A5085323287- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Per- and polyfluoroalkyl substances research
- Heavy metals in environment
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Climate Change and Health Impacts
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Microplastics and Plastic Pollution
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Gestational Diabetes Research and Management
- Radioactivity and Radon Measurements
- Energy and Environment Impacts
- Chemical Analysis and Environmental Impact
- Selenium in Biological Systems
- Mercury impact and mitigation studies
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Pharmaceutical and Antibiotic Environmental Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
Xiamen University
2019-2025
Institute of Urban Environment
2015-2024
Chinese Academy of Sciences
2015-2024
Children’s Hospital of Fudan University Xiamen Branch
2022-2024
COMSATS University Islamabad
2016-2022
University of Central Punjab
2022
Nike (United States)
2022
Epistem (United Kingdom)
2022
Aristotle University of Thessaloniki
2022
University of Chinese Academy of Sciences
2017-2021
Fifty million to 60 people potentially exposed high levels of groundwater arsenic, which is coincident with areas irrigation.
Microplastic (MP) is an emerging environmental pollutant and exposure to MPs has been associated with numerous adverse health outcomes in both wild laboratory animals. The toxicity of depends on concentration, time, chemical composition size distribution, but the impacts particle remain inconclusive yet. In this study, adult marine medaka (Oryzias melastigma) were exposed different polystyrene (PS-MPs) concentration 10 mg/L for 60 days growth performance, lipid metabolism, immune parameters...
Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal 27 organochlorine compounds used as and cryptorchidism among children.Within prospective birth cohort, we performed case-control study; 62 milk samples from mothers of cryptorchid boys 68 healthy were selected. Milk was collected individual pools 1 3 months postpartum analyzed for pesticides.Eight measurable all (medians; nanograms per...
Bisphenol A (BPA) is widely used in plastic products, through which humans are exposed to it. Accumulating evidence suggests that BPA exposure associated with β-cell dysfunction. Mitochondrial defects can cause impairment and failure of β cells, but there little information about the effects on mitochondrial function cells. In this study, we assessed role mitochondria-mediated mechanisms underlying BPA-induced dysfunction resulting apoptosis. INS-1 cells were cultured 0, 0.0020, 0.020, 0.20,...
To investigate the hypothesis that general environmental arsenic (As) exposure can impair male fertility, we designed a case-control study examining possible correlations between concentrations of different As species in urine [controls (n = 151) vs cases 140)], urinary metabolic biomarkers 158) 135)], and infertility characterized by poor semen quality. Regional participants were recruited sequentially from affiliated hospitals Nanjing Medical University. Elevated inorganic arsenate...
Abstract Arsenic is a widespread metalloid in environment, whose exposure has been associated with broad spectrum of toxic effects. However, global view arsenic-induced male reproductive toxicity still lack, and the underlying mechanisms remain largely unclear. Our results revealed that arsenic decreased testosterone level reduced sperm quality rats. By conducting an integrated proteomics metabolomics analysis, present study aims to investigate influence on proteome metabolome rat testis....
Environmental pollutant exposure may play certain roles in the pathogenesis and progression of diabetes mellitus including gestational (GDM). We hypothesize that heavy metal trigger GDM during pregnancy. The objective this study was to investigate possible associations between selected risk.This investigation is a retrospective case-control nested within cohort 1359 pregnant women. These participants were recruited Xiamen Maternity Child Care Hospital, China, June July, 2012. All their...
Abstract Background Recent observations in vitro and vivo models suggest that arsenic (As) is an endocrine disruptor at environmentally-relevant levels. When exposed to As, male rats mice show steroidogenic dysfunction can lead infertility. However, the possible effects of As on human semen quality remain obscure. Methods We monitored profile species urine a reproductive-age cohort assessed its association with quality. Men ( n = 96) were recruited infertility clinic from July 2009 August...
Urinary biomonitoring provides the most accurate arsenic exposure assessment; however, to improve risk assessment, arsenic-related metabolic biomarkers are required understand internal processes that may be perturbed, which may, in turn, link a specific health outcome. This study aimed investigate urinary metabolome changes and identify dose-dependent as proof-of-concept of information could obtained by combining metabolomics targeted analyses. species such inorganic arsenic, methylarsonic...
Exposure to airborne particulate matter (PM)2.5, a PM with aerodynamic diameter of less than 2.5 µm, is known be associated variety adverse health effects. However, the molecular mechanisms involved in fine toxicity are still not well characterized. The present study aims provide new insights into cytotoxicity PM2.5 on human lung epithelial cells (A549) at proteomic level. Two-dimensional difference gel electrophoresis revealed total 27 protein spots, whose abundance were significantly...
A growing body of evidence has found links between endocrine disruptor phthalates and male reproductive disorders, but the mechanisms underlying these relationships are poorly known. Seminal plasma metabolomes may mediate associations phthalate exposure with impaired semen quality.To identify seminal associated poor quality evaluate their urinary metabolites among 660 Chinese adult men.The metabolic profiles were acquired using an untargeted approach based on liquid chromatography-high...