A5046005596- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Energetic Materials and Combustion
- Thermal and Kinetic Analysis
- Crystallography and molecular interactions
- Rocket and propulsion systems research
- Structural Load-Bearing Analysis
- Herpesvirus Infections and Treatments
- Structural Engineering and Vibration Analysis
- Chemical Reactions and Mechanisms
- Combustion and Detonation Processes
- Hydrology and Watershed Management Studies
- Machine Learning in Materials Science
- Structural Analysis and Optimization
- interferon and immune responses
- High-pressure geophysics and materials
- Boron and Carbon Nanomaterials Research
- Hydrology and Sediment Transport Processes
- Chemical Thermodynamics and Molecular Structure
- Computational Drug Discovery Methods
- Fire effects on concrete materials
- Flood Risk Assessment and Management
- NF-κB Signaling Pathways
- Fullerene Chemistry and Applications
- Toxin Mechanisms and Immunotoxins
Northwestern Polytechnical University
2024-2025
China Academy of Engineering Physics
2018-2024
Huazhong University of Science and Technology
2019-2024
Union Hospital
2019-2024
University of Chinese Academy of Sciences
2023-2024
Union Hospital
2021-2024
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Intelligent Health (United Kingdom)
2022
Shanghai Jiao Tong University
2022
Hyperglycaemia is associated with an elevated risk of mortality in community-acquired pneumonia, stroke, acute myocardial infarction, trauma and surgery, among other conditions. In this study, we examined the relationship between fasting blood glucose (FBG) 28-day coronavirus disease 2019 (COVID-19) patients not previously diagnosed as having diabetes.We conducted a retrospective study involving all consecutive COVID-19 definitive outcome FBG measurement at admission from 24 January 2020 to...
Finding new high-energy-density materials with desired properties has been intensely-pursued in recent decades. However, the contradictory relationship between high energy and low mechanical sensitivity makes innovation of insensitive an enormous challenge. Here, we show how a genome approach can be used to accelerate discovery high-energy explosives by identification "genetic" features, rapid molecular design, screening, as well experimental synthesis target molecule,...
A zwitterionic fused-ring based energetic material (ZDPT) was prepared. ZDPT has excellent thermal stability ( T d = 347 °C ) and great detonation velocity D 8390 m s −1 ), which endow with potential as a heat-resistant material.
Herpes simplex virus type 1 (HSV-1) plasmid vectors have promise for genetic intervention in the brain, but several problems caused by helper compromised their utility. To develop a virus-free packaging system these vectors, DNA cleavage/packaging signals were deleted from set of cosmids that represents HSV-1 genome. Following cotransfection into cells, this modified cosmid supported replication and vector DNA. However, absence signals, genome was not packaged, consequently stocks free...
Abstract The experimental detection and synthesis of pentazole (HN 5 ) its anion (cyclo‐N − have been actively pursued for the past hundred years. an aesthetic three‐dimensional metal–pentazolate framework (denoted as MPF‐1) is presented. It consists sodium ions cyclo‐N anions in which isolated are preternaturally stabilized this inorganic open featuring two types nanocages (Na 20 N 60 Na 24 through strong metal coordination bonds. compound MPF‐1 indefinitely stable at room temperature...
A versatile host–guest driven explosive-oxidant inclusion strategy was proposed to develop advanced high-energy-density materials (HEDMs) with high detonation performances, low mechanical sensitivities and excellent combustion properties.
The creation of high-performance energetic materials with good mechanical sensitivities has been a great challenge over the past decades, since such have huge amounts energy and are thus essentially unstable. Here, we report on promising fused-ring material an unusual two-dimensional (2D) structure, 4-nitro-7-azido-pyrazol-[3,4-d]-1,2,3-triazine-2-oxide (NAPTO), whose unique 2D structure confirmed by single-crystal X-ray diffraction. Experimental studies show that this novel compound...
Predicting chemical properties is one of the most important applications machine learning. In recent years, prediction energetic materials using learning has been receiving more attention. This review summarized advances in predicting compounds' (e.g., density, detonation velocity, enthalpy formation, sensitivity, heat explosion, and decomposition temperature) Moreover, it presented general steps for applying to practical from aspects data, molecular representation, algorithms, accuracy....
Vectors based on herpes simplex virus type 1 (HSV-1) show promise for gene transfer into mammalian cells because of their wide host range, efficient infection and ability to deliver genes nondividing cells. Defective HSV-1 vectors, or amplicons, are plasmid vectors which unable propagate own but contain specific sequences that, in the presence helper virus, support DNA replication subsequent packaging particles. We compared three replication-incompetent mutants (KOS strain 5dll.2, 17 D30EBA,...
A series of fused-ring energetic materials, i.e., 3,6-dinitro-1,4-di(1H-tetrazol-5-yl)-pyrazolo[4,3-c]pyrazole (DNTPP, compound 2) and its ionic derivatives (compounds 3–8), were designed synthesized in this study. The molecular structures compounds 2, 3, 6, 7·2H2O, 8 confirmed using single-crystal X-ray diffraction. Their physicochemical properties, such as density, thermal stability, heat formation, sensitivity, detonation properties (e.g., velocity pressure), also evaluated. results...
A novel hydrogen peroxide adduct of ammonium cyclopentazolate was successfully synthesized and shows promising application potential as a green propellant component.
Potential energetic melt-castable materials were screened out by machine-learning assisted high-throughput virtual screening from a generated chemical space, then eight compounds synthesized and characterized.
The development of energetic materials with high energy and low sensitivity has attracted immense interests due to their widespread applications in aerospace technology national defense. In this work, a promising self-assembly strategy was developed prepare three high-energy (1–3) through the introduction oxidant molecules into crystal voids parent materials. structures these new were comprehensively examined by infrared spectroscopy, nuclear magnetic resonance (NMR) single-crystal X-ray...
Finding energetic materials with tailored properties is always a significant challenge due to low research efficiency in trial and error. Herein, methodology combining domain knowledge, machine learning algorithm, experiments presented for accelerating the discovery of novel materials. A high-throughput virtual screening (HTVS) system integrating on-demand molecular generation models covering prediction crystal packing mode scoring established. With proposed HTVS system, candidate molecules...
Two high-performance heat-resistant energetic materials were developed via a synergistic strategy of designing hydrogen bonding networks and expanding the π-conjugation system.
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. Some reports show that berberine exhibits anti-inflammatory, antitumor, and antiviral properties by modulating multiple cellular signaling pathways, including p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase. In present study, we investigated effect against herpes simplex virus (HSV) infection. Current antiherpes medicines such as acyclovir can lessen recurring activation when...
PurposeThe role of serum tumor markers (STMs) in the modern management epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations lung cancer remains poorly described. In this study, we investigated whether STMs could be a valuable noninvasive tool to predict EGFR ALK positivity non-small-cell (NSCLC) patients.Experimental designWe retrospectively reviewed included 1089 NSCLC patients who underwent or mutation testing measurement prior treatment. The differences...
A new design strategy for zwitterionic energetic materials was developed, and two gem-dinitromethyl functionalized 5-amino-1,3,4-oxadiazolate inner salts were synthesized characterized. Compared with common salt analogues, both compounds exhibited higher densities, better detonation performances, comparable mechanical sensitivities. This may stimulate the development of additional materials.
A series of asymmetric oxadiazole nitramine compounds were designed and synthesized, a comparative study detonation, sensitivity, thermal properties three isomers is made.
For an energetic material with a definite composition, the substituent position is most crucial factor to influence its physicochemical properties. Thus, it becoming increasingly important understand impact of positional isomerism on multidimensional properties differences. Herein, we reported two new potential melt-castable molecules, pair isomers (4-MMDNP and 5-MMDNP). These explosives exhibit obviously different properties, including densities (Δρ = 0.03 g cm–3), melting point (ΔTm 47.2...