A5038209277- Sperm and Testicular Function
- Reproductive Health and Technologies
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Trace Elements in Health
- Reproductive Biology and Fertility
- Demographic Trends and Gender Preferences
- Effects and risks of endocrine disrupting chemicals
- COVID-19 Clinical Research Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Toxic Organic Pollutants Impact
- Water Treatment and Disinfection
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Health and Contraception
- Hippo pathway signaling and YAP/TAZ
- Neurological Disease Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Magnesium in Health and Disease
- Phytochemistry Medicinal Plant Applications
- Sleep and related disorders
- Global Health and Surgery
- Tea Polyphenols and Effects
Fujian Medical University
2021-2025
Huazhong University of Science and Technology
2017-2023
First Affiliated Hospital of Fujian Medical University
2021-2023
Hubei University of Medicine
2022
Ministry of Ecology and Environment
2019
Hunan Normal University
2016
Hunan Provincial People's Hospital
2016
Air Force Medical University
2011-2012
Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a pandemic affecting over 200 countries. Many cities have established designated fever clinics to triage suspected COVID-19 patients from other with similar symptoms. However, given the limited availability of nucleic acid test as well long waiting time for both and radiographic examination, quarantine or therapeutic decisions large number mixed were often not made in time. We...
A growing body of evidence has found links between endocrine disruptor phthalates and male reproductive disorders, but the mechanisms underlying these relationships are poorly known. Seminal plasma metabolomes may mediate associations phthalate exposure with impaired semen quality.To identify seminal associated poor quality evaluate their urinary metabolites among 660 Chinese adult men.The metabolic profiles were acquired using an untargeted approach based on liquid chromatography-high...
Short sleep duration and poor quality are increasingly prevalent in modern society may be associated with impaired semen quality, yet studies inconclusive. To investigate the reproducibility of parameters among 842 healthy men screened as potential sperm donors explore associations repeated measures parameters. We assessed (night daytime napping) using Pittsburgh Sleep Quality Index (PSQI) screen donors. examined characteristics relation to measurements (n = 5601) linear mixed-effects...
Abstract STUDY QUESTION Is physical activity or sedentary time associated with semen quality parameters? SUMMARY ANSWER Among healthy men screened as potential sperm donors, higher self-reported was increased progressive and total motility. WHAT IS KNOWN ALREADY Despite the claimed beneficial effect of moderate on quality, results from epidemiological studies have been inconclusive. Previous were mostly conducted among endurance athletes male partners couples who sought infertility...
Abstract Background Magnesium (Mg) is both an essential macro-element and a known catalyst, it plays vital role in various physiological activities mechanisms relation to chronic kidney disease (CKD). However, epidemiological evidence involving this limited not entirely consistent. This study aims explore the association of serum Mg concentrations with risk CKD among general Chinese adults. Methods A total 8,277 adults were included wave 2009 from China Health Nutrition Survey (CHNS). The...
Toxicological studies revealed that exposure to organophosphate esters (OPEs) affects semen quality, but human evidence is controversial. Over a 3-month follow-up, 1,385 healthy young men provided 3,550 urine samples and 6,466 samples, which were determined for urinary OPE metabolite concentrations, sperm quality parameters, mitochondrial DNA copy number (mtDNAcn). Linear mixed models inverse associations between diphenyl phosphate (DPHP) concentrations concentration [−3.81% (95% CI: −6.31,...
Essential elements such as iron (Fe), cobalt (Co), copper (Cu), zinc (Zn), selenium (Se), rubidium (Rb), strontium (Sr), and molybdenum (Mo) are necessary for reproductive health. However, their associations with human semen quality remain inconclusive. To investigate the of urinary Fe, Co, Cu, Zn, Se, Rb, Sr, Mo concentrations in healthy men screened potential sperm donors identify critical windows susceptibility. 1428 provided 3766 urine 6527 samples, which were measured essential element...
Trihalomethanes (THMs) have demonstrated adverse effects on male reproductive systems in experimental animals, but human evidence has been inconsistent. Prior researches limited by small sample sizes and inadequate exposure assessment.To investigate the association between blood THMs repeated measurements of semen quality parameters among 1199 healthy men screened as potential sperm donors.We recruited presenting to Hubei Province Human Sperm Bank from April December 2017. At study entry,...
Selenium (Se) is essential for successful male reproduction. However, the association of Se status with human semen quality remains controversial and underlying mechanisms are poorly understood. We measured seminal plasma concentrations, sperm mitochondrial DNA copy number (mtDNAcn), parameters among healthy Chinese men screened as potential donors. Linear mixed-effects models were used to investigate associations within-subject pooled concentrations (n = 1159) repeated 5617); mediation...
Aim: To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). Materials & methods: CapG expression and its correlation with clinicopathological characters patient prognosis were analyzed 76 cases PCa by immunohistochemistry qRT-PCR. Then, influence downregulation on cell apoptosis proliferation assessed. Results: was significantly higher compared those matched adjacent noncancerous tissues, correlated characters. Survival analysis indicated that could...
Abstract Evaluation of Cr, Mn, Fe, Zn and Se in humans is challenged by the potentially high within-individual variability these elements biological specimens, which are poorly characterised. This study aimed to evaluate their within-day, between-day between-month spot samples, first-morning voids 24-h collections. A total 529 urine samples (including eighty-eight collections) were collected from eleven Chinese adult men on days 0, 1, 2, 3, 4, 30, 60 90 analysed for five using inductively...
To investigate the association between mitochondrial DNA copy number (mtDNAcn) and semen quality.A cross-sectional study.Hubei Province Human Sperm Bank of China (from April 2017 to July 2018).A total 1164 healthy male sperm donors with 5739 specimens.Real-time quantitative polymerase chain reaction (RT-PCR) was used measure mtDNAcn. We also determined volume, concentration motility parameters (progressive motility, nonprogressive immotility).Mixed-effect models general linear were...
While exogenous metal/metalloid (metal) exposure has been associated with reduced human semen quality, no study assessed the associations of metals in spermatozoa quality. Here, we developed a strategy to explore between at single-cell resolution and quality among 84 men screened as sperm donors, who provided 266 samples within 90 days. A cellular atlas level was created mass cytometry (CyTOF) technology, which concurrently displayed 18 more than 50 000 single sperm. Exogenous were extremely...
The longitudinal immunologic status of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients and its association with the clinical outcome are barely known. Thus, we sought to analyze temporal profiles specific antibodies, as well associations between proinflammatory cytokines, survival disease 2019 (COVID-19). A total 1830 laboratory-confirmed COVID-19 cases were recruited. virus, cytokines until 12 weeks since illness onset fitted by locally weighted scatter plot...