A5013489913- Ferroptosis and cancer prognosis
- Dialysis and Renal Disease Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Parathyroid Disorders and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Sepsis Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Magnolia and Illicium research
- Acute Ischemic Stroke Management
- Chronic Kidney Disease and Diabetes
- Alkaline Phosphatase Research Studies
- Vitamin C and Antioxidants Research
- NF-κB Signaling Pathways
- Dermatological and Skeletal Disorders
- Frailty in Older Adults
- Polar Research and Ecology
- Ubiquitin and proteasome pathways
- Apelin-related biomedical research
- Neurosurgical Procedures and Complications
- Ginger and Zingiberaceae research
- Biomarkers in Disease Mechanisms
Eighth Affiliated Hospital of Sun Yat-sen University
2017-2024
Sun Yat-sen University
2017-2024
Zhongnan Hospital of Wuhan University
2019-2024
Wuhan University
2019-2024
Capital Medical University
2008-2024
Beijing Shijitan Hospital
2023-2024
Capital University
2021
Hubei Cancer Hospital
2020
Beijing Tian Tan Hospital
2012-2015
Beijing Institute of Neurosurgery
2015
Long non-coding RNAs (LncRNAs) act as competing endogenous (ceRNAs) in colon cancer (CC) progression, via binding microRNAs (miRNAs) to regulate the expression of corresponding messenger (mRNAs). This article aims explore detailed molecular mechanism ceRNA CC. Top mad 5000 lncRNAs and top mRNAs were used perform weighted gene co-expression network analysis (WGCNA), key modules selected. We 405 red module 145 purple build original by online databases. The included 50 target lncRNAs, 41...
Vascular calcification (VC) predicts the morbidity and mortality in cardiovascular diseases. smooth muscle cells (VSMCs) osteogenic transdifferentiation is crucial pathological basis for VC. To date, molecular pathogenesis still largely unclear. Notably, C5a-C5aR1 contributes to development of diseases, its closely related physiological bone mineralization which similar VSMCs transdifferentiation. However, role underlying mechanisms VC remain unexplored.
AIM:To investigate the protective effects of magnolol on sepsis-induced inflammation and intestinal dysmotility. METHODS:Sepsis was induced by a single intraperitoneal injection lipopolysaccharide (LPS).Male Wistar rats were randomly assigned to one three treatment groups: prior LPS (LPS/Mag group); vehicle (LPS/Veh saline (Control/Veh).Intestinal transit circular muscle mechanical activity assessed 12 h after injection.Tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), monocyte...
Background A comprehensive understanding of vascular calcification pathology is significant for the development cardiovascular disease therapy in high-risk populations. This cross-sectional study aimed to evaluate prevalence and characteristics radial artery (RAC) identify factors that are associated with RAC end-stage kidney (ESKD).Methods Detailed medical histories 180 patients ESKD were recorded. Fragments obtained during creation arteriovenous fistula hemodialysis access stained alizarin...
Ubiquinol-cytochrome c reductase core protein 2 (UQCRC2) is an important mitochondrial complex III subunit.This study investigated the role of UQCRC2 in gastric cancer (GC) and its upstream regulatory microRNAs (miRNAs).UQCRC2 expression levels were lower GC tissues than non-carcinoma tissues.Furthermore, negatively correlated with lymph node metastasis, relapse, tumor grade.Bioinformatics analysis predicted as target gene for miR-370, this was verified luciferase reporter assays.MiR-370...
Delayed intestinal perforation has various manifestations. For peritonitis with delayed treatment and multi-bacterial peritonitis, we should be alert to the occurrence of this rare complication. Abdominal CT examination imaging results judgment based on clinical conditions are particularly important for diagnosis. peritoneal dialysis catheter is a but serious We reported 49-year-old patient who had been hospitalized twice within 3 months due poor drainage catheter. During first...
This study aimed to determine the frequency and determinant factors of do not resuscitate (DNR) orders in patients with intracerebral hemorrhage (ICH) at a university hospital China.Data collected from June 2010 December 2012 for ICH were retrospectively reviewed. The characteristics care without DNR those early (≤24 h) late (>24 establishment compared.Formal filed during hospitalization 64/759 (8.4%) complete medical records enrolled this study. Patients older on average (73.1 ± 10.1 vs....
Breast cancer is the most prevalent malignancy among females, but molecular mechanisms involved in its pathogenesis and progression have remained to be fully elucidated. The aim of present study was identify novel potential therapeutic targets for breast cancer. dataset GSE76275 downloaded from Gene Expression Omnibus database weighted gene co‑expression network analysis (WGCNA) performed hub genes. Furthermore, GSE25055, containing expression data clinical information, validate survival...
Studies on prognostic factors for older patients with intra-abdominal sepsis are scarce, and the association between skeletal muscle mass prognosis among such remains unclear.To develop a nomogram to predict in-hospital mortality sepsis.Older were prospectively recruited. Their demographics, clinical features, laboratory results, abdominal computed tomography-derived mass, recorded. The predictors of selected via least absolute shrinkage selection operator multivariable logistic regression...
Pneumocystis jirovecii pneumonia is an opportunistic infection that affects HIV-infected and immunocompromised persons rarely immunocompetent patients. However, after the advent of COVID-19 pandemic, some patients without immunocompromise or HIV were infected with P. jirovecii. Clinical manifestations atypical, easily misdiagnosed, rapidly progressive, prognosis was poor.
Objective Treatment of syncope in older adults places a burden on healthcare systems. We used five risk stratification tools to predict short-term adverse outcomes patients with syncope. Methods This was retrospective analysis (age ≥60 years) the emergency department an urban academic hospital. The data were evaluated using Risk Stratification Syncope Emergency Department (ROSE), San Francisco Rule (SFSR), FAINT, Canadian Score (CSRS), and Boston Criteria (BSC) tools. Sensitivity,...
Key Points In patients with acute decompensated heart failure and AKI, higher urinary cytokeratin 20 (CK20) associated risk of AKI-to-CKD progression. Urinary CK20, particularly combined clinical variables, improved the ability predicting AKI-CKD transition an accuracy 90%. CK20 might be used as a novel tool for early identifying at high kidney function loss after AKI. Background Predicting remains major challenge in management (ADHF) This study investigated utility (CK20), biomarker...
Background: Autogenous arteriovenous fistula (AVF) is the best vascular hemodialysis access for terminal chronic renal failure patients but prone to thrombosis. Pathogenic mechanisms of AVF thrombus are thus largely explored. As exosomes carry genetic content from cell origin. We hypothesized that miRNAs in serum promising regulators Methods: Serum were isolated maintenance (MHD) patient, profile was obtained by high throughput sequencing, six (miR-144-5p, miR-18a-5p, miR-200a-3p,...
Objective This passage aims at providing the evidence and reference for reducing incidence of postoperative pancreatic fistula its mortality, via analyzing domestic exotic passages which research risk factor after pancreaticoduodenectomy. Methods The references published between 1995 2019, are related to pancreaticoduodenectomy were collected by searching national international databases. Then a meta-analysis is carried out Revman 5.3. Results The (POPF) higher in whom has high...