A5035047967- Pulmonary Hypertension Research and Treatments
- Adenosine and Purinergic Signaling
- Cytokine Signaling Pathways and Interactions
- Macrophage Migration Inhibitory Factor
- Heme Oxygenase-1 and Carbon Monoxide
- Antibiotic Resistance in Bacteria
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Cardiac Fibrosis and Remodeling
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Renin-Angiotensin System Studies
- Renal function and acid-base balance
- Transplantation: Methods and Outcomes
- Cardiovascular Issues in Pregnancy
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Mycobacterium research and diagnosis
- High Altitude and Hypoxia
- Sepsis Diagnosis and Treatment
- Pregnancy-related medical research
- Heart Failure Treatment and Management
- Organ Transplantation Techniques and Outcomes
Xuzhou Medical College
2021-2025
Stress-induced cardiovascular diseases characterized by inflammation are among the leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol (E2) is known to be cardioprotective via modulation inflammatory mediators during stress. But mechanism unclear. TNFα, a key player inflammation, primarily converted its active form 'A Disintegrin Metalloprotease 17' (ADAM17). We investigated if E2 can regulate ADAM17 Experiments were performed using female FVB wild-type...
Abstract Background During myocardial damage, the sex hormone estrogen and CD73, main enzyme that converts AMP into adenosine, are cardioprotective molecules. However, it is unclear how these two molecules work together to provide cardioprotection. The current study aimed elucidate interaction between CD73 under chronic stress. Methods Ovariectomy SHAM operations were done on FVB wild-type (WT) female mice. Two weeks after operation, mice treated with daily isoproterenol (10 mg/kg/day)...
Abstract Background The human body is highly dependent on adequate oxygenation of the cellular space for physiologic homeostasis mediation. insufficient leads to hypoxia. Hypobaric hypoxia (HH) reduction in oxygen partial pressure and atmospheric during ascent high altitudes. This state induces a maladaptive response. Women how hormones like estrogen influence have not been explored with most research being conducted males. In this study, we investigated effects GPER HIF-1a MIF expression,...
Abstract Background Clinical and experimental studies have shown that the myocardial inflammatory response during pathological events varies between males females. However, cellular molecular mechanisms of these sex differences remain elusive. CD73/adenosine axis has been linked to anti-inflammatory responses, but its sex-specific cardioprotective role is unclear. The present study aimed investigate whether elicits sex-dependent cardioprotection metabolic changes myocarditis induced by...
Background Sea-level residents experience altitude sickness when they hike or visit altitudes above ~2,500 m due to the hypobaric hypoxia (HH) conditions at such places. HH has been shown drive cardiac inflammation in both ventricles by inducing maladaptive metabolic reprogramming of macrophages, which evokes aggravated proinflammatory responses, promoting myocarditis, fibrotic remodeling, arrhythmias, heart failure, and sudden deaths. The use salidroside preconditioning (AP) before visiting...
Pulmonary arterial hypertension (PAH) is characterized by cardiac remodelling. Glutaminolysis plays a crucial role in PAH-induced The metabotropic glutamate receptor 5 (mGluR5) may mediate this process. This study investigated whether or not the blockade of mGluR5 attenuate pathological was induced intraperitoneally injecting male Sprague-Dawley (SD) rats with 60 mg/kg monocrotaline (MCT). 3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) (10 intraperitoneally) used as therapeutic...