A5062747558- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Enhanced Recovery After Surgery
- RNA modifications and cancer
- MicroRNA in disease regulation
- Stoma care and complications
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Liver physiology and pathology
- Circular RNAs in diseases
- Bioactive natural compounds
- Cancer Mechanisms and Therapy
- Soft tissue tumor case studies
- Ginger and Zingiberaceae research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Occupational and environmental lung diseases
- Mesenchymal stem cell research
- Neuroscience of respiration and sleep
- Traditional Chinese Medicine Analysis
- Neuroendocrine regulation and behavior
- IgG4-Related and Inflammatory Diseases
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
Wuhan University
2019-2024
Zhongnan Hospital of Wuhan University
2019-2024
Hubei Cancer Hospital
2022-2023
Pingdingshan University
2020
Daping Hospital
2019
Army Medical University
2014-2019
Dalian Medical University
2016-2017
Chongqing Medical University
2015-2017
Second Affiliated Hospital of Chongqing Medical University
2016-2017
Abstract Background Malignant peritoneal mesothelioma (MPM) is an extremely rare and highly invasive tumor. Due to the lack of accurate models that reflect biological characteristics primary tumors, studying MPM remains challenging associated with exceedingly unfavorable prognosis. This study was aimed establish a new potential preclinical model for using patient-derived organoids (MPMOs) comprehensively evaluate practicality this in medical research its feasibility guiding individualized...
Inflammation and oxidative stress serve an important role in the development of lipopolysaccharide/D-galactosamine (LPS/GalN)‑induced acute liver injury. Nobiletin, which is found high quantities peel citrus fruits, able to modulate immune responses, including inflammatory response stress. The present study aimed evaluate protective effects nobiletin on LPS/GalN‑induced Male C57BL/6 mice were intraperitoneally treated with (50, 100 200 mg/kg) 2 h prior LPS/GalN injection. Liver injury was...
Long non-coding RNAs (LncRNAs) act as competing endogenous (ceRNAs) in colon cancer (CC) progression, via binding microRNAs (miRNAs) to regulate the expression of corresponding messenger (mRNAs). This article aims explore detailed molecular mechanism ceRNA CC. Top mad 5000 lncRNAs and top mRNAs were used perform weighted gene co-expression network analysis (WGCNA), key modules selected. We 405 red module 145 purple build original by online databases. The included 50 target lncRNAs, 41...
Acute lung injury (ALI) is characterized by overwhelming inflammation and anti-inflammation treatment proposed to be a therapeutic strategy for ALI. Agmatine, cationic polyamine formed decarboxylation of L-arginine, an endogenous neuromodulator that plays protective roles in diverse central nervous system (CNS) disorders. Consistent with its neuromodulatory neuroprotective properties, agmatine has been reported have beneficial effects on depression, anxiety, hypoxic ischemia, Parkinson’s...
Although chemotherapy is one of the effective means treating gastric cancer, resistance chemotherapeutic drugs has followed. And mechanisms are not completely clear. The main aim this article was to develop a kind drug that could reduce cisplatin on cancer cells.The MGC-803 and MGC-803/DDP cells were treated by for 48 h Lidocaine (Lido) 24 h. Cell viability, apoptosis, migration invasion tested cell counting kit-8 (CCK-8) assay, apoptosis western blot, assay. After transfected h, expression...
Abstract CircRNAs play an important role in the progression of hepatocellular carcinoma (HCC), however, circ_0007429 HCC remains unknown. Using bioinformatics tools, we selected that was most highly expressed tissues and investigated its progression. Immunohistochemistry, plasmid transfection, real‐time quantitative PCR, western blot analysis were used to identify relationship between potential target, miR‐637, TRIM71. The regulatory effect on miR‐637/TRIM71/Ago2 signaling key studied vitro....
Liver fibrosis is a global health problem and its relationship with imidazoline I2 receptor has not been reported. This study aimed to investigate the effects underlying mechanisms of (I2R) inhibitor idazoxan (IDA) on carbon tetrachloride (CCl4)-induced liver fibrosis. In vivo in mice was induced by intraperitoneally injections CCl4 for eight weeks, vitro studies were performed activated LX2 cells treated transforming growth factor-β (TGF-β). Our results showed that IDA significantly...
Objectives: The knowledge that agmatine is found in the human body has existed for several years; however, its role sepsis not yet been studied. In present study, we investigate of progression and treatment sepsis. Design: Clinical/laboratory investigations. Setting: Medical centers/University-based research laboratory. Subjects: Elective ICU patients with severe healthy volunteers; C57BL/6 mice weighing 18–22 g. Interventions: Serum level associations inflammatory markers were assessed...
Breast cancer is the most prevalent malignancy among females, but molecular mechanisms involved in its pathogenesis and progression have remained to be fully elucidated. The aim of present study was identify novel potential therapeutic targets for breast cancer. dataset GSE76275 downloaded from Gene Expression Omnibus database weighted gene co‑expression network analysis (WGCNA) performed hub genes. Furthermore, GSE25055, containing expression data clinical information, validate survival...
Abstract Background : Solitary fibrous tumors (SFTs) originating from the pancreas are rare, only 23 cases have been reported so far. Here, we report largest one, which has its unique treatment characteristics. Case A 42-year-old woman was admitted to hospital with abdominal pain and mass, preoperative diagnosis unclear. As mass rich in blood vessels, she underwent partial pancreatectomy after embolizing part of vessels by intervention, which, at final pathology, showed spindle oval cell...