A5062239858- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Ion channel regulation and function
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Photosynthetic Processes and Mechanisms
- Head and Neck Cancer Studies
- Vascular Malformations and Hemangiomas
- Cancer Immunotherapy and Biomarkers
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related gene regulation
- Cardiac electrophysiology and arrhythmias
- RNA Research and Splicing
- Lymphoma Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Traditional Chinese Medicine Studies
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- GABA and Rice Research
- Traditional Chinese Medicine Analysis
- Cellular transport and secretion
- Ion Channels and Receptors
- Plant Reproductive Biology
Shenzhen University
2016-2025
Donghua University
2016-2025
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2022-2025
Guangdong Medical College
2025
Second Affiliated Hospital of Nanjing Medical University
2020-2024
Daqing Oilfield General Hospital
2024
Guangzhou Medical University
2018-2023
Harbin Medical University
2022-2023
Cangzhou Central Hospital
2019-2023
Xuzhou Medical College
2013-2023
Cycads represent one of the most ancient lineages living seed plants. Identifying genomic features uniquely shared by cycads and other extant plants, but not non-seed-producing may shed light on origin key innovations, as well early diversification Here, we report 10.5-Gb reference genome Cycas panzhihuaensis, complemented transcriptomes 339 cycad species. Nuclear plastid phylogenomic analyses strongly suggest that Ginkgo form a clade sister to all gymnosperms, in contrast mitochondrial...
As key regulators of gene expression in eukaryotes, small RNAs have been characterized many seed plants, and pathways for their biogenesis, degradation, action defined model angiosperms. However, both themselves RNA are not well other land plants such as lycophytes ferns, preventing a comprehensive evolutionary perspective on plants. Using 25 representatives from major lineages most which lack sequenced genomes, we these We identified homologs DICER-LIKE (DCL), ARGONAUTE (AGO), genes...
Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock. Four databases, PubMed, Cochrane Library, ISI Web Knowledge, Embase, were systematically searched from inception to June 2018 update 2013 edition review two investigators, who independently selected studies, extracted relevant data, study quality. Data subjected trial sequential analysis...
<h3>Background</h3> Little research has been conducted regarding the implications of Sirt1 (a classic III HDAC) in neuropathic pain. The aim this study was to investigate variation expressions spinal and acetyl-histone H3 a rat model chronic constriction injury. <h3>Methods</h3> A pain injury (CCI) established unilateral hind limb Sprague-Dawley rats. <h3>Results</h3> Western blot analysis immunohistochemistry revealed that (silent information regulator) expression decreased, whereas...
GLS-010 (zimberelimab) is a novel, fully human, anti-programmed death-1 monoclonal antibody that shows promising efficacy and safety in advanced solid tumors. This trial aimed to evaluate the of Chinese patients with relapsed or refractory classical Hodgkin lymphoma (r/r-cHL).This phase II, single-arm, open-label, multicenter clinical was conducted at 24 centers China enrolled r/r-cHL after two more lines therapy. The were administered intravenous (240 mg, once every 2 weeks) until...
Antibacterial, anti-inflammatory, and pro-angiogenic properties are prerequisites for dressing materials that accelerate the healing process of infected wounds.
Autonomic stimulation controls heart rate and myocardial excitability may underlie the precipitation of both acquired hereditary arrhythmias. Changes in phosphatidyl inositol bisphosphate (PIP2) concentration results from activation several muscarinic adrenergic receptors. We sought to investigate whether PIP2 changes could alter HERG K + channel activity a manner similar that seen with inward rectifier channels. (10 μmol/L) internally dialyzed increased current amplitude shifted...
Babesiosis is an uncommon but emerging tick-borne disease caused by the genus Babesia. In this case study, we report a of human infection with novel Babesia sp. in China. The patient question had been suffering from repetitive occurrences mild fever unknown origin and fatigue for 10 years. Ring forms, tetrads, one or two dots chromatin trophozoite-like organisms were observed patient's thin blood smears bone marrow smears. Using confocal laser-scanning microscope, it was that serum...
Abstract Plant microRNAs (miRNAs) associate with ARGONAUTE1 (AGO1) to direct post-transcriptional gene silencing and regulate numerous biological processes. Although AGO1 predominantly binds miRNAs in vivo, it also associates endogenous small interfering RNAs (siRNAs). It is unclear whether the miRNA/siRNA balance affects miRNA activities. Here we report that FIERY1 ( FRY1 ), which involved 5′−3′ RNA degradation, regulates abundance function by suppressing biogenesis of ribosomal RNA-derived...
Abstract Long non‐coding RNA (lncRNA) plays an important role in the renal inflammatory response caused by hyperuricaemia. However, underlying molecular mechanisms through which lncRNA is involved endothelial injury induced hyperuricaemia remain unclear. In this study, we investigated regulatory of lncRNA‐HOTAIR high concentration uric acid (HUA)–induced injury. We established mouse model and vitro (UA)–induced human umbilical vein cell (HUVEC) model. HUA‐treated HUVECs mice, observed...
Stress-induced cardiovascular diseases characterized by inflammation are among the leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol (E2) is known to be cardioprotective via modulation inflammatory mediators during stress. But mechanism unclear. TNFα, a key player inflammation, primarily converted its active form 'A Disintegrin Metalloprotease 17' (ADAM17). We investigated if E2 can regulate ADAM17 Experiments were performed using female FVB wild-type...
In plants, serine/arginine-rich splicing factors (SRSFs) play an essential role in pre-mRNA splicing, influencing growth and stress response. The present study investigated the evolution diversification of SR proteins plants by phylogenetic analysis. First, we identified 1650 from 132 plant species. Large-scale analysis divided these into nine subfamilies: SR, RS, SC, SCL, RSZ, RS2Z, SR45, SR45a, a newly discovered RSZ-like subfamily. also suggested that animals originated ancient gene...
Mutations in the cyclic nucleotide binding domain (CNBD) of human ether-a-go-go-related gene (HERG) K+ channel are associated with LQT2, a form hereditary Long QT syndrome (LQTS). Elevation cAMP can modulate HERG channels both by direct and indirect regulation through protein kinase A. To assess physiological significance to HERG, we introduced mutations disrupt domain. Eight mutants including two naturally occurring LQT2 V822M R823W were constructed. Relative capacity was reduced or absent...
T-lymphocyte activation requires sustained Ca2+ signaling dependent upon capacitative entry (CCE). The protein(s) that forms the stores-operated channel (SOCC) responsible for CCE has long been sought but not definitively identified. Members of TRPV family (transient receptor potential superfamily-vanilloid subfamily) genes have proposed to encode SOCCs in non-excitable cells. Here we present evidence a member group, CaT1, is involved generating ICRAC, current necessary T-cell activation....