A5020785991- Pulmonary Hypertension Research and Treatments
- Geotechnical Engineering and Underground Structures
- Numerical methods in engineering
- Probabilistic and Robust Engineering Design
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Bat Biology and Ecology Studies
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Vascular Anomalies and Treatments
- Peptidase Inhibition and Analysis
- Fatigue and fracture mechanics
- Dam Engineering and Safety
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Structural Response to Dynamic Loads
- Exercise and Physiological Responses
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Food Allergy and Anaphylaxis Research
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 detection and testing
- Network Traffic and Congestion Control
- Cancer Mechanisms and Therapy
- Gout, Hyperuricemia, Uric Acid
- Regulation of Appetite and Obesity
Shanghai Jiao Tong University
2021-2024
Tongren Hospital
2023
Second Xiangya Hospital of Central South University
2018-2023
Central South University
2018-2023
Beijing Institute of Technology
2022-2023
Northwest University
2022
Shantou University
2017
East China Normal University
2012-2014
University of California, Los Angeles
1998-2000
Northwestern Polytechnical University
1993
Spatial transcriptomics (ST) provides insights into the tumor microenvironment (TME), which is closely associated with cancer prognosis, but ST has limited clinical availability. In this study, we provide a powerful deep learning system to augment TME information based on histological images for patients without data, thereby empowering precise prognosis. The two connections bridge existing gaps. first integrated graph and image (IGI-DL) model, predicts expression 0.171 increase in mean...
Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), can reduce cardiovascular events and mortality in patients with heart failure. A number mechanisms have been proposed to explain the beneficial effects SGLT2 inhibitors. The purpose this study was determine whether dapagliflozin improve pulmonary vascular remodelling efficacy as an add-on therapy sildenafil rats arterial hypertension (PAH).A monocrotaline (MCT)-induced PAH rat model used our study. MCT-injected...
Research during the past decades has yielded numerous insights into presence and function of lactate in body. Lactate is primarily produced via glycolysis plays special roles regulation tissues organs, particularly cardiovascular system. In addition to being a net consumer lactate, heart also organ body with greatest consumption. Furthermore, maintains homeostasis through energy supply signal under physiological conditions. affects occurrence, development, prognosis various diseases. We will...
We investigated the reactions of four bat species from different lineages to UV light: Hipposideros armiger (Hodgson, 1835) and Scotophilus kuhlii Leach, 1821, which use constant frequency (CF) or modulation (FM) echolocation, respectively; Rousettus leschenaultii (Desmarest, 1820) Cynopterus sphinx (Vahl, 1797), cave tree-roosting Old World fruit bats, respectively. Following acclimation training involving aversive stimuli when exposed light, individuals S. C. such displayed conditioned...
Lung cancer is the tumor with highest morbidity and mortality, has become a global public health problem. The incidence of lung in men declined some countries regions, while women been slowly increasing. Therefore, aim to explore whether estrogen-related genes are associated prognosis cancer.We obtained all estrogen receptor signaling pathway Cancer Genome Atlas (TCGA), then compared expression each gene tissues adjacent normal for adenocarcinoma (LUAD) squamous cell carcinoma (LUSC)...
There is an increased concern that statins may have unintended effect of elevated lipoprotein(a) [Lp(a)]. We conducted a large sample real-world study to test the association.This retrospective cohort was using data from integrated SuValue database, which includes 221 hospitals across China covering more than 200,000 population with longitudinal follow-up 10 years. Propensity score matching applied identify two comparable cohorts statin users and non-statin users. Detailed information such...
Elevated homocysteine is an important risk factor that increases cerebrovascular and neurodegenerative disease morbidity. In mammals, B vitamin supplementation can reduce levels. Whether, how, hibernating essentially stop ingesting vitamins, maintain metabolism avoid impacts neurodegeneration remain unclear. Here, we compare levels in the brains of torpid bats, active bats rats to identify molecules involved homeostasis. We found does not elevate brains, despite declining At low B6 B12, no...
Background Inducing beige fat from white adipose tissue (WAT) is considered to be a shortcut weight loss and increasingly becoming key area in research into treatments for obesity related diseases. However, currently, animal models of are restricted rodents, where subcutaneous (sWAT, benign WAT) more liable develop the under specific activators than intra-abdominal (aWAT, malignant that major source diseases humans. Methods Here we induced by cold exposure two species bats, great roundleaf...
Traffic Matrix (TM), which records traffic volumes among network nodes, is important for operation and management. Due to cost issues, TMs cannot be directly measured collected in real time. Therefore, many studies work on predicting future based historical TMs. However, existing works are usually accuracy-centric prediction solutions that mainly focus improving accuracy of flows’ sizes (i.e., values elements TMs) without considering the practical application In this paper, we propose a...
Purpose The purpose of this paper is to analyze the organizational impacts enterprise mobility and configurations mobile information technology (IT) in companies with various value creation logics. Design/methodology/approach An exploratory approach combining semi-structured interview repertory grid method was used evaluate managers’ perspectives on effects technologies. Findings qualitative findings unearth about mobility, which are categorized into six intermediary dimensions two...
Abstract This study was aimed to determine plasma Pim‐1 levels in patients with pulmonary arterial hypertension ( PAH ) and estimate the clinical value of as a biomarker . single‐centre retrospective 111 congenital heart disease CHD idiopathic IPAH ). Those were divided into two groups: associated ‐ without nPAH Plasma measured by enzyme‐linked immunosorbent assay. (a) significantly increased compared healthy control group (27.81 ± 11.34 ng/mL vs 13.02 5.30 ng/mL; 32.81 12.28 ng/mL, P <...
Abstract Right heart failure and right ventricular (RV) remodeling were the main reason for mortality of pulmonary hypertension (PH) patients. Apolipoprotein AV (ApoA5) is a key regulator plasma triglyceride have multifunction in several target organs. We detected decreased ApoA5 serum patients with PH both RV monocrotaline‐induced model. Exogenously, overexpression by adenovirus showed protective effects on fibrosis secondary to PH. In addition, vitro experiments attenuated activation...
Pulmonary hypertension (PH) is a common complication in patients with end-stage renal disease (ESRD), especially hemodialysis (HD). Poor prognosis can eventually lead to right heart failure and even death. PH an independent risk factor for increased mortality ESRD patients. We should pay attention these clinic early detection, prevention treatment. The pathogenesis of still unclear so far, which might be related the increase pulmonary vascular resistance, blood flow, arterial wedge pressure....