A5100373348- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- interferon and immune responses
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- RNA regulation and disease
- HIV Research and Treatment
- MicroRNA in disease regulation
- Cellular Mechanics and Interactions
- Diet and metabolism studies
- Melanoma and MAPK Pathways
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Gut microbiota and health
- Endoplasmic Reticulum Stress and Disease
- Autoimmune and Inflammatory Disorders Research
- Mycobacterium research and diagnosis
- Cell death mechanisms and regulation
China Medical University
2024
Xuzhou Medical College
2014-2023
Jiangsu University of Science and Technology
2023
Fuzhou Second Hospital
2022
Xiamen University
2022
Fujian Medical University
2022
Suzhou Institute of Biomedical Engineering and Technology
2022
University of Science and Technology of China
2022
Tianjin University of Traditional Chinese Medicine
2022
Icahn School of Medicine at Mount Sinai
2021-2022
Interleukin 17 (IL-17), produced mainly by T helper (Th17) cells, is increasingly recognized as a key regulator in various autoimmune diseases, including human multiple sclerosis (MS) and its animal model, experimental encephalomyelitis (EAE). Although several microRNAs (miRNAs) with aberrant expression have been shown to contribute the pathogenesis of MS EAE, mechanisms underlying regulation abnormal miRNA astrocytes upon IL-17 stimulation remain unclear. In present study, we detected...
Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Response IL-17, reactive astrocytes accompany with immune infiltration axonal damage MS/EAE. However, regulatory mechanism IL-17-activated inflammation EAE process still remain largely unknown. Here, we elucidated that miR-409-3p miR-1896, as co-upregulated microRNAs activated mice, targeted suppressor...
Fenofibrate, as a lipid-lowering drug, has been reported to have protective effect on the retina independent with plasma lipid levels. This study aimed investigate that ameliorative effects of fenofibrate systemic and retinal inflammation, well gut microbiota dysbiosis in high-fat diet (HFD)-induced mice. C57BL/6J mice were randomly allocated into four groups: standard (SD) group; HFD SD plus (SD_ Fe) (HFD_ group. After successfully establishing models (5 months), indicators associated...
HIV-associated neurocognitive disorders (HANDs) afflict more than half of HIV-1-positive individuals. The transactivator transcription (Tat) produced by HIV virus elicits inflammatory process and is a major neurotoxic mediator that induce neuron damage during HAND pathogenesis. Activated astrocytes are important cells involved in neuroinflammation neuronal damage. Purinergic receptors expressed participate positive feedback loop virus-induced neurotoxicity. Here, we investigated whether...
Dietary fiber is fermented in the lower gastrointestinal tract, potentially impacting microbial ecosystem and thus may improve elements of cognition brain function via gut-brain axis. β-glucans, soluble dietary fiber, have different macrostructures exhibit effects on This study aimed to compare β-glucans from mushroom, curdlan oats bran, representing β-(1,3)/(1,6)-glucan, β-(1,3)-glucan or β-(1,3)/(1,4)-glucan, C57BL/6J mice were fed with either control diet diets supplemented bran for 15...
Previous studies have suggested that glutamate receptor 6 (GluR6) subunit- and JNK-deficient mice can resist kainate-induced epileptic seizure neuronal toxicity (Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinoćn, M., Zheng, T. S., Davis, R. Rakic, P., Flavell, (1997) Nature 389, 865-870; Mulle, C., Seiler, A., Perez-Otano, I., Dickinson-Anson, H., Castillo, P. E., Bureau, Maron, Gage, F. Mann, J. R., Bettler, B., Heinemmann, S. (1998) 392, 601-605). In this study, we show kainate enhance...
Interleukin 9 (IL-9), produced mainly by T helper (Th9) cells, has been recognized as an important regulator in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Astrocytes respond to IL-9 reactive astrocytes always associate with blood-brain barrier damage, immune cell infiltration, spinal injury MS EAE. Several long non-coding RNAs (lncRNAs) aberrant expression have identified the pathogenesis of MS. Here, we examined effects lncRNA Gm13568 (a...
HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage. Pro-inflammatory factors neurotoxins from activated astrocytes by HIV-1 itself its encoded proteins, including the negative factor (Nef), are involved in pathogenesis of HAND. This study was designed to find potential lncRNAs that regulate astrocyte functions inflammation process. We performed microarray analysis primary mouse treated Nef...
Abstract Background Hepatitis B virus (HBV) X protein (HBX) has been reported to be responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular carcinoma (HCC). Vimentin is an EMT-related molecular marker. However, importance of vimentin pathogenesis HCC mediated by HBX not well determined. Methods The expression induced HBX, and role LIM SH3 domain 1 (LASP1) HBX-induced hepatoma cells were examined western blot immunohistochemistry analysis. Both signal...
Abstract Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia‐induced MLK3 and JNK activation neuronal degeneration through the GluR6‐PSD95‐MLK3 signaling module. However, whether KA receptors is involved of p38 MAP kinase during transient brain ischemia/reperfusion (I/R) rat hippocampal CA1 subfield still unknown. In this present study, we first evaluated time‐course phospho‐p38 at various time‐points after 15 min ischemia then observed...
Background/Aims: Multiple sclerosis (MS) is an autoimmune disease in the central nervous system associated with demyelination and axonal injury. Astrocyte activation involved pathogenesis of MS experimental encephalomyelitis (EAE), animal model MS. This study was designed to find potential lncRNAs EAE mice activated astrocytes. Methods: we performed microarray analysis from brain tissues primary mouse astrocytes treated IL-9(50 ng/ml). 12 were validated through real-time PCR. Gene ontology...
Abstract The pro‐inflammatory cytokine interleukin 17 (IL‐17), that is mainly produced by Th17 cells, has been recognized as a key regulator in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Reactive astrocytes stimulated proinflammatory cytokines including IL‐17 are involved blood brain barrier destruction, inflammatory cells infiltration spinal cord injury. However, the role of long non‐coding RNAs (lncRNAs) induced pathogenesis MS EAE remains unknown. Herein,...
Background Sea-level residents experience altitude sickness when they hike or visit altitudes above ~2,500 m due to the hypobaric hypoxia (HH) conditions at such places. HH has been shown drive cardiac inflammation in both ventricles by inducing maladaptive metabolic reprogramming of macrophages, which evokes aggravated proinflammatory responses, promoting myocarditis, fibrotic remodeling, arrhythmias, heart failure, and sudden deaths. The use salidroside preconditioning (AP) before visiting...
We previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357-395 of C X3 motif chemokine ligand 1 (CX3CL1) to induce microglia polarization. More importantly, the peptide Tat-CX3CL1 (comprising CX3CL1) disrupts interaction between and CX3CL1, reducing neurological impairment exerting a protective effect in context acute ischemic stroke. However, mechanism underlying these effects remains unclear. In current study, we found...