A5101531129- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Physics of Superconductivity and Magnetism
- DNA Repair Mechanisms
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Neurological Disease Mechanisms and Treatments
- Laser-induced spectroscopy and plasma
- Cancer-related Molecular Pathways
- Laser-Plasma Interactions and Diagnostics
- ZnO doping and properties
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
- Fibroblast Growth Factor Research
- Extracellular vesicles in disease
- Intensive Care Unit Cognitive Disorders
- Laser-Matter Interactions and Applications
- COVID-19 and Mental Health
- MicroRNA in disease regulation
- BRCA gene mutations in cancer
- Catalytic Processes in Materials Science
Jianghan University
2019-2025
Peking University
2014-2025
Institute of Biomedical Science
2025
Nanjing University of Chinese Medicine
2025
Wenzhou University
2022-2025
Molecular Oncology (United States)
2023-2025
Inner Mongolia Agricultural University
2004-2025
Anhui University
2025
University of California, San Diego
2025
Yancheng First People's Hospital
2025
This study investigated the application of a therapeutic tumor cell–derived microparticle-based nanodelivery platform in malignant pleural effusion.
Hepatocellular carcinoma (HCC), one of the leading causes cancer-related death, develops from premalignant lesions in chronically damaged livers. Although it is well established that FGF19 acts through receptor complex FGFR4-β-Klotho (KLB) to regulate bile acid metabolism, also implicated development HCC. In humans, amplified HCC and its expression induced liver under cholestatic cirrhotic conditions. mice, ectopic overexpression drives a process requires FGFR4. this study, we describe an...
Nontumorigenic FGF19 variants represent an effective approach for the prevention and treatment of cholestatic liver diseases.
Abstract Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is second leading cause cancer mortality worldwide. Fibroblast Growth Factor 19 ( FGF19 ) one most frequently amplified genes in HCC patients. Moreover, mice expressing an transgene have been shown to develop HCC. However, downstream signalling pathways that mediate -dependent tumorigenesis remain be deciphered. Here we show triggers previously unsuspected, non-cell-autonomous program activate STAT3 hepatocytes...
Bile acid nuclear receptor farnesoid X (FXR) is a key molecular mediator of many metabolic processes, including the regulation bile acid, lipid and glucose homeostasis. A significant component FXR-mediated events essential to its biological activity attributed induction enteric endocrine hormone fibroblast growth factor (FGF)19 or rodent ortholog, FGF15. In this report, we compared properties human FGF19 murine FGF15 in hepatocarcinogenesis metabolism various mouse models...
We report on the experimental studies of laser driven ion acceleration from a double-layer target where near-critical density with few-micron thickness is coated in front nanometer-thin diamondlike carbon foil. A significant enhancement proton maximum energies 12 to $\ensuremath{\sim}30\text{ }\text{ }\mathrm{MeV}$ observed when relativistic pulse impinges under linear polarization. attributed enhanced superponderomotive electrons that were simultaneously measured experiments far beyond...
ABSTRACT Pleural effusion is a common respiratory disease worldwide; however, rapid and accurate diagnoses of tuberculosis pleural (TPE) malignancy (MPE) remain challenging. Although extracellular vesicles (EVs) have been confirmed as promising sources biomarkers, little known about the metabolite compositions its subpopulations their roles in diagnosis effusion. Here, we performed metabolomics lipidomics analysis to investigate characteristics two EV derived from by differential...
Elucidation of the molecular mechanisms involved in pathogenesis coronavirus disease 2019 (COVID-19) may help to discover therapeutic targets.To determine metabolomic profile circulating plasma from COVID-19 survivors with pulmonary sequelae 3 months after discharge, a random, outcome-stratified case-control sample was analyzed. We enrolled 103 recovered patients as well 27 healthy donors, and performed function tests, computerized tomography (CT) scans, laboratory examinations, liquid...
To assess the long-term consequences of coronavirus disease (COVID-19) among health care workers (HCWs) in China (hereafter surviving HCWs).A total 303 HCWs were included. Lung (pulmonary function test, 6-min walk test [6MWT], chest CT), physical (St. George's Respiratory Questionnaire [SGRQ], Modified Medical Research Council dyspnea scale [mMRC], and Borg scale), psychiatric functions (Essen Trauma Inventory) evaluated during 1-year follow-up.Surviving had an abnormal diffusion capacity 1...
Abstract Background Postdischarge immunity and its correlation with clinical features among patients recovered from coronavirus disease 2019(COVID-19) are poorly described. This prospective cross-sectional study explored the inflammatory profiles recovery of COVID-19 at 3 months after hospital discharge. Methods Patients discharged 4 hospitals in Wuhan, asymptomatic (APs) an isolation hotel, uninfected healthy controls (HCs) were recruited. Viral nucleic acid antibody detection, laboratory...
Abstract Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain family member 9 (CARD9) acts as an adapter that mediates the transduction of pro-inflammatory signaling cascades innate immunity; however, its role cardiac injury repair post-MI remains unclear. We found Card9 was one most upregulated Card genes ischemic myocardium mice. CARD9 expression increased considerably...
Abstract Background Malignant tumours seriously threaten human life and health, effective treatments for cancer are still being explored. The ability of SHC SH2 domain-binding protein 1 (SHCBP1) to induce cell cycle disturbance inhibit tumour growth has been increasingly studied, but its dynamic role in the corresponding effects leading mitotic catastrophe DNA damage have rarely studied. Results In this paper, we found that nucleoprotein SHCBP1 exhibits spatiotemporal expression during...
Background CD8+ T cells (Cytotoxic cells, Tc) are known to play a critical role in the pathogenesis of smoking related airway inflammation including chronic obstructive pulmonary disease (COPD). However, how cigarette smoke directly impacts systematic cell and regulatory (Treg) subsets, especially by modulating muscarinic acetylcholine receptors (MRs), has yet be well elucidated. Methods Circulating Tc/Tregs healthy nonsmokers (n = 15), smokers 15) COPD patients 18) were evaluated flow...