A5018843822- COVID-19 epidemiological studies
- Viral Infections and Vectors
- COVID-19 diagnosis using AI
- Nutritional Studies and Diet
- COVID-19 Clinical Research Studies
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Influenza Virus Research Studies
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Herpesvirus Infections and Treatments
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- Inflammasome and immune disorders
- Food Safety and Hygiene
- FOXO transcription factor regulation
- Bariatric Surgery and Outcomes
- Streptococcal Infections and Treatments
- Construction Project Management and Performance
- Garlic and Onion Studies
- SARS-CoV-2 and COVID-19 Research
Hunan Normal University
2016-2024
Hunan Provincial People's Hospital
2016-2023
Dalian Municipal Central Hospital
2021
Dalian Medical University
2021
Nanjing General Hospital of Nanjing Military Command
2020
Hunan First Normal University
2020
Harbin Institute of Technology
2017
Central South University
2016
Hunan Mawangdui Hospital
2010-2014
Novartis (Switzerland)
2012
Abstract Varicella is an acute respiratory infectious diseases, with high transmissibility and quick dissemination. In this study, SEIR (susceptible-exposed-infected-recovered) dynamic model was established to explore the optimal prevention control measures according epidemiological characteristics about varicella outbreak in a school central city of China. Berkeley Madonna 8.3.18 Microsoft Office Excel 2010 software were employed for simulation data management, respectively. The result...
Ginsenoside-Rg1 (G-Rg1), a saponin that is primary component of ginseng, effective against inflammatory diseases. The P2X purinoceptor 7 (P2X7) receptor an ATP-gated ion channel predominantly expressed in immune cells and plays key role processes. We investigated the G-Rg1 sepsis-related cardiac dysfunction underlying mechanism involving regulation P2X7 receptor. detected cell viability, cytotoxicity, cellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) with...
Lipid metabolism plays an essential role in the genesis and progress of acute myocardial infarction (AMI). Herein, we identified verified latent lipid-related genes involved AMI by bioinformatic analysis. Lipid-related differentially expressed (DEGs) were using GSE66360 dataset from Gene Expression Omnibus (GEO) database R software packages. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses conducted to analyze DEGs. two machine learning techniques: least...
Mumps is an acute respiratory infectious disease with obvious regional and seasonal differences. Exploring the impact of climate factors on incidence mumps predicting its trend this basis could effectively control outbreak epidemic mumps. Considering great differences in vast territory China, study divided Chinese mainland into seven regions according to administrative planning criteria, data were collected from China Disease Prevention Control Information System, ARIMA model ARIMAX...
Aim: To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). Materials & methods: CapG expression and its correlation with clinicopathological characters patient prognosis were analyzed 76 cases PCa by immunohistochemistry qRT-PCR. Then, influence downregulation on cell apoptosis proliferation assessed. Results: was significantly higher compared those matched adjacent noncancerous tissues, correlated characters. Survival analysis indicated that could...
Hypertension is a major risk factor for cardiovascular diseases in China; hence, identifying good serum markers might provide cost benefits terms of reducing morbidity rates. In this population-based case-control study, participants were recruited from five districts Hunan province, and 416 cases matched with an equal number controls. Markers related to elevated blood pressure assessed: Body Mass Index, total cholesterol, triglycerides, fasting glucose, creatinine. Three potential...
Coronavirus disease 2019 (COVID-19) has been highly epidemic in China since January 2020. Rapid detection of the causative agent, severe acute respiratory coronavirus-2 (SARS-CoV-2), is very important due to its high rate infectivity. This study aimed clarify epidemiology and clinical characteristics COVID-19 outside Hubei province, China, optimize screening strategies for attempts contain spread virus. retrospective included all confirmed cases Hunan Provincial People's Hospital (Changsha,...
Abstract The role of RNA N6-methyladenosine (m6A) modification in the regulation immune microenvironment ischaemic cardiomyopathy (ICM) remains largely unclear. This study first identified differential m6A regulators between ICM and healthy samples, then systematically evaluated effects on characteristics ICM, including infiltration cells, human leukocyte antigen (HLA) gene, HALLMARKS pathways. A total seven key regulators, WTAP, ZCH3H13, YTHDC1, FMR1, FTO, RBM15 YTHDF3, were using a random...
Abstract Previous studies have explored the relationship between homocystein (Hcy) and lipid profiles. However, results from these been inconsistent. The current study investigated correlation Hcy profiles in Chinese community‐based population. participants were composed of 4012 people aged 30–92 years old, who recruited rural urban communities Hunan Province. Non‐parametric test logistic regression used to examine distribution (triglyceride [TG], total cholesterol [TC], low‐density...
Background: Previous studies demonstrate that T-cadherin is a candidate tumor suppressor in several types of human tumors, including non-small cell lung cancer (NSCLC). Lack protein expression by hypermethylation has been found to play an important role alveolar differentiation regulation and epithelial tumorigenesis. However, the correlation between clinicopathological characteristics NSCLC remains unclear. Here we conducted systematic review meta-analysis quantitatively evaluate effects on...
Typhoid fever and paratyphoid are one of the most criticial public health issues worldwide, especially in developing countries. The incidence this disease may be closely related to socio-economic factors, but there is a lack research on spatial level relevant determinants typhoid fever.In study, we took Hunan Province central China as an example collected data factors 2015-2019. Firstly mapping was made prevalence, again using geographical probe model explore critical influencing...
Abstract Background Recently, attention has focused on the impact of global climate change infectious diseases. Storm flooding is an extreme weather phenomenon that not only impacts health environment but also worsens spread pathogens. This poses a significant challenge to public security. However, there still lack research how different levels storm affect susceptible enteric diseases over time. Methods Data diseases, events, and meteorology were collected for Changsha, Hunan Province,...
This study retrospectively analyzed the spatio-temporal distribution and spatial clustering of scarlet fever in mainland China from 2004 to 2017. In recent years, incidence is increasing. Previous studies on are mainly focused at provincial municipal levels, there few systematic report temporal characteristics national level. Based information between 2017 collected Center for Disease Control, this paper systematically explored Spatio-temporal by three methods, contains autocorrelation...
Chickenpox is a common acute and highly contagious disease in childhood; moreover, there currently no targeted treatment. Carrying out an early warning on chickenpox plays important role taking measures advance as well preventing the outbreak of disease. In recent years, infectious dynamic model has been widely used research various diseases. The logistic differential equation can demonstrate epidemic characteristics outbreaks, gives point at which rate changes from slow to fast. Therefore,...
ABSTRACT Hypertension is a major cause of premature death in China. Understanding risk factors including behavioural and predisposing may help to prevent development hypertension control the extent mortality. In this case-control design conducted Hunan province, 416 hypertensive subjects were matched with an equal number normotensive persons from nearly 9,000 volunteers. A self-report questionnaire was employed collect demographic lifestyle information, fasting serum biomarkers related lipid...
Influenza is a worldwide public health problem which causes serious economic and burden. In order to provide scientific basis for improving the prevention control level of influenza, using dynamic model evaluate infection rates influenza different subtypes from 2010 2019 in China.This article established SEIABR based on cases reported by China National Center 2019. And calculated transmission rate Re combined natural birth rate, death infectious proportion asymptomatic patients, untreated...
<title>Abstract</title> <bold>Background</bold>: Previous studies have examined the relationship between hypertension or homocysteine and chronic kidney disease (CKD). However, H-type CKD remains uncertain. The aim of this study was to investigate provide a scientific basis for prevention treatment CKD; <bold>Methods</bold>: This case-control included 514 subjects, 257 in each case control groups. diagnostic criteria were structural functional abnormalities kidneys ≥ 3 months, which may not...