A5100422710- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Cellular Mechanics and Interactions
- Esophageal Cancer Research and Treatment
- Tea Polyphenols and Effects
- Nuclear Physics and Applications
- Synthesis of Organic Compounds
- Heat shock proteins research
- Atomic and Subatomic Physics Research
- Hippo pathway signaling and YAP/TAZ
- Synthesis and Biological Evaluation
- Ultrasound and Hyperthermia Applications
- Advanced Radiotherapy Techniques
- Nonmelanoma Skin Cancer Studies
- Multi-Criteria Decision Making
- Cancer and Skin Lesions
- Chronic Kidney Disease and Diabetes
- Pancreatic and Hepatic Oncology Research
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Analysis
Central South University
2014-2025
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Xiangya Hospital Central South University
2013-2025
Massachusetts General Hospital
2025
Harvard University
2025
Guangzhou University of Chinese Medicine
2024
East China Normal University
2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Nanjing Agricultural University
2023
Background/Objectives: The management of periocular skin malignancies presents a unique challenge. Proton beam therapy, due to its sharp dose fall-off, allows for the delivery tumoricidal tumor while sparing adjacent normal tissues. Methods: Thirteen patients with median age 76.5 years received protons at our institution 66.6 Gy (RBE). Sixty-four percent lesions were basal cell carcinoma, and 22% squamous carcinoma. Eighty-six underwent biopsy only or partial resection. Fifty-seven located...
To develop a nomogram for the prediction of new high-grade patterns invasive non-mucinous adenocarcinoma (INMA) based on radiomics and clinical features to provide accurate individualized treatment patients. We collected patients pathologically diagnosed with INMA at our hospital. The study's endpoint, defined as 'new high-grade', was characterized by presence micropapillary ≥5% or (including solid, micropapillary, complex glandular) ≥20%. Patients were randomly divided into training...
Objective. The purpose of this study was to investigate the feasibility applying handcrafted radiomics (HCR) and deep learning-based (DLR) for accurate preoperative classification glioblastoma (GBM) solitary brain metastasis (BM). Methods. A retrospective analysis magnetic resonance imaging (MRI) data 140 patients (110 in training dataset 30 test dataset) with GBM 128 (98 BM confirmed by surgical pathology performed. regions interest (ROIs) on T1-weighted (T1WI), T2-weighted (T2WI),...
Abstract Colon adenocarcinoma (COAD) is one of the most common malignant tumors with high morbidity and mortality rates worldwide. Due to poor clinical outcomes, it indispensable investigate novel biomarkers for diagnosis prognosis COAD. The aim this study explore key genes as potential COAD utility. Gene expression profiles (GSE44076 GSE44861) gene methylation profile (GSE29490) were analyzed identify aberrantly methylated‐differentially expressed by R language Perl software. Function...
MicroRNA (miR)-145 has been shown to act as a suppressor in numerous cancer types, including non-small-cell lung (NSCLC). Fascin 1 (FSCN1), an actin bundling protein, implicated NSCLC. However, the detailed role of miR-145 well association between and FSCN1 regulation migration invasion NSCLC cells remained elusive. The present study revealed that was downregulated upregulated tissues cell lines. Further investigation showed overexpression markedly inhibited protein expression FSCN1, while...
Survival analysis methods have gained widespread use in the filed of oncology. For achievement reliable results, methodological process and report quality is crucial. This review provides first examination characteristics reporting survival articles published leading Chinese oncology journals.To examine analysis, to identify some common deficiencies, desirable precautions relate advice for authors, readers, editors.A total 242 were included be evaluated from 1492 4 journals 2013. Articles...
Background Single nucleotide polymorphisms (SNPs) in DNA repair genes can alter gene expression and activity affect response to cancer treatment and, correspondingly, survival. The present study was designed evaluate the utility of XRCC1 Arg399Gln ERCC1 Cys8092Ala SNPs, measured pretreatment biopsy samples, as predictors radiotherapy patients with non-metastatic nasopharyngeal carcinoma (NPC). Materials methods included 75 consecutive stage II-IVA-B NPC. Arg399Glu SNPs were identified from...
In recent years, many researches have shown that OCT4 is overexpressed in both germ cell tumors and somatic cancers. Meanwhile, has relationship with poor prognosis a lot of solid tumors, such as hepatocellular carcinoma, gastric cancer, esophageal cancer. our study, we investigated the expression status its clinical significance patients acute myeloid leukemia (AML) using real-time quantitative PCR. The receiver operating characteristic (ROC) curve reveals level could be available for...
The aim of the present study was to quantitatively diagnose and monitor therapy response hepatic ischemia-reperfusion injury (IRI) with use targeted ultrasound (US) imaging. Targeted microbubbles (MBs) were fabricated, binding intracellular adhesion molecule 1 (ICAM-1) antibodies MBs observed. To establish a quantitative method based on US imaging, contrast-enhanced applied for IRI rats. After andrographolide treatment, rats subjected imaging therapeutic effect. Effective ICAM-1 According...
Hyperthermia is a promising treatment for human cervical cancer. However, little known about whether and under what conditions heat exerts tumor inhibition effects on cancer, the molecular mechanisms behind these cellular responses have yet to be elucidated. We employed cancer cell line CaSki as model examined effect of apoptosis proliferation gradient thermal (43, 45 47˚C 40 min). Heat was found induce necrosis. Cell cycle analysis showed that cells were arrested in S phase upon application...
MicroRNA (miR)-133b has been reported to act as a tumor suppressor in multiple types of human cancers, including non small cell lung cancer (NSCLC). However, the underlying mechanism by which miR‑133b inhibits NSCLC metastasis remains largely unclear. In present study, reverse transcription‑quantitative polymerase chain reaction and western blotting were used detect messenger RNA protein expression. A wound healing assay transwell examine migration invasion. The expression level was found be...
Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC line (SW620R) examined the role of YAP chemotherapy resistance. We showed promoted resistance CRC. To increase efficacy treatment, employed another therapeutic target EGFR which interacts with upstream signaling molecules Hippo pathway. Verteporfin, specific inhibitor, inhibits activity by...
Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use different treatments, breast remains a major cause mortality. Therefore, it is imperative to identify promising treatment options. In present study, we investigated effects shikonin on 4T1 cells its potential mechanisms action.
Abstract Objective The KEYNOTE‐590 trial showed that individuals with advanced esophageal cancer who received Pembrolizumab in combination chemotherapy as a first‐line regimen achieved significant extension of survival. However, this treatment option increases the financial burden on patients and economic benefits remain to be further evaluated. Methods A Markov model was used simulate 10‐year survival from perspective United States (US) Medicare payers. We evaluated economics plus PD‐L1...
Abstract Background Codon 72 (Arg/Pro), the most frequently studied single nucleotide polymorphism (SNP) of p53 to date, is associated with ability gene induce cell apoptosis. The PI3K/Akt pathway plays an essential role in transcriptional activation function p53, and important factor radiotherapy resistance. present study was designed evaluate prediction response based on codon SNP pAkt expression biopsy specimens locoregional nasopharyngeal carcinoma (NPC) before treatment. Materials...
Abstract Background: Recent studies have demonstrated that blood-based multi-cancer early detection (MCED) approaches may hold promise for identifying asymptomatic cancer patients from general population. However, most only exploit a single aspect of hallmarks, which is challenging the biological reasons as heterogenous disease with wide spectrum pathological and clinical behaviors. Here we report multi-omics MCED assay named SeekInCare, CE-IVD Mark blood test, incorporates genomic...
The visual system relies on both motion and form signals to perceive the direction of self-motion, yet coordination mechanisms between these two elements in this process remain elusive. In current study, we employed heading perception as a model delve into interaction characteristics signals. We recorded responses neurons ventral intraparietal area (VIP), an with strong selectivity, motion-only, form-only, combined stimuli simulated self-motion. Intriguingly, VIP responded form-only cues...
Background: There are currently limited real-world data on the effectiveness and safety of first-line pembrolizumab combined with chemotherapy in patients advanced/recurrent or metastatic esophageal squamous cell carcinoma (ESCC) China. This study was conducted to address this knowledge gap. Methods: multicenter retrospective cohort at 17 hospitals China included adults (⩾18 years) stage IV primary ESCC, recurring 6 months after radical radiotherapy/surgery-based combination therapy, who had...