A5000528066- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Synthesis of β-Lactam Compounds
- Plant Gene Expression Analysis
- Synthesis and Biological Evaluation
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Plant Stress Responses and Tolerance
- SARS-CoV-2 and COVID-19 Research
- Cancer-related gene regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Immune cells in cancer
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- vaccines and immunoinformatics approaches
- Plant Molecular Biology Research
- Long-Term Effects of COVID-19
- ATP Synthase and ATPases Research
- Genetic factors in colorectal cancer
Inner Mongolia Medical University
2025
Central South University
2018-2024
China Tobacco
2022-2024
Nanjing University of Chinese Medicine
2019-2024
Xiangya Hospital Central South University
2018-2024
Nanjing Agricultural University
2024
Second Xiangya Hospital of Central South University
2024
Yunnan Academy of Forestry
2024
Hunan Cancer Hospital
2021-2023
Guangzhou University of Chinese Medicine
2023
Abstract Background Immune checkpoint blockade (ICB) therapy has demonstrated considerable clinical benefit in several malignancies, but shown favorable response only a small proportion of cancer patients. Recent studies have that matrix metalloproteinases (MMPs) are highly associated with the microenvironment tumors and immune cells. However, it is unknown whether MMPs involved immunotherapy. Methods Here, we used integrative analysis to explore expression landscape MMP family its...
Abstract Circular RNAs (circRNAs) play important roles in the regulation of cancer. However, clinical implications and regulatory networks circRNAs cancer patients receiving immune checkpoint blockades (ICB) have not been fully elucidated. Here, we characterize circRNA expression profiles two independent cohorts 157 ICB-treated advanced melanoma reveal overall overexpression ICB non-responders both pre-treatment early during therapy. Then, construct circRNA-miRNA-mRNA to circRNA-related...
Immune checkpoint blockade (ICB) therapies exhibit substantial clinical benefit in different cancers, but relatively low response rates the majority of patients highlight need to understand mutual relationships among immune features. Here, we reveal overall positive correlations checkpoints and cell populations. Clinically, benefiting from ICB exhibited increases for both stimulatory inhibitory features after initiation therapy, suggesting that activation microenvironment might serve as...
Immune checkpoint blockade (ICB) therapy, represented by programmed cell death protein 1 (PD-1) and its ligand (PD-L1) monoclonal antibodies (mAbs), has shown an obvious benefit for melanoma immunotherapy, but the overall response rate is still low. To find effective combination therapy strategy, we successfully produced small size silver nanoparticles coated with sucrose (S-AgNPs) as potent adjuvants. The antitumor effects of S-AgNPs were tested in vitro comparatively investigated...
Increasing evidence from observational studies and clinical experimentation has indicated a link between the gut microbiotas (GMs) polycystic ovary syndrome (PCOS), however, causality direction of microbiome PCOS remains to be established. We conducted comprehensive search four databases-PubMed, Cochrane Library, Web Science, Embase up until June 1, 2023, subjected results meta-analysis. In this study, bidirectional two-sample Mendelian randomization (MR) analysis was employed investigate...
PDGFRB is a type III tyrosine-protein kinase that abnormally expressed in various cancers and can serve as biomarker for cancer prognosis, studies have demonstrated. However, pan-cancer analysis of has not yet been carried out. The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases were utilized to analyze expression levels. Differential standard, tumor, different clinical stage samples was calculated using R software (version 3.6.4). Immunohistochemical staining...
Abstract Colon adenocarcinoma (COAD) is one of the most common malignant tumors with high morbidity and mortality rates worldwide. Due to poor clinical outcomes, it indispensable investigate novel biomarkers for diagnosis prognosis COAD. The aim this study explore key genes as potential COAD utility. Gene expression profiles (GSE44076 GSE44861) gene methylation profile (GSE29490) were analyzed identify aberrantly methylated‐differentially expressed by R language Perl software. Function...
Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases colorectal cancer and rarely expressed primary tumors, which plays an important role the metastasis cells. Metabolism reprogramming a hallmark cells, aerobic glycolysis is metabolic adaption for cells promotes cell proliferation. However, association between PRL-3 not well understood. In present study, we explored glycolysis. We that improved glucose assumption, lactate production reduced...
Ophiopogonin-B (OP-B) has been reported to suppress metastasis and angiogenesis of adenocarcinoma A549 cells in vitro vivo.More more evidences indicate that inflammatory microenvironment facilitates tumor metastasis.Digital Gene Expression (DGE) analysis non-small cell lung cancer (NSCLC) lines showed OP-B downregulated the expression linc00668, which promoted progression cancer.Herein, we simulated by co-culturing with LPS-treated THP-1 found level linc00668 increased significantly mock...
Abstract Melanoma is the most invasive type of skin cancer, in which immune system plays a vital role. In this study, we aimed to establish prognostic prediction nomogram for melanoma patients that incorporates immune-related genes (IRGs). Ninety-seven differentially expressed IRGs between and normal were screened using gene expression omnibus database (GEO). Among these IRGs, two-gene signature consisting CCL8 DEFB1 was found be closely associated with patient prognosis cancer genome atlas...
Abstract Copper is a micronutrient essential for plant growth and development. However, Cu also heavy metal element that has deleterious impacts on plants when excessively accumulated in the environment. To understand molecular mechanism underlying tobacco response to stress, iTRAQ based technology was used identify differentially expressed proteins (DEPs) important metabolic pathways treated with excessive CuSO4. The results showed 180 DEPs were detected between treatment control, among...
Introduction Stanford type A aortic dissection (TAAD) is one of the lethal macrovascular diseases caused by invasion blood into media layer ascending wall. Inflammation, smooth muscle dysfunction, and extracellular matrix (ECM) degradation were regarded as major pathology in affected tissue. However, expression pattern its regulation especially through circular RNAs (circRNAs) an overall characteristic TAAD molecular remain unclear. Methods We employed CIRCexplorer2 to identify circRNAs...
Abstract Alternative polyadenylation (APA) is an important posttranscriptional modification commonly involved in tumor development. However, the functional roles of APA immunity remain largely unknown. Here, we performed in-depth analysis 3′UTR usage protein-coding genes and immune response 10,303 samples across 31 cancer types to develop immune-related event (ImmAPA) score pipeline, integrated algorithm characterize regulatory landscape events immunity–related pathways. Tumor-specific...
Ophiopogonin B (OP-B), a kind of saponin compound that exists in Radix Ophiopogonis is frequently adopted for the treatment lung disease as traditional Chinese medicine.The present work aimed to explore anti-tumor activity OP-B on non-small cell carcinoma (NSCLC) and its possible mechanism.We found OP-B-treated cells suppressed viability proliferation depending concentration, assayed by MTT Alamar Blue (IC50 were 14.22 ± 1.94, 12.14 2.01, 16.11 1.83 μM A549, NCI-H1299, NCI-H460 cells,...
Abstract Humans are exposed to various chemical elements that have been associated with the development and progression of diseases such as coronary artery disease (CAD). However, existing research has primarily focused on relationships between individual CAD without considering overall ionomic profile. Therefore, our aim is employ a multi-element approach investigate patients those comorbid conditions diabetes (CAD-DIA), high blood pressure (CAD-HBP), or lipids (CAD-HBL). Plasma...
Sperm protein antigen 17 (Sp17), expressed in primary as well metastatic lesions >83% of patients with ovarian cancer, is a promising cancer vaccine candidate. Herein we describe the formulation nanoparticle based vaccines on human Sp17 (hSp17) sequence derived peptides, and map immuno-dominant T cell antibody epitopes induced using such formulations. The B region within was found to be same when biocompatible carriers or conventional "mix-in" pro-inflammatory adjuvant CpG, both mapping...
Drought is an important environmental factor affecting plant growth and development. Tobacco a widely cultivated economically crop worldwide. can decrease the yield quality of tobacco. Peroxidase III maintain balance peroxy free radicals H2O2 in plants participate variety physiological processes, including lignin biosynthesis auxin catabolism. In this study, we first found that CRISPR/Cas9-mediated peroxidase 63-like (NtPOD63 L) knockout mutant had high drought tolerance, such as reduced...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that associated with both genetic and environmental factors; however, the underlying pathogenesis of UC remains unclear. The present study aimed to further explore 12 microarray datasets from patients obtained Gene Expression Omnibus repository, for potential through global bioinformatics view, which included identification differentially expressed genes (DEGs), functional enrichments, protein‑protein interactions,...
Abstract Background Kejinyan decoction, as an experienced formula of Zhou Zhongying (the Master Traditional Chinese Medicine) has been widely used in clinic for lung cancer treatment China, while the anti-lung mechanism it is still remained to be elucidated. Herein, our basic study found that survival xenograft mice was significantly prolonged after intragastrically administered high dose decoction (3.8 g per kg BW) 15 days. More importantly, we inhibited metastasis cells vivo. Thus this...