A5016310970- 3D Printing in Biomedical Research
- Hydrogen's biological and therapeutic effects
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Inhalation and Respiratory Drug Delivery
- Hippo pathway signaling and YAP/TAZ
- Biochemical effects in animals
- Cancer, Hypoxia, and Metabolism
- Cardiac Health and Mental Health
- Medicinal Plant Pharmacodynamics Research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Cancer Mechanisms and Therapy
- Asthma and respiratory diseases
- Gynecological conditions and treatments
- Cardiovascular Health and Risk Factors
Hunan Normal University
2018-2024
Hunan Provincial People's Hospital
2018-2024
Clinical Trial Investigators
2024
Beijing University of Technology
2020-2022
Ningxia Medical University
2021
Sichuan Fire Research Institute
2021
Nanjing Medical University
2020
Kunming Medical University
2018-2020
First Affiliated Hospital of Kunming Medical University
2018-2020
Tsinghua University
2011-2015
Resveratrol (RES) protects myocardial cells from hypoxia/reoxygenation (H/R)-caused injury. However, the mechanism of this effect has not been clarified. Thus, in study, we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting tumor necrosis factor-alpha (TNF-α)/receptor-interacting protein kinase 1 (RIP1)/RIP3/mixed-lineage domain-like (MLKL) signaling pathway. Rat ischemia/reperfusion (I/R) models and H/R-injured were constructed. Our study showed that H/R...
Ginsenoside-Rg1 (G-Rg1), a saponin that is primary component of ginseng, effective against inflammatory diseases. The P2X purinoceptor 7 (P2X7) receptor an ATP-gated ion channel predominantly expressed in immune cells and plays key role processes. We investigated the G-Rg1 sepsis-related cardiac dysfunction underlying mechanism involving regulation P2X7 receptor. detected cell viability, cytotoxicity, cellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) with...
Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), can reduce cardiovascular events and mortality in patients with heart failure. A number mechanisms have been proposed to explain the beneficial effects SGLT2 inhibitors. The purpose this study was determine whether dapagliflozin improve pulmonary vascular remodelling efficacy as an add-on therapy sildenafil rats arterial hypertension (PAH).A monocrotaline (MCT)-induced PAH rat model used our study. MCT-injected...
Abstract The potential for preventive and therapeutic applications of H 2 have now been confirmed in various disease. However, the effects on health status not fully elucidated. Our previous study reported changes body weight 13 serum biochemical parameters during six-month hydrogen intervention. To obtain a more comprehensive understanding long-term consumption, plasma metabolome gut microbiota were investigated this study. Compared with control group, 14 10 differential metabolites (DMs)...
Left atrial appendage closure (LAAC) is an alternative to oral anticoagulation for stroke prevention in non-valvular fibrillation (AF). Selecting the appropriate size of Watchman device very important intra-procedure. There are several methods have been reported measure left (LAA), but each them has its limitations. We investigated efficacy and safety using novel "steel ball method" compared traditional "sheath TEE during procedure LAAC with AF patients. Patients who underwent at The First...
The current study examined the influence of culture substrates modified with functional groups –OH, –COOH, –NH 2 , and –CH 3 using SAMs technology, in conjunction TAAB control, on osteogenic differentiation rabbit BMSCs. CCK-8 assay revealed that BMSCs exhibited substrate-dependent cell viability. cells plated - –OH-modified were well spread homogeneous, but those –COOH- -modified showed more rounded phenotype. mRNA expression substrate promoted contribution ERK1/2 signaling pathway to...
Abstract Molecular hydrogen (H 2 ) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support functions attributed the biological activities of H remain elusive. Here, using transcriptomic metabolomic approaches coupled with biochemistry micro-CT technics, we evaluated effect long-term (6 months) daily use on liver function. Rats exposed h either drinking HRW dissolved O) or breathing 4% gas showed reduced...
This study investigated how human adipose stem cells (hASCs) could be influenced by surface chemistry. Self-assembled monolayers of alkanethiolates on gold were introduced as a chemistry model to provide range functional groups such OH, COOH, NH₂, Phenyl, SH, Br, and CH₃ surfaces. Initially, morphological changes hASCs in response different chemistries observed with focal adhesion. Cell growth behaviour evaluated Counting Kit-8 (CCK8) assay (Dojindo Molecular Technologies Inc., Shanghai,...
Acute lung injury (ALI) is characterized by overwhelming inflammation and anti-inflammation treatment proposed to be a therapeutic strategy for ALI. Agmatine, cationic polyamine formed decarboxylation of L-arginine, an endogenous neuromodulator that plays protective roles in diverse central nervous system (CNS) disorders. Consistent with its neuromodulatory neuroprotective properties, agmatine has been reported have beneficial effects on depression, anxiety, hypoxic ischemia, Parkinson’s...
Abstract Background: Prostaglandin-E1 (PGE1) is a potent vasodilator with anti-inflammatory and antiplatelet effects. However, the mechanism by which PGE1 contributes to amelioration of cardiac injury remains unclear. Methods: The present study was designed investigate how protects against hypoxia/reoxygenation (H/R)-induced injuries regulating microRNA-21-5p (miR-21-5p) fas ligand (FASLG). Rat H9C2 cells isolated primary cardiomyocytes were cultured under hypoxic conditions for 6 h (6H,...
Abstract The potential therapeutic effects of molecular hydrogen (H 2 ) have now been confirmed in various human and animal-disease models. However, the H on physiological function a normal state largely neglected. Hydrogen-rich water (HRW) intake inhalation (HI) are most common used methods for administration, difference between HRW HI remains elusive. In present study, body weight 13 serum biochemical parameters were monitored during six-month intervention, all these significantly altered...
Periodontitis is a chronic inflammatory disease that occurs in periodontal tissues and can cause tooth loosening loss severe cases. As the main effector of downstream Hippo signaling pathway, yes-related protein 1 (YAP1) plays an important role cell proliferation differentiation. However, YAP1 periodontitis has not been reported.Cell activity was detected by Cell Counting Kit-8 (CCK-8). overexpressed transfection, then RT-qPCR western blot were used to detect expression YAP1. The determined...
microRNAs (miRs) are essential in the development of heart failure. The aim this study is to investigate effect microRNA-330 (miR-330) on left ventricular remodeling via TGF-β1/Smad3 signaling pathway by targeting sex-determining region Y (SRY) mice with myocardial ischemia-reperfusion injury (MIRI). Differentially expressed gene (DEG) (IR) was screened out and miR that targeted DEG also predicted verified. A model MIRI established detect expression miR-330, SRY, transforming growth factor-β...
MED19 is a member of the Mediator that plays key role in activation and repression signal transduction or regulation transcription carcinomas. To tested functional human prostate cancer, we downregulated expression cancer cells (PC-3 DU145) by lentivirus-mediated short hairpin (shRNA), analyzed effect inhibition on cell proliferation tumorigenesis. The vitro proliferation, colony formation, vivo tumor growth nude mice xenografts was significantly reduced after downregulation MED19. Knockdown...
Background. Pulmonary arterial hypertension (PAH) usually causes right ventricular dysfunction, which is closely related to cardiac fibrosis. But fibrosis mechanism remains unclear. Our purpose was explore microRNA-325-3p (miR-325-3p)/human epididymis protein 4’s (HE4) role in the occurrence and development of PAH. Methods. The model rats with PAH constructed, miR-325-3p overexpressed miR-325-3p’s effect on myocardial Pearson correlation coefficient examined between HE4 miR-325-3p. We...
The levels of human epididymis protein 4 (HE4) is associated not only with the prognosis patients acute heart failure (AHF), but also chronic kidney disease (CKD). Our study aims to understand prediction value HE4 on in AHF combined CKD.
Importance The optimal strategy of combining left atrial appendage occlusion (LAAO) with catheter ablation (CA) in patients fibrillation (AF) during a single procedure remains unclear. Objective To determine the effects ablation-first vs occlusion-first strategies on long-term clinical outcomes among undergoing combined LAAO and CA procedure. Design, Setting, Participants prospective, multicenter COMBINATION randomized trial was conducted 14 high-volume centers China. Enrollment nonvalvular...
The interactions between cancer cells and the extracellular matrix (ECM) are important with respect to a number of cell behavoirs, yet remain unclear. In this study, self-assembled monolayers different terminal chemical groups (hydroxyl (-OH), carboxyl (-COOH), animo (-NH2), mercapto (-SH), methyl (-CH3)) were employed as substrates for culture MCF-7 examine effects on behavior. Cell spreading was investigated by scanning electron microscopy, tallin expression immunofluorescence,...