A5100710919- Insect Resistance and Genetics
- Respiratory viral infections research
- Lysosomal Storage Disorders Research
- Entomopathogenic Microorganisms in Pest Control
- Cellular transport and secretion
- Ion channel regulation and function
- Insect and Pesticide Research
- Cerebral Palsy and Movement Disorders
- Ginkgo biloba and Cashew Applications
- Breast Cancer Treatment Studies
- Asthma and respiratory diseases
- Caveolin-1 and cellular processes
- Magnesium in Health and Disease
- Signaling Pathways in Disease
- Neural and Behavioral Psychology Studies
- Neonatal and fetal brain pathology
- Ion Channels and Receptors
- biodegradable polymer synthesis and properties
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Plant Stress Responses and Tolerance
- Breast Lesions and Carcinomas
- Atherosclerosis and Cardiovascular Diseases
- Nuclear Receptors and Signaling
Renmin Hospital of Wuhan University
2024
Wuhan University
2024
University of Illinois Chicago
2019-2024
Zhejiang Business Technology Institute
2021-2024
Chifeng Municipal Hospital
2024
University of Toronto
2003-2023
Ted Rogers Centre for Heart Research
2022-2023
Second Military Medical University
2023
University of Chinese Academy of Sciences
2023
ShanghaiTech University
2023
Abstract Metal–organic frameworks (MOFs) are one of the most promising membrane materials for olefin/paraffin separations. However, MOF membranes have a thickness over 1 µm, which greatly compromises permeation flux. While previous studies focused on increasing crystal nucleus density substrates, achieving ultrathin via modulation growth is lacking. Herein, an inhibited Ostwald ripening (IOR) strategy proposed to fabricate ZIF‐8 membranes, through incorporating polymer‐based inhibitors into...
APH-1 and PEN-2 genes modulate the function of nicastrin presenilins in <i>Caenorhabditis elegans</i>. Preliminary studies transfected mammalian cells overexpressing tagged proteins suggest that this genetic interaction is mediated by a direct physical interaction. Using protein encoded on human chromosome 1 (APH-1<sub>1</sub>L; also known as APH-1a) an archetype, we report here endogenous forms are predominantly expressed intracellular membrane compartments, including endoplasmic reticulum...
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit development and/or progression. Studies were performed to determine the effects a model statin, atorvastatin (ATO), on proliferation differentiation cells, identify possible mechanisms ATO action. inhibited in vitro both LNCaP PC3 human cells dose- time-dependent fashion. greater inhibitory activity was associated with induction autophagy cell line, as...
Niemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive, lethal, lysosomal disease characterized by progressive cerebellar ataxia and cognitive impairment. Although the NPC1 phenotype heterogeneous with variable age of onset, classical a pediatric disorder. Currently there are no therapies approved FDA therapeutics trials for complicated rarity, heterogeneity, relatively slow rate neurological decline. Thus, identification relevant biomarkers necessary to provide tools that can...
Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) by direct binding and is superinhibitory if it binds as a binary complex with phospholamban (PLN). To demonstrate whether overexpression of SLN in heart might impair function directly, transgenic (TG) mice cardiac-specific NF-SLN (SLN tagged at its N terminus FLAG epitope) were generated on (PLN) null (PLN KO) background. In TG/PLN KO microsomes, apparent affinity SERCA2a for was decreased compared...
In‐depth proteomic analyses offer a systematic way to investigate protein alterations in disease and, as such, can be powerful tool for the identification of novel biomarkers. Here, we analyzed data from transgenic mouse model with cardiac‐specific overexpression activated calcineurin ( C n A ), which results severe cardiac hypertrophy. We applied statistically filtering and false discovery rate correction methods identify 52 proteins that were significantly different hearts compared...
The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease etiology, yet the majority underlying signaling mechanisms are complex not fully elucidated. Phosphorylation is a major point protein regulation with rapid profound effects function activity networks. Currently, there lack comprehensive proteomic phosphoproteomic studies examining cardiac tissue from HF either dilated cardiomyopathy (DCM) or ischemic (ICM). Here, we used combined approach to identify...
Purpose: Perceived discrimination among higher vocational college students is a prevalent issue in China and linked to various mental behavioral problems, including mobile phone addiction. Yet, the mechanisms underlying relationship between perceived addiction remain ambiguous. Methods: To address this issue, we recruited 1253 elucidate Participants completed series of self-report questionnaires assessing discrimination, addiction, negative emotions, learning burnout. Results: Our findings...
Abstract Background To investigate the trend of refractive error among elementary school students in grades 1 to 3 Hubei Province, analyze relevant factors affecting myopia progression, and develop a model predict progression risk developing high children. Methods Longitudinal study. Using cluster-stratified sampling method, (15,512 total) from 17 cities Province were included as study subjects. Visual acuity, cycloplegic autorefraction, height weight measurements performed for three...
Several lines of evidence have indicated that the presenilin proteins function within macromolecular complexes and are necessary for regulated intramembranous proteolysis certain type 1 transmembrane proteins, including amyloid precursor protein, Notch, p75. Data from multiple complementary experiments now suggest there may be several distinct complexes. We show here mutations detergents affect abundance componentry complexes, these structural effects correlate with their on γ-secretase...
The ryanodine receptor (RyR) is a large, homotetrameric sarcoplasmic reticulum membrane protein that essential for Ca(2+) cycling in both skeletal and cardiac muscle. Genetic mutations RyR1 are associated with severe conditions including malignant hyperthermia (MH) central core disease. One phosphorylation site (Ser 2843) has been identified segment of flanked by two RyR motifs, which found exclusively all isoforms as closely tandem (or paired) named after the itself. These motifs also...
Objective. Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated effect and mechanisms of puerarin on diabetic aorta in rats. Methods. Streptozotocin- (STZ-) induced rats were administered with for 3 weeks. Levels serum insulin (INS), PGE2, endothelin (ET), glycated hemoglobin (GHb), H 2 O , nitric oxide (NO) measured by ELISA colorimetric assay kits. The aortas stained H&E. Moreover, mRNA expression ICAM-1, LOX-1, NADPH oxidase (NOX2), NOX4...
Sarcolipin (SLN) and phospholamban (PLN) are effective inhibitors of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA). These homologous proteins differ at their N C termini: C-terminal Met-Leu-Leu in PLN is replaced by Arg-Ser-Tyr-Gln-Tyr SLN. The role sequence SLN tagged N-terminally with FLAG epitope (NF-SLN) endoplasmic (ER) retention was investigated transfecting human embryonic kidney-293 cells cDNAs encoding NF-SLN or a series mutants which amino acids were deleted progressively....
NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating efflux. Mutations the NPC1 gene result Niemann-Pick disease, type C (NPC), fatal, lysosomal storage disease. Due to progressively expanding implications of NPC1-related disorders, we investigated endogenous protein–protein interactions mouse cortex and human-derived iPSCs neuronal models disease through coimmunoprecipitation-coupled with LC-MS based...
Oral squamous cell carcinomas (OSCC) induced in F344 rats by 4-nitroquinoline-1-oxide (4-NQO) demonstrate considerable phenotypic similarity to human oral cancers. Gene expression studies (microarray and PCR) were coupled with methylation analysis of selected genes identify molecular markers carcinogenesis this model potential biochemical targets for cancer chemoprevention. Microarray 11 pairs OSCC site-matched phenotypically normal tissues from 4-NQO-treated identified more than 3500...
Capsular covalent organic frameworks (COFs) offer unique and highly tunable spaces for enzyme immobilization. Herein, a kind of bioactive framework (bio-COF) capsule was fabricated through sacrificial templating method the synthesis lactate from pyruvate. The time COF amount were optimized during preparation bio-COF capsules. enzymes entrapped in wall with thickness ∼240 nm major pore size ∼1.8 nm. porous structure capsules ensured rapid diffusion substrates wall. Thereby, retained 70% its...
Abstract Background Saccharopolyspora spinosa produces the environment-friendly biopesticide spinosad, a mixture of two polyketide-derived macrolide active ingredients called spinosyns A and D. Therefore considerable interest is in improvement spinosad production because its low yield wild-type S. . Recently, spinosad-hyperproducing PR2 strain with stable heredity was obtained from protoplast regeneration SP06081 strain. comparative proteomic analysis performed on strains during first rapid...
Previous studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types human cancer. However, there are few reporting the level miR‑124a expression in non‑small cell lung cancer (NSCLC). The present study investigated association between and NSCLC by analyzing differential using GEO database, as well subsequently performing reverse transcription‑quantitative polymerase chain reaction analysis on 160 biopsies, 32 which were paired adjacent normal tissues....