A5100386915- Ubiquitin and proteasome pathways
- Spine and Intervertebral Disc Pathology
- Surgical Simulation and Training
- Multimodal Machine Learning Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- 3D Printing in Biomedical Research
- Recommender Systems and Techniques
- Nerve Injury and Rehabilitation
- Spinal Fractures and Fixation Techniques
- Mesenchymal stem cell research
- Metabolomics and Mass Spectrometry Studies
- Cervical and Thoracic Myelopathy
- Electromagnetic wave absorption materials
- Spinal Cord Injury Research
- RNA Interference and Gene Delivery
- Peripheral Nerve Disorders
- Traditional Chinese Medicine Analysis
- Musculoskeletal pain and rehabilitation
- Digital Media Forensic Detection
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
Qiqihar Medical University
2025
Chengdu University of Technology
2025
China University of Geosciences
2024
Beijing University of Chinese Medicine
2014-2024
Capital Medical University
2021-2024
Jilin Agricultural University
2022-2024
China Medical University
2012-2024
Second Affiliated Hospital of Jilin University
2018-2024
Liaoning University of Traditional Chinese Medicine
2024
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2024
Abstract Spinal cord injury (SCI) is a catastrophic to the central nervous system (CNS) that can lead sensory and motor dysfunction, which seriously affects patients' quality of life imposes major economic burden on society. The pathological process SCI divided into primary secondary injury, cascade amplified responses triggered by injury. Due complexity mechanisms SCI, there no clear effective treatment strategy in clinical practice. Exosomes, are extracellular vesicles endoplasmic origin...
Porcine Schwann cells and neuronal analogue NG108-15 were printed using a piezoelectric-inkjet-printer within the range of 70V to 230V, with analysis viability quality after printing.Neuronal glial cell viabilities >86% >90% detected immediately printing no correlation between voltage applied could be seen.Printed shown produce neurites earlier compared controls, over several days, produced longer which become most evident by day 7.The number becomes similar 7 also, proliferate that...
Generative models have been widely studied in computer vision. Recently, diffusion drawn substantial attention due to the high quality of their generated images. A key desired property image generative is ability disentangle different attributes, which should enable modification towards a style without changing semantic content, and parameters generalize Previous studies found that adversarial networks (GANs) are inherently endowed with such disentanglement capability, so they can perform...
Little is currently known about the effect of smoking on osteoarthritis (OA). This study aimed to investigate relationship between and OA in United States (US) general population. Cross-sectional study. Level evidence, 3. 40,201 eligible participants from National Health Nutrition Examination Survey 1999-2018 were included divided into non-arthritis groups. Participants demographics characteristics compared two Then non-smokers, former smokers, current smokers based their status, also among...
Abstract Neurotrauma, encompassing traumatic brain injuries (TBI) and spinal cord (SCI) impacts a significant portion of the global population. While spontaneous recovery post-TBI or SCI is possible, recent advancements in cell-based therapies aim to bolster these natural reparative mechanisms. Emerging research indicates that beneficial outcomes such might be largely mediated by exosomes secreted from administered cells. stem cells have garnered much attention, derived non-stem cells,...
Angiogenesis and osteogenesis have been considered as inseparable critical processes for bone formation fracture healing. One promising strategy to improve the capability of angiogenesis on a titanium (Ti) surface involves fabrication stable multifunctional release interfaces. This study developed combined sequential bio-interfacial system with basic fibroblast growth factor (bFGF) morphogenetic protein 2 (BMP-2) using polydopamine (PDA) coating Ti enhance osteogenesis. Their surfaces were...
Spinal cord injury (SCI) compromises the blood-spinal barrier (BSCB) and induces neuroinflammation, potentially exacerbating neuronal damage. This underscores importance of maintaining BSCB integrity mitigating neuroinflammation in SCI treatment. Our study explores an innovative approach to treating by utilizing platelet-rich plasma-derived exosomes (PRP-Exos) stabilize function alleviate neuroinflammation. We successfully isolated from plasma conducted both vivo vitro experiments assess...
Background Our study was aimed at detecting the expression levels of miR‐206 in prostate cancer (PCa) tissues and PCa cell lines, exploring potential functions by targeting chemokine ligand 11 ( CXCL11 ). Methods RT‐qPCR applied to detect expressions lines. Expression protein detected using Western blot. After manipulating PC‐3 DU‐145 cells, changes proliferation cycle were observed through counting kit‐8 (CCK‐8) flow cytometry. Wound healing transwell assay conducted for migration invasion...
Abnormal vascular smooth muscle cell (VSMC) proliferation has an important role in the pathogenesis of both atherosclerosis restenosis and hypertension. Vascular endothelial growth factor (VEGF) been shown to stimulate VSMC proliferation. In addition, angiogenesis is one hallmarks cancerous growth. VEGF key modulator for initial stages that acts through endothelial‐specific receptor tyrosine kinases (VEGFRs). VEGFR‐2 blockage a good approach suppression angiogenesis. order discover novel TK...
Ferroptosis is a newly discovered type of cell death and has recently been shown to be associated with asthma. However, the relationship between them at genetic level not elucidated via informatics analysis. In this study, bioinformatics analyses are conducted using asthma ferroptosis datasets identify candidate ferroptosis-related genes R software. Weighted gene co-expression network analysis performed co-expressed genes. Protein-protein interaction networks, Kyoto encyclopedia genomes,...
Abstract China’s higher education system is shifting from quantitative expansion to connotative development advance its quality. Since 2015, Chinese governments have been implementing a strategic policy for called “double first-class”, which aims promote number of top universities construct world-class or establish disciplines. “Double first-class” received large amount educational resources through this policy. Taking advantage efficiently an important element in promoting the quality...
Abstract Background Hepatitis B virus (HBV) X protein (HBX) has been reported to be responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular carcinoma (HCC). Vimentin is an EMT-related molecular marker. However, importance of vimentin pathogenesis HCC mediated by HBX not well determined. Methods The expression induced HBX, and role LIM SH3 domain 1 (LASP1) HBX-induced hepatoma cells were examined western blot immunohistochemistry analysis. Both signal...
There is a limited understanding of the risk factors for lumbar disc herniation (LDH) in younger people, even though evidence suggests that LDH more prevalent this population. This study aimed to comprehensively analyze adolescents and young adults.
In order to perfect the design strategy of messenger RNA (mRNA) vaccines against H5N1 influenza virus, we investigated whether different antigen designs and use adjuvants could improve immune effect mRNA vaccines. We designed three forms genes, including Flu [H1/H3/H5/B-HA2(aa90~105)-M2e(24aa)], Flu-Fe (Fe, ferritin), CD5-Flu-Fe (CD5, a secretion signal peptide). Meanwhile, R848 (Requimod) was selected as adjuvant vaccine. prepared cationic lipid nanoparticles for delivery, named LNP-Man...
Objective: This study explored the multicomponent, multitarget, and multipathway mechanism of Danhe granules (DG) against hyperlipidemia through network pharmacology. The relevant targets pathways were verified by preliminary experiments. Methods: active components DG selected TCMSP TCMIP database, component-target diagram was constructed Cytoscape 3.7.1. protein–protein interaction core screened out STRING11.0 database. Metascape database 3.7.1 used to enrich target establish a model in...
Interactive recommendation with natural-language feedback can provide richer user and has demonstrated advantages over traditional recommender systems. However, the classical online paradigm involves iteratively collecting experience via interaction users, which is expensive risky. We consider an offline interactive to exploit arbitrary collected by multiple unknown policies. A direct application of policy learning such fixed suffers from distribution shift. To tackle this issue, we develop...