Abstract Varicella is an acute respiratory infectious diseases, with high transmissibility and quick dissemination. In this study, SEIR (susceptible-exposed-infected-recovered) dynamic model was established to explore the optimal prevention control measures according epidemiological characteristics about varicella outbreak in a school central city of China. Berkeley Madonna 8.3.18 Microsoft Office Excel 2010 software were employed for simulation data management, respectively. The result...

Mumps is an acute respiratory infectious disease with obvious regional and seasonal differences. Exploring the impact of climate factors on incidence mumps predicting its trend this basis could effectively control outbreak epidemic mumps. Considering great differences in vast territory China, study divided Chinese mainland into seven regions according to administrative planning criteria, data were collected from China Disease Prevention Control Information System, ARIMA model ARIMAX...

The aim of the present study was to discuss a novel method for detection malignant tumor cells in cerebrospinal fluid (CSF), by observing marker-immunostaining fluorescence situ hybridization (TM-iFISH) enrichment and counting CSF patients with lung cancer leptomeningeal metastasis (LM). A total 10 samples were collected from 6 that presented LM. For each patient, 20 ml obtained through lumbar puncture, which 7.5 used count number using TM-iFISH enrichment. Cytological biochemical...

Objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and factors hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour dietary factors. Design Population-based cross-sectional study. Setting Hunan Province, China Participants A total of 4012 participants completed study, between July 2013 March 2014. The median age 55 (interquartile range: 45–63) years, with 1644 males (41%) 2368...

Objective To assess whether cumulative exposure of unhealthy lifestyles is associated with HTH in Chinese adults and to explore the combination lifestyles. Methods This study combined a community-based cross-sectional 1:1 matched case–control using propensity scores among six randomly selected districts from Hunan Province, China. We recruited 5,258 people, whom 4,012 met criteria. Lifestyles personal characteristics were collected by questionnaire. Lifestyle score was calculated cigarette...

Abstract Objective To assess circulating tumor cells in cerebrospinal fluid as a diagnostic approach to identify meningeal metastasis patients with non-small cell lung cancer by using marker immunostaining–fluorescence situ hybridization (TM-iFISH). Methods In 5 who were confirmed have developed cytology, 20 ml of was obtained through lumbar puncture, from which 7.5 utilized for TM-iFISH and quantitate cells, 10ml 2.5ml detection markers. Results examination identified 18 1,823 per 7.5ml...

To investigate the detection value of tumor cells in cerebrospinal fluid (CSF) adjuvant diagnosis meningeal metastasis from lung cancer by immunofluorescence situ hybridization (immuno-FISH) technology. The circulating (CTCs) CSF 16 patients with and 8 non-tumor diseases brain were detected using immuno-FISH was based on neurological symptoms, enhanced magnetic resonance imaging (MRI) scans cytological examination. number CTCs significantly higher than those (P<0.01). critical point maximum...

The calY gene, encoding metalloprotease camelysin in the Bacillus thuringiensis acrystalliferous strain XBU001, was amplified and sequenced. from sequence 199 amino acids size (c. 22 000 Da). temperature-sensitive plasmid pKESX used to construct a camelysin-deficient of B. thuringiensis. gene replaced by an erythromycin-resistant KCTF. Sodium dodecyl sulfate polyacrylamide gel electrophoresis MS analysis showed that InhA not expressed after knocking out calY. pKPC complementation KCTFC....

This study aimed to investigate the diagnostic value of calcification detected by computed tomography (CT) for differentiation benign and malignant thyroid nodules. is a retrospective 930 consecutive patients (709 women, 221 men; mean age 51 years) with pathologically proven The characteristics on CT images were correlated pathological results. A total 168 diagnosed carcinomas 762 Calcification was found in 231 cases (24.84%). incidence significantly higher carcinoma (52.38%) than those...

Chickenpox is a common acute and highly contagious disease in childhood; moreover, there currently no targeted treatment. Carrying out an early warning on chickenpox plays important role taking measures advance as well preventing the outbreak of disease. In recent years, infectious dynamic model has been widely used research various diseases. The logistic differential equation can demonstrate epidemic characteristics outbreaks, gives point at which rate changes from slow to fast. Therefore,...

Lung cancer is one of the most common malignant tumors in China. The aim this study to observe efficacy and safety recombinant human vascular endostatin (endostar) durative transfusion combined with window period arterial infusion chemotherapy treatment advanced lung squamous carcinoma.From February 2014 January 2015, 10 cases cytological or histological pathology diagnosed stage IIIb - IV carcinoma were treated (30 mg/d) chemotherapy. Over same patients for pure perfusion compared....

Juvenile hormone (JH) is one of the key insect hormones that regulate metamorphosis. diol kinase (JHDK) an enzyme involved in JH metabolism and catalyzes to form a polar end product, phosphate has no activity. In this study, JHDK complementary DNA (cDNA) was cloned from Spodoptera litura structure expression gene characterized. The cDNA 714 base pairs length encoded protein 183 amino acids with molecular mass 21 kDa isoelectric point 4.55. Based on structure, three putative calcium binding...

Abstract Objective To discuss the application of ARMS method to detect EGFR gene mutation in cerebrospinal fluid lung adenocarcinoma patients with meningeal metastasis. Methods 5 cases were identified metastasis that cleared by sequencing method. From each patient 5ml was obtained lumbar puncture. used mutations fluid. Results samples successfully detected method, 3 found mutations, line direct Conclusion can be But specimens from histological specimens, blood need confirmed further...

<b>Objective:</b> The purpose of this study was to evaluate the clinical efficacy super-selective intracranial artery infusion chemotherapy and determine correlated prognostic parameters for advanced lung cancer patients with brain metastases. <b>Patients Methods:</b> Fifty-four metastasis who had no previous treatment were enrolled study. These received chemotherapy, as well arterial primary metastatic lesions. procedure performed once every 4 weeks. Patients monitored short-term outcomes...

Thyroid cancer is the most common endocrine malignancy, with an increasing prevalence worldwide. Poorly-differentiated thyroid (PDTC) relatively rare and its prognosis poor. To date, no ideal treatment strategy available for patients advanced recurrent PDTC, particularly in crisis. However, partial success treating has been achieved targeted therapy, advances made understanding molecular biology of tumor. The current study describes case a patient diagnosed PDTC following presentation...

Abstract Background: KN026 is a novel bispecific HER2-targeted antibody. Fully humanized, IgG1-like antibody binds to two distinct HER2 epitopes, the same domains as trastuzumab and pertuzumab. Preliminary safety efficacy results (data of Aug 18, 2022) were presented at SABCs 2022(PD18-08), showed promising tolerability. Herein, we update 2.5-year follow-up results. Methods: Eligible subjects with recurrent/metastatic breast cancer, HER-2 positive treatment-naive enrolled. Subjects received...

Background and importanceExplore the techniques, advantages disadvantages of 3D Slicer reconstruction combined with transcranial neuroendoscopy in cerebrospinal fluid rhinorrhea surgery.Clinical presentationWe collected complete clinical data two patients who underwent minimally invasive surgery using through supraorbital eyebrow arch keyhole approach our hospital from June 2022 to May 2023. The were one male female, aged 50 63 years old. At same time, a retrospective summary relevant...

With the increasing impact of tuberculosis on public health, accurately predicting future cases is crucial for optimizing health resources and medical service allocation. This study applies a self-attention mechanism to predict number cases, aiming evaluate its effectiveness in forecasting. Monthly case data from Changde City between 2010 2021 were used construct model, long short-term memory (LSTM) an autoregressive integrated moving average (ARIMA) model. The performance these models was...