), Web Science, Embase, Chinese Science Technology Periodical Database (VIP), Cochrane Library, Wanfang databases. With help network...