A5002663710- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Kruppel-like factors research
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- Advanced Computational Techniques and Applications
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- interferon and immune responses
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
University of Shanghai for Science and Technology
2025
Ningxia Medical University
2024
Zhongnan Hospital of Wuhan University
2013-2023
Wuhan University
2012-2023
First Affiliated Hospital of Guangzhou Medical University
2023
State Key Laboratory of Respiratory Disease
2019-2023
Guangzhou Medical University
2023
As availability of precision therapies expands, a well-validated circulating cell-free DNA (cfDNA)-based comprehensive genomic profiling assay has the potential to provide considerable value as complement tissue-based testing ensure potentially life-extending are administered patients most likely benefit. Additional data supporting clinical validity cfDNA-based is necessary inform optimal use these assays in clinic. The FoundationOne®Liquid CDx pan-cancer that was recently approved by FDA....
Hyperglycaemia is associated with an elevated risk of mortality in community-acquired pneumonia, stroke, acute myocardial infarction, trauma and surgery, among other conditions. In this study, we examined the relationship between fasting blood glucose (FBG) 28-day coronavirus disease 2019 (COVID-19) patients not previously diagnosed as having diabetes.We conducted a retrospective study involving all consecutive COVID-19 definitive outcome FBG measurement at admission from 24 January 2020 to...
Abstract Background Circular RNAs (circRNAs) play important regulatory roles in the development of various cancers. However, biological functions and underlying molecular mechanism circRNAs gastric cancer (GC) remain obscure. Methods Differentially expressed were identified by RNA sequencing. The circSHKBP1 GC investigated a series vitro vivo experiments. expression was evaluated using quantitative real-time PCR situ hybridization, demonstrated western blot, pulldown, immunoprecipitation,...
Purpose: Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the overall biological roles and clinical significance most lncRNAs gastric carcinogenesis are not fully understood. We investigated significance, function, mechanism LINC01234 cancer.Experimental Design: First, we analyzed alterations cancerous noncancerous tissues through an analysis sequencing data obtained from The Cancer Genome Atlas. Next, evaluated...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide, and biology this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety cancers, including HCC. Taurine Up-regulated Gene 1 (TUG1), 7.1-kb lncRNA, recruiting binding polycomb repressive complex 2 (PRC2), disregulated non-small cell lung (NSCLC) esophageal squamous (ESCC). However, its clinical significance potential...
Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes, including cell proliferation, differentiation and cancer cells metastasis. Accumulating evidence has revealed that aberrant lncRNA expression plays important roles in carcinogenesis tumor progression. However, the pattern biological function lncRNAs non-small-cell lung (NSCLC) remain largely unknown. In this study, we performed comprehensive analysis human NSCLC samples by using...
Abstract Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated a variety cancers. Long non-coding RNAs (lncRNAs) are also reported exert important effect on tumorigenesis. aberrantly expressed gastric cancer (GC), biology functions GC controversial. The biological characteristics correlation between lncRNAs remain found. In this study, integrated analysis revealed expression was significantly...
Abstract Background Cisplatin resistance is the main cause of poor clinical prognosis in patients with gastric cancer (GC). Yet, exact mechanism underlying cisplatin remains unclear. Recent studies have suggested that exocrine miRNAs found tumor microenvironment participate metastasis and drug resistance. Methods Exosomes isolated from BGC823 BGC823/DDP culture medium were characterized by transmission electron microscopy differential ultracentrifugation, miRNA expression profiles cells...
Abstract Background N6‐methyladenosine (m 6 A) RNA modification is known as a common epigenetic regulation form in eukaryotic cells. Emerging studies show that m A noncoding RNAs makes difference, and the aberrant expression of A‐associated enzymes may cause diseases. The demethylase alkB homologue 5 (ALKBH5) plays diverse roles different cancers, but its role during gastric cancer (GC) progression not well known. Methods quantitative real‐time polymerase chain reaction, immunohistochemistry...
Long noncoding RNAs (lncRNAs) play a vital role in tumorigenesis. Until now, the value of circulating lncRNAs diagnosis breast cancer (BC) has remained unknown. Here, we have explored clinical significance GAS5 and H19 BC patients. Total RNA plasma was extracted from 90 preoperative patients, 39 postoperative 76 healthy controls. The expression levels were measured by quantitative real-time PCR. potential associations between GAS5, levels, patients' characteristics analyzed. No significant...
Abstract Cartilage‐derived mesenchymal stem cells (MSCs) have been isolated with different methods. In this study lateral and medial femoral condyles were respectively collected from patients late‐stage osteoarthritis during the total knee arthroplasty. After digestion of cartilage tissues type II collagenase analysis by fluorescence‐activated cell sorting (FACS) CD146, a chondroprogenitor sub‐population purified. The expression other MSC‐associated markers in CD146 + chondroprogenitors was...
Non-small cell lung cancer (NSCLC) is the most common type of cancer, and multiple evidence has confirmed that C5a production elevated in NSCLC microenvironment. Although proliferation induced by been reported, involved mechanism not elucidated. In this study, we examined proliferation-related genes (i.e., KLF5, GCN5, GDF15) receptor (C5aR) expression tumor tissues as well concentration plasma patients, then determined roles GDF15 C5a-triggered related both vitro vivo. Our results found...
N6-Methyladenine (m6A) is the most abundant internal modification on mammalian mRNA. Very recently, m6A has been reported as a potentially important 'epigenetic' mark in eukaryotes. Until now, site-specific detection of technically very challenging. Here, we first reveal that significantly hinders DNA- and RNA-directed DNA synthesis. Systematic investigations 5'-triphosphates variety 5-substituted 2'-deoxyuridine analogs primer extension have performed. In current study, quantitative...
With the high incidence of obesity around globe, potential role bile acid metabolism and gut microbiota in modulating aroused great enthusiasm. Here we studied anti-obesity effect dihydromyricetin (DHM), main biologically active component Ampelopsis grossedentata, which was applied for thousands years form tea beverages. A 12-week treatment DHM significantly reduced body weight gain ob/ob mice. Meanwhile, serum parameters that are closely associated with obesity, including levels total...