Gram-negative bacteria can naturally produce nanosized spherical outer membrane vesicles (OMVs) with a lipid bilayer membrane, possessing immunostimulatory capabilities to be potentially applied in tumor therapy. However, the systemic toxicity induced by pathogen-associated molecular patterns (PAMPs) of OMVs is main obstacle for their clinical translation. Herein, melanin-loaded were produced genetic engineering strategy and further coated calcium phosphate (CaP) reduce enhance treatment...

Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted the antioxidant capacity of tumor. Previous solutions focused on strengthening nanodrugs with ability to increase ROS production weaken cells. Conversely, we here develop a mild nanodrug negligible side effects. Specifically, Au@Pt nanozyme decorated bacterial surface (Bac-Au@Pt) reported achieve precise CDT. Due tumor targeting bacteria and...

Abstract The miniaturization of gold nanorods exhibits a bright prospect for intravital photoacoustic imaging (PAI) and the hollow structure possesses better plasmonic property. Herein, miniature (M‐AuHNRs) (≈46 nm in length) possessing strong absorbance second near‐infrared (NIR‐II) window (1000–1350 nm) are developed, which considered as most suitable range PAI. as‐prepared M‐AuHNRs exhibit 3.5 times stronger signal intensity than large Au (≈105 at 0.2 optical density under 1064 laser...

This study explored the global cyberspace security issues, with purpose of breaking stereotype people’s cognition problems, which reflects relationship between interdependence and association. Based on Apriori algorithm in association rules, a total 181 strong rules were mined from 40 target websites 56,096 web pages associated security. Moreover, this analyzed support, confidence, promotion, leverage, reliability to achieve comprehensive coverage data. A 15,661 sites mentioned...

The strategy that combines photodynamic therapy (PDT) and photothermal (PTT) is widely used to achieve strong antitumor efficiency.Since light in the NIR-II window possesses ideal penetration ability, developing PTT triggered photosensitizer release for combined PDT very promising nanomedicine.Methods: We develop a novel nanocarrier (termed AuHNRs-DTPP) by conjugating contained chimeric peptide (DTPP) Au hollow nanorods (AuHNRs).AuHNRs was obtained Te-templated method with assistance of...

Guizhou is a mountainous region that faces numerous engineering challenges during the mining of thick inclined ore bodies, including complex geological conditions, limited monitoring systems, and insufficient on-site monitoring. Developing intelligent methods for predicting surface movement deformation in areas under such conditions critical preventing ecological damage, safeguarding lives property, ensuring safe operations. This study focuses on subsequent filling bodies as context. Using...

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous characterized by persistent airflow limitation but still lacking effective treatments. Perilla frutescens (L.) Britt., an important traditional medicinal plant with excellent antioxidant anti-inflammatory properties, widely used for the treatment of respiratory in China. However, its protective activity mechanism against COPD airway inflammation have not been fully studied. Here, effects PLE were investigated,...

Extracellular vesicles (EVs) have emerged as potential tools for tumor-target therapy accompanied with activating anticancer immune responses by serving an integrated platform, but usually suffered from the limited cross presentation of tumor-associated antigen dendritic cells (DCs). Here, a straightforward engineering strategy to construct heat shock proteins 70 (HSP70) highly expressed EVs incapsulated Te nanoparticles (Te@EVsHSP70 ) tumor photothermal triggering improved immunotherapy is...

Environmental exposures during pregnancy have been associated with adverse obstetric outcomes. However, limited and inconsistent evidence exists regarding the association between air temperature exposure risk of preeclampsia (PE). This study aimed to evaluate correlation ambient PE risk, as well identify specific time window that increases risk. A population-based cohort was conducted from January 2012 April 2022 in Guangzhou, China. Pregnant women were recruited early followed until...

Perilla frutescens (L.) Britton is a classic herbal plant used widely against asthma in China. But its mechanism of beneficial effect remains undermined. In the study, antiallergic effects leaf extract (PLE) were investigated, and underlying was also explored. Results showed that PLE treatment significantly attenuated airway inflammation OVA-induced mice, by ameliorating lung pathological changes, inhibiting recruitment inflammatory cells tissues bronchoalveolar lavage fluid (BALF),...

Perilla frutescens (L.) Britt., a classic medicinal plant, has been demonstrated to have anti-inflammatory and anti-allergic effects in asthma. leaves extract (PLE) exerted significant therapeutic effect against allergic asthma inflammation through Syk inhibition. But the active chemical ingredients from PLE are complex unclear, it is difficult fully elucidate its pharmacological mechanisms.A method was established for rapid screening characterization of that targeted Syk, with which three...

Computer-controlled subaperture polishing technology is limited by its propensity to introduce midspatial frequency (MSF) error (ripple error), which significantly inhibits the performance improvement of optical systems. The pseudo-random path an important method for suppressing MSF error. However, a that ensures both smoothness and planning efficiency difficult generate. This paper proposes novel, best our knowledge, employing reconstructive points algorithm efficiently achieves full...

Bacteria show promise for use in the field of combination cancer therapy because their abilities to accumulate tumors and roles as natural immunologic adjuvants. However, huge size bacteria decreases chances being delivered into tumor cells. Moreover, toxins may cause systemic toxicity living organisms. Here, we proposed a method situ synthesize Au nanoparticles on surface Escherichia coli (E. coli), followed by sonication acquire loaded membrane nanosheets (AuMNs) photothermal therapy....

Asthma-chronic obstructive pulmonary (COPD) overlap (ACO) coexists with asthma and COPD syndrome characteristics, more frequent exacerbations, heavier disease burden, higher medical utilization, even lower quality of life. However, the ACO standard medications supported by evidence-based medicine have not yet appeared.By using an mouse model established previously LPS-stimulated RAW264.7 macrophages in vitro, a potential therapeutic candidate, EAPP-2, was screened from derivatives...

Optical smoothing is a very effective method to restrict mid-to-high spatial frequency errors generated by computer-controlled sub-aperture polishing technologies. According Preston's equation, pressure distribution the key factor in describing effect of tool. Although classic bridging model can solve during process, it only suitable for tool that consists rigid base, compliant interlayer, thin metal plate, and pitch layer. In this paper, mathematical applicable any multi-layer proposed,...

Three-dimensional numerical simulations are carried out to investigate the temperature field in contact zone due thermal loading of workpiece surface grinding. This technique considers that thermophysical properties material non-linear according temperature, between wheel and is assumed as an arc surface, heat flux entering proportional local undeformed chip thickness. A good agreement found simulated results experimental observations. The high grinding leads expansion material, which causes...

Asthma–chronic obstructive pulmonary disease (COPD) overlap (ACO) is a severe clinical syndrome characterized to describe patients with both asthma and COPD characteristics, which has posed serious threat patients’ quality of life safety. However, there are many difficulties uncertainties in its diagnosis treatment clinic; especially, animal model not been fully thoroughly established, the evaluation therapeutic drugs still infancy. Here, we used ovalbumin (OVA), lipopolysaccharide (LPS),...

In order to improve the processing ability of fuzzy information in air combat situation assessment, this paper improves cloud model theory and establishes an improved fighter assessment model. Firstly, factors are reduced weights assigned. Then, is used generate diagram situation. Compared with evaluation diagram, evaluated. Finally, reliability verified through example calculation.

The purpose of situation assessment in regional air defense combat is to quickly fuse data as well provide commanders with timely support for decision making. We propose a new framework combat, which plays very concrete role real and follows the process. proposed involves three aspects: capability region; prediction an enemy’s invasion route; generation interception plan. A Bayesian network used evaluate infer region. In network, calculation input evidence based on threat models from radar,...

Many mines in Guizhou Province are urgent need of renovation to ensure harmonious operation and prolong their lifespan. The key successful lies the prudent selection appropriate mining technologies. Therefore, a comprehensive investigation was conducted on steep coal Province, evaluation framework established. Spearman correlation analysis performed various factors, selecting geological conditions working face parameters with high as input variables methods output variables. optimal values...

Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) underlying mechanism not been investigated. In this study, we explored the therapeutic of RosA COPD airway inflammation alveolar epithelial apoptosis