A5100379821- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Head and Neck Cancer Studies
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Alcohol Consumption and Health Effects
- Organ Transplantation Techniques and Outcomes
- COVID-19 and Mental Health
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Periodontal Regeneration and Treatments
- Bone Metabolism and Diseases
- Substance Abuse Treatment and Outcomes
- Dental Implant Techniques and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bone health and treatments
- Long-Term Effects of COVID-19
- Estrogen and related hormone effects
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- SARS-CoV-2 and COVID-19 Research
Nantong University
2019-2025
Yancheng First People's Hospital
2019-2025
Xuzhou Medical College
2024-2025
Jiangsu University
2025
Shaoxing City Women and Children Hospital
2024
Qingdao University
2023
China People's Public Security University
2023
Tianjin Medical University Cancer Institute and Hospital
2023
National Clinical Research
2023
Tianjin Stomatological Hospital
2023
Abstract Background Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors 14-day and 28-day mortality develop model for predicting survival probability among adult hospitalized patients with COVID-19. Methods In this multicenter, retrospective, cohort study, we examined 828 confirmed COVID-19 in Wuhan Union Hospital Central between January 12 February 9, 2020. Among patients, 516 186 consecutive admitted were enrolled...
Elucidation of the molecular mechanisms involved in pathogenesis coronavirus disease 2019 (COVID-19) may help to discover therapeutic targets.To determine metabolomic profile circulating plasma from COVID-19 survivors with pulmonary sequelae 3 months after discharge, a random, outcome-stratified case-control sample was analyzed. We enrolled 103 recovered patients as well 27 healthy donors, and performed function tests, computerized tomography (CT) scans, laboratory examinations, liquid...
// Xiang Qi 1 , Kevin Tak Pan Ng Zhou Lian 2 Xiao Bing Liu Chang Xian Li Wei Geng Chun Ling Yuen Ma Wai Ho Yeung Wen Tu 3 Sheung Tat Fan Chung Mau Lo Kwan Man Department of Surgery, Centre for Cancer Research, The University Hong Kong, Pokfulam, China. Medicine, Paediatrics & Adolescent Correspondence to: Man, e-mail: kwanman@hku.hk Keywords: GPx3, HCC, hiPSC-MSCs, Tumor suppressor gene, Prognosis Received: July 24, 2014 Accepted: September 30, Published: October 11, ABSTRACT Aims: We aimed...
Immune checkpoint inhibitors (ICIs) have been extensively utilized in the treatment of esophageal squamous cell carcinoma (ESCC); however, patient responses to these therapies exhibit significant variability. This study aimed investigate prognostic value Geriatric Nutritional Risk Index (GNRI) patients with ESCC undergoing immunotherapy. A retrospective was conducted on 677 metastatic/recurrent or unresectable who received Kaplan-Meier analysis and Log-rank test compared survival differences...
Metabolic reprogramming plays a pivotal role in the development and progression of tumors. Tumor cells rely on glycolysis as their primary energy production pathway effectively utilize biomolecules generated by pentose phosphate (PPP) for efficient biosynthesis. However, 6-phosphogluconate dehydrogenase (6PGD), crucial enzyme PPP, remains unexplored esophageal squamous cell carcinoma (ESCC). In this study, we observed significant upregulation 6PGD expression ESCC tissues, which correlated...
Abstract Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets carcinoma, chemoresistant carcinoma cell lines were established. By comparing global gene expression profiles between chemosensitive lines, eight genes identified to be significantly associated commonly augmented chemoresistance cells. One upregulated candidate named transmembrane protein...
Background and Aims: Down-regulation of GPx3 accelerated hepatic senescence, which further caused overwhelming inflammation severe liver graft injury.MSCs derived from human induced pluripotent stem cells (hiPSC-MSCs) have been developed as more efficient delivery vehicle with the property injury tropism.Here, we aimed to explore suppressive role in IR using novel system hiPSC-MSCs. Methods:The mice model partial hepatectomy was established.The engineered hiPSC-MSCs delivering...
Background and Aims: Our previous study showed that small-for-size liver graft may provide favorable micro-environment for tumor growth.GPx3, an anti-oxidant, not only attenuates oxidative stress, but also suppresses growth in our recent study.Here, we aimed to characterize the clinical significance explore functional role of GPx3 HCC recurrence after transplantation.Methods: To association between expression invasiveness, a rat orthotopic transplantation model with development was...
Aims We previously demonstrated Proline rich tyrosine kinase 2 (Pyk2) plays important roles in regulating tumor progression, migration and invasion hepatocellular carcinoma (HCC). In this study, we aimed to examine the role of proline on cisplatin resistance HCC explore its underlying molecular mechanism. Methodology/Principal Findings Stable transfectants either overexpressing or suppressing Pyk2 were established different cell lines. MTT, colony formation Annexin-V assays employed their...
Wei Geng1,3, Chung-Mau Lo1,2, Kevin T.P. Ng1, Chang-Chun Ling1, Xiang Qi1, Chang-Xian Li1, Yuan Zhai4, Xiao-Bing Liu1, Yuen-Yuen Ma1, Kwan Man1,2 1Department of Surgery, The University Hong Kong, China 2Collaborative Innovation Center for Diagnosis and Treatment Infectious Diseases, Hangzhou, 3Department Transplantation Hepatic Renji Hospital, School Medicine, Shanghai Jiaotong University, Shanghai, 4Department David Geffen California at Los Angeles, CA, USA Correspondence to: Man, e-mail:...
Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond radiotherapy due intrinsic radioresistance cells. This study was designed investigate effects and potential mechanism radiosensitization associated with DNA‑dependent protein kinase catalytic subunit (DNA‑PKcs) inhibitor human GC cell lines vitro. Among six (SGC7901,...
Esophageal cancer patients are at a high risk of malnutrition. Both the disease itself and chemoradiotherapy will lead to deterioration nutritional status. The development oncology promotes application enteral nutrition in tumor patients. Through support, prognosis is improved incidence adverse reactions reduced, especially those with head neck or esophageal cancer. This review summarizes support undergoing recent years, including selection assessment tools, causes consequences malnutrition...
Background: A massive outbreak of Coronavirus disease 2019 (COVID-19) hit Wuhan City, Hubei Province, China and has become a public health emergency global concern. In this study, we aimed to describe the clinical characteristics short-term outcomes explored mortality-related risk factors. Methods: retrospective, single-centre, case-control examined 315 consecutive patients hospitalized in Union Hospital West Area from January 12, 2020 February 3, 2020, for suspected or confirmed COVID-19....
To investigate the predictive effect of combined markers haemoglobin and prognostic nutritional index (PNI) on long-term survival patients undergoing postoperative radiotherapy for esophageal squamous cell carcinoma (ESCC).A total 238 were included in this retrospective analysis. PNI was calculated as serum albumin level (g/L) + 5 × absolute lymphocyte count, cut-off values by receiver operating characteristic (ROC) curve Then, we PNI, named H-PNI score, a predictor tumour prognosis. The...
Gene associated with retinoid‑interferon (IFN)‑induced mortality 19 (GRIM‑19), a novel IFN‑β/retinoic acid‑inducible gene product, has been identified as potential tumor suppressor, which is the inhibition of growth. GRIM‑19 demonstrated to be downregulated in ovarian tissue patients breast cancer, however, its role cancer remains fully elucidated. In present study, recombinant eukaryotic expression plasmid carrying was constructed and then transfected into MCF7 human cell line examine...
Aims: To investigate the prognostic value of hemoglobin combined with geriatric nutritional risk index (GNRI) scores in patients undergoing postoperative radiotherapy for esophageal squamous cell carcinoma (ESCC). Patients & methods: who underwent esophagectomy and were included this retrospective study. Their preoperative GNRI collected to establish hemoglobin-GNRI (H-GNRI) scores, their association OS was evaluated. Results: high H-GNRI had better prognosis than those low (p < 0.001)....
By microwave wet digestion procedure with HNO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /H xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O to prepare samples, the mineral elements in Crocus sativus L. were completely analyzed by inductively coupled plasma optical emission spectrometer (ICP-OES). The results showed there 17 L., which Na, K, S, Mg, P, Si, Ca, Fe, Al, Ti, Zn, Mn, B, Sr, Cu, Ba and Cr. RSD of determining result...
非典型小叶状宫颈腺体增生作为非人乳头状瘤病毒（HPV）依赖型宫颈原位腺癌的一种组织类型，可能源于小叶状宫颈腺体增生和简单型胃型腺体化生。本文报道1例非HPV依赖型宫颈原位腺癌（非典型小叶状宫颈腺体增生），临床表现为长期阴道排液，HPV阴性。宫颈脱落细胞学检查镜下见富腺细胞，排列拥挤、重叠，胞质丰富透亮、部分稠厚、个别略呈淡黄色，核略大、可见嗜酸性小核仁，判读为非典型腺细胞，无具体指定，其细胞块及宫颈管搔刮中黏液腺体胞质同步呈现免疫组织化学MUC6弥漫强阳性并特殊染色阿辛蓝-过碘酸雪夫（AB-PAS）染色玫红显色模式，提示存在胃型分化腺体。全子宫标本中宫颈管近内口距表层4.5 mm间质见非典型小叶状宫颈腺体增生。免疫表型：Ki-67阳性指数约5%，DPC4弥漫强阳性，p53野生型模式，PAX2小叶状腺体阳性、非典型腺体弱阳性，p16阴性；MUC6、AB-PAS与细胞块表达模式一致。回顾其诊疗经过并复习相关文献，有助于宫颈胃型腺癌及癌前病变的筛查与诊断。.
To investigate the prognostic value of inflammatory markers in esophageal squamous cell carcinoma (ESCC) patients treated with immune checkpoint inhibitors (ICIs).
α-Hederin is a monosaccharide pentacyclic triterpene saponin compound derived from the Chinese herb, Pulsatilla. It has garnered considerable attention for its anti-tumor, anti-inflammatory, and spasmolytic pharmacological activities. Given rising incidence of cancer pronounced adverse reactions associated with chemotherapy drugs-which profoundly impact quality life patients-there an immediate need safe effective antitumor agents. Traditional drugs their anticancer effects have become focal...