A5073344681- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Plant and Fungal Species Descriptions
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Plant Diversity and Evolution
- Plant biochemistry and biosynthesis
- Genetic diversity and population structure
- RNA Research and Splicing
- Natural Products and Biological Research
- Immune Response and Inflammation
- Cocoa and Sweet Potato Agronomy
- Yersinia bacterium, plague, ectoparasites research
- Plant tissue culture and regeneration
- Herbal Medicine Research Studies
- Developmental Biology and Gene Regulation
- Vasculitis and related conditions
- Natural product bioactivities and synthesis
- Nephrotoxicity and Medicinal Plants
- Cholinesterase and Neurodegenerative Diseases
- Bioactive Compounds in Plants
- Gut microbiota and health
- Legume Nitrogen Fixing Symbiosis
- Corneal Surgery and Treatments
- Epigenetics and DNA Methylation
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Inner Mongolia Medical University
2024
SinoMaps Press
2024
Henan Cancer Hospital
2021-2024
Zhengzhou University
2021-2024
BGI Group (China)
2019-2023
Landscape Research Group
2023
Authorised Association Consortium
2023
University of Copenhagen
2021
Agricultural Genomics Institute at Shenzhen
2020
MicroRNAs (miRNAs) can regulate nearly all biological processes and their dysregulation is implicated in various complex diseases pathological conditions. Recent years have seen a growing number of functional studies miRNAs using high-throughput experimental technologies, which produced large amount high-quality data regarding miRNA target genes interactions with small molecules, long non-coding RNAs, epigenetic modifiers, disease associations, etc. These rich sets information enabled the...
Cycads represent one of the most ancient lineages living seed plants. Identifying genomic features uniquely shared by cycads and other extant plants, but not non-seed-producing may shed light on origin key innovations, as well early diversification Here, we report 10.5-Gb reference genome Cycas panzhihuaensis, complemented transcriptomes 339 cycad species. Nuclear plastid phylogenomic analyses strongly suggest that Ginkgo form a clade sister to all gymnosperms, in contrast mitochondrial...
Abstract Rosa rugosa , commonly known as rugged rose, is a perennial ornamental shrub. It produces beautiful flowers with mild fragrance and colorful seed pods. Unlike many other cultivated roses, R. adapts to wide range of habitat types harsh environmental conditions such salinity, alkaline, shade, drought, high humidity, frigid temperatures. Here, we produced analyzed high-quality genome sequence for understand its ecology, floral characteristics evolution. PacBio HiFi reads were initially...
Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many these xeno-miRNAs may be involved cross-species interactions and manipulations. To date, hundreds been reported different hosts at various abundance levels. Based on computational predictions, more miRNAs could potentially transferred to human circulation system. There is a clear need for bioinformatics resources tools dedicated xeno-miRNA annotations...
Abstract The low‐grade, chronic inflammation initiated by TLR4‐triggered innate immune responses has a central role on early osteoarthritis. Amurensin H is resveratrol dimer with anti‐inflammatory and anti‐apoptotic effects, while its effects TLR‐4 signals to inhibit osteoarthritis are still unclear. In the present study, treatment amurensin for 2 weeks in monosodium iodoacetate‐induced mice significantly slows down cartilage degeneration using macroscopic evaluation, haematoxylin eosin (HE)...
Amurensin H, a resveratrol dimer derived from Vitis amurensis Rupr, has several biological effects, including anti-inflammatory and antioxidant activities. Studies have found that amurensin H attenuated asthma-like allergic airway inflammation. However, its protective activity on chronic obstructive pulmonary disease (COPD) inflammation is not fully explored. The present study used lipopolysaccharide (LPS)/cigarette smoke-induced mice model an LPS-stimulated THP-1-derived macrophages to...
is commonly known as star fruit because of its peculiar shape, and a rich source minerals vitamins. It also used in traditional medicines countries such India, China, the Philippines, Brazil for treating various ailments, including fever, diarrhea, vomiting, skin disease. Here, we present first draft genome Oxalidaceae family, with an assembled size 470.51 Mb. In total, 24,726 protein-coding genes were identified, 16,490 annotated using well-known databases. The phylogenomic analysis...
Perilla frutescens (L.) Britton is a classic herbal plant used widely against asthma in China. But its mechanism of beneficial effect remains undermined. In the study, antiallergic effects leaf extract (PLE) were investigated, and underlying was also explored. Results showed that PLE treatment significantly attenuated airway inflammation OVA-induced mice, by ameliorating lung pathological changes, inhibiting recruitment inflammatory cells tissues bronchoalveolar lavage fluid (BALF),...
Perilla frutescens (L.) Britt., a classic medicinal plant, has been demonstrated to have anti-inflammatory and anti-allergic effects in asthma. leaves extract (PLE) exerted significant therapeutic effect against allergic asthma inflammation through Syk inhibition. But the active chemical ingredients from PLE are complex unclear, it is difficult fully elucidate its pharmacological mechanisms.A method was established for rapid screening characterization of that targeted Syk, with which three...
The Hong Kong Jellyfish Project is a citizen science initiative started in early 2021 to enhance our understanding of jellyfish Kong. Here, we present dataset sightings collected by scientists from through 2023 within local waters. Citizen submitted photographs and other data (time, date, location) using website, iNaturalist project, social media. Sightings were validated references the literature. A total 1,020 usable observations are included this dataset, showing occurrence distribution...
RNA extraction of plant tissues (in our case Bauhinia leaves) using a pBIOZOL/CTAB lysis buffer
Pax6 is a pivotal transcription factor that plays role during early eye morphogenesis, but its expression and function in eyelid development remain unknown. In this study, the patterns of mRNA protein were examined developing mouse at embryonic days 14.5, 15.5, 16.5. The was determined by comparing it to eyes-open-at-birth mutant mouse. normally eyelid, Pax6(5a) levels low E14.5, increased E15.5, then declined E16.5, accompanied change Pax6/Pax6(5a) ratio. mainly located mesenchyme...
Nyssa yunnanensis is a deciduous tree species in the family Nyssaceae within order Cornales. As only eight individual trees and two populations have been recorded China’s Yunnan province, this has listed among national Class I protection since 1999 also 120 PSESP (Plant Species with Extremely Small Populations) Implementation Plan of Rescuing Conserving Plant Populations (PSESP) (2011-2-15). Here, we present draft genome assembly N. yunnanensis. Using 10X Genomics linked-reads sequencing...
Osteonecrosis of the femoral head is a common orthopedic disease. Based on years clinical experience and significant imaging data, this study aimed to elucidate new type it, help improve prognosis in young adults provide basis for hip preservation treatment.From January 2014 December 2016, total 211 patients undergoing surgery necrosis at our hospital were enrolled study. Coronal plane classification cross-sectional area analysis performed by nuclear magnetic resonance (computed tomography...
Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) underlying mechanism not been investigated. In this study, we explored the therapeutic of RosA COPD airway inflammation alveolar epithelial apoptosis
Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many these xeno-miRNAs may be involved cross-species interactions by targeting mRNAs. To date, hundreds been reported different hosts at various abundance levels. Many more miRNAs could potentially transferred to human circulation system based on computational predictions. There is a clear need for bioinformatics resources and tools dedicated xeno-miRNA...