A5021869615- Monetary Policy and Economic Impact
- Financial Markets and Investment Strategies
- Financial Risk and Volatility Modeling
- Market Dynamics and Volatility
- Complex Systems and Time Series Analysis
- Statistical Methods and Inference
- Radiomics and Machine Learning in Medical Imaging
- Pituitary Gland Disorders and Treatments
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Advanced Radiotherapy Techniques
- Spatial and Panel Data Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Enterobacteriaceae and Cronobacter Research
- Cancer-related molecular mechanisms research
- Climate Change Policy and Economics
- Immune cells in cancer
- Oral microbiology and periodontitis research
- Unemployment and Economic Growth
- Fiscal Policy and Economic Growth
- Hematopoietic Stem Cell Transplantation
- Stochastic processes and financial applications
- Cancer, Hypoxia, and Metabolism
Sichuan Academy of Traditional Chinese Medicine
2024-2025
Xiangya Hospital Central South University
2016-2024
Central South University
2016-2024
University of California, Los Angeles
2024
Nankai University
2016-2024
Kunming Medical University
2024
First Affiliated Hospital of Zhengzhou University
2024
Soochow University
2022-2024
First Affiliated Hospital of Soochow University
2022-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Abstract Two‐dimensional gel electrophoresis (2DE) in proteomics is traditionally assumed to contain only one or two proteins each 2DE spot. However, resolution being complemented by the rapid development of high sensitivity mass spectrometers. Here we compared MALDI‐MS, LC‐Q‐TOF MS and LC‐Orbitrap Velos for identification within With Coomassie Blue‐stained spot contained an average at least 42 63 proteins/spot analysis a human glioblastoma proteome pituitary adenoma proteome, respectively,...
Whole genome sequencing (WGS) has been widely used in traceability of food-borne outbreaks nowadays. Here, an interesting connection between Cronobacter sakazakii and acute gastroenteritis (AGE) was noticed. In October 2016, AGE outbreak affecting 156 cases occurred a local senior high school. Case-control study including 70 case-patients 295 controls indicated strong association eating supper at school canteen the onset AGE, as revealed by Odds Ratio (OR: 95.32). Six recovered strains were...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of failure with extremely high mortality few effective treatments. Mesenchymal stem cells (MSCs) may reportedly contribute to tissue repair in ALI ARDS. However, applications MSCs have been restricted due safety considerations limitations terms large-scale production industrial delivery. Alternatively, the MSC secretome has considered promising for use therapeutic approaches advanced pre-clinical clinical...
Abstract Background Periodontitis is a chronic inflammatory condition triggered by immune system malfunction. Mitochondrial extracellular vesicles (MitoEVs) are group of highly heterogeneous (EVs) enriched in mitochondrial fractions. The objective this research was to examine the correlation between MitoEVs and microenvironment periodontitis. Methods Data from MitoCarta 3.0, GeneCards, GEO databases were utilized identify differentially expressed MitoEV-related genes (MERGs) conduct...
Though deep learning has shown successful performance in classifying the label and severity stage of certain disease, most them give few evidence on how to make prediction. Here, we propose exploit interpretability application medical diagnosis. Inspired by Koch’s Postulates, a well-known strategy research identify property pathogen, define pathological descriptor that can be extracted from activated neurons diabetic retinopathy detector. To visualize symptom feature encoded this descriptor,...
Studies have shown that the cholesterol-lowering medicine statins alter gut microbiome, induce chronic metabolic inflammation, and disrupt glycemic homeostasis. In this study, we aimed to investigate whether effects of atorvastatin (Ator) on microbiome inflammation could be causally correlated. Mice at 8-week age were fed with high-fat diet (HFD) or HFD Ator (HFD+Ator) for 16 weeks. 16S rRNA sequencing stool RNA colon tissue employed analyze intestinal alterations induced by Ator. A human...
Reflectance confocal microscopy (RCM) images skin at cellular resolution and has shown utility for the diagnosis of nonmelanoma cancer in vivo. It potential to define lesion margins before surgical therapy.To investigate feasibility RCM defining basal cell carcinoma surgery.The 10 lesions were evaluated using RCM. Biopsies used confirm results. A protocol was constructed margins. delineate preoperative 13 patients. Intraoperative frozen biopsy margins.In seven (70.0%) cases, identified suing...
The present study aimed to detect microRNA expression levels in the tissues and sera of patients with clear cell renal carcinoma (ccRCC). association ccRCC clinical pathology was analyzed, potential microRNAs as serum markers significance their diagnosis, staging, prognosis selection new therapeutic targets for were discussed. Specific selected according associated literature. TaqMan quantitative polymerase chain reaction (qPCR) technology used determine microRNAs. miR‑34a, miR‑224 miR‑21...
The purpose of this study was to investigate the effect Treg/Th1 imbalance in cadmium-induced lung injury and potential protective astilbin against chicken. Cadmium exposure significantly decreased T-AOC GSH-Px levels SOD activity chicken tissues. In contrast, it increased MDA NO levels. These results indicate that cadmium triggers oxidative stress lungs. Histopathological analysis revealed further induced infiltration lymphocytes lungs, indicating causes pulmonary damage. Further expression...
Sepsis following hemorrhagic shock is a common clinical condition, in which innate immune system suffers from severe suppression. B and T lymphocyte attenuator (BTLA) an immune-regulatory coinhibitory receptor expressed not only on adaptive, but also cells. Our previous data showed that BTLA gene deficient mice were protected septic mortality when compared with wild-type control C57BL/6 mice. Here, we extended our study by treating anti-BTLA monoclonal antibody (clone 6A6; reported to have...
CDK4 is crucial for G1-to-S transition of cell cycle. It well established that ubiquitin-mediated degradations CDK inhibitors and cyclins are pivotal the timely unidirectional progression However, how itself modulated by degradation has been elusive. Here we report steady-state level controlled PAQR4, a member progestin adipoQ receptor family, SKP2, an E3 ubiquitin ligase. Knockdown PAQR4 leads to reduction proliferation, accompanied reduced protein CDK4. reduces polyubiquitination interacts...
Nonfunctional pituitary adenoma (NFPA) seriously affects hypothanamus-pituitary-target organ axis system, with a series of molecule alterations in the multiple levels genome, transcriptome, proteome, and post-translational modifications, those molecules mutually interact molecular-network system. Meta analysis coupled IPA pathway-network program was used to comprehensively analyze nine sets documented NFPA omics data, including quantitative transcriptomics data [280 differentially expressed...
Human prolactin (hPRL) plays multiple roles in growth, metabolism, development, reproduction, and immunoregulation, which is an important protein synthesized a pituitary. Two-dimensional gel electrophoresis (2DE) effective method identity of variants for in-depth insight into functions that protein. 2DE, 2DE-based PRL-immunoblot, mass spectrometry, bioinformatics were used to analyze hPRL human normal (control; n = 8) pituitaries five subtypes pituitary adenomas [NF- (n 3)-, FSH+ LH+...