A5100336395- Laser Material Processing Techniques
- Advanced machining processes and optimization
- Complex Network Analysis Techniques
- Advanced Surface Polishing Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Opinion Dynamics and Social Influence
- Advanced Machining and Optimization Techniques
- Vehicular Ad Hoc Networks (VANETs)
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Distributed Control Multi-Agent Systems
- Cardiac Fibrosis and Remodeling
- Advanced Data Storage Technologies
- Peer-to-Peer Network Technologies
- Microwave Dielectric Ceramics Synthesis
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Ferroelectric and Piezoelectric Materials
- Model Reduction and Neural Networks
- Skin Protection and Aging
- Opportunistic and Delay-Tolerant Networks
- Cancer Immunotherapy and Biomarkers
- Advanced Graph Neural Networks
- Age of Information Optimization
Huazhong University of Science and Technology
2014-2024
Wuhan National Laboratory for Optoelectronics
2023-2024
Jiangnan University
2024
Union Hospital
2014-2023
Hubei University of Chinese Medicine
2020-2022
Wuhan No.1 Hospital
2020-2022
Hunan University of Science and Technology
2022
Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing
2022
State Key Laboratory of Digital Manufacturing Equipment and Technology
2022
Children's Hospital of Zhejiang University
2022
Introduction: Sepsis-induced acute kidney injury is related to an increased mortality rate by modulating ferroptosis through ginsenoside Rg1. In this study, we explored the specific mechanism of it. Methods: Human renal tubular epithelial cells (HK-2) were transfected with oe-ferroptosis suppressor protein 1 and treated lipopolysaccharide for induction, they then Rg1 inhibitor. Ferroptosis 1, CoQ10, CoQ10H2, intracellular NADH levels in HK-2 assessed Western blot, ELISA kit, NAD/NADH kit....
The continuous dynamical system approach to deep learning is explored in order devise alternative frameworks for training algorithms. Training recast as a control problem and this allows us formulate necessary optimality conditions time using the Pontryagin's maximum principle (PMP). A modification of method successive approximations then used solve PMP, giving rise an algorithm learning. This has advantage that rigorous error estimates convergence results can be established. We also show it...
Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence abundant immunosuppressive cells. Tumor-associated macrophages (TAMs), as dominant population, impede antitumor response; however, underlying mechanisms have not been fully elucidated yet.Single-cell RNA sequencing analysis was performed portray macrophage landscape and revealed mechanism...
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic and systematic inflammation. An abnormal adaptive immune response leads to an imbalance between pro- anti-inflammatory processes. T-helper (Th), T-cytotoxic (Tc) T-regulatory (Treg) cells may play important roles in inflammatory responses. This study was conducted clarify the changes of cytokines T lymphocyte subsets patients with COPD, especially during acute exacerbations (AECOPD). Methods Twenty-three...
Background/Aims: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury. However, whether baicalin plays a role in cardiac hypertrophy remains unknown. Here we investigated the protective effects on induced by pressure overload explored potential mechanisms involved. Methods: C57BL/6J-mice were treated with or vehicle following transverse aortic constriction Sham surgery up...
Abstract Honokiol is a key component of medicinal herb, Magnolia bark. possesses potential pharmacological benefits for many disease conditions, especially cancer. Recent studies demonstrate that exerts beneficial effects on cardiac hypertrophy and doxorubicin (Dox)-cardiotoxicity via deacetylation mitochondrial proteins. However, the mechanisms respiration remain unclear. In present study, we investigate effect in mice subjected to Dox treatment. Oxygen consumption freshly isolated...
CCR2 has been proven to play an important role in diabetes. However, the of diabetic cardiomyopathy not examined. In this study, we investigated effects cardiac on cardiomyopathy. We created a model streptozotocin (STZ)–induced Expression was upregulated hearts STZ-induced mice. knockout significantly improved dysfunction and fibrosis. Moreover, deletion inhibited apoptosis production reactive oxygen species heart. resulted M2 polarization STZ-treated Treatment with inhibitor reversed...
In this article, we investigate the routing problem of packet networks through multiagent reinforcement learning (RL), which is a very challenging topic in distributed and autonomous networked systems. specific, modeled as partially observable Markov decision process (MDP). Since MDP network node not only affected by its neighboring nodes' policies but also traffic demand, it becomes multitask problem. Inspired recent success RL metalearning, propose two novel model-free algorithms, named...
CD4+CD25+Foxp3+ regulatory T cells (Treg cells) have protective effects in wound healing and adverse ventricular remodeling after myocardial infarction (MI). We hypothesize that the interleukin- (IL-) 2 complex comprising recombinant mouse IL-2/anti-IL-2 mAb (JES6-1) attenuates cardiac MI through expansion of Treg. Mice were subjected to surgical left anterior descending coronary artery ligation treated with either PBS or IL-2 complex. The significantly remodeling, as demonstrated by reduced...
Background CD8+ T cells (Cytotoxic cells, Tc) are known to play a critical role in the pathogenesis of smoking related airway inflammation including chronic obstructive pulmonary disease (COPD). However, how cigarette smoke directly impacts systematic cell and regulatory (Treg) subsets, especially by modulating muscarinic acetylcholine receptors (MRs), has yet be well elucidated. Methods Circulating Tc/Tregs healthy nonsmokers (n = 15), smokers 15) COPD patients 18) were evaluated flow...
Abstract BMP and activin membrane-bound inhibitor (BAMBI) is postulated to inhibit or modulate transforming growth factor β (TGF-β) signaling. Furthermore, strong upregulation of BAMBI expression following in vitro infection chronic obstructive pulmonary disease (COPD) lung tissue has been demonstrated. In this study, we investigated whether TGF-β/BAMBI pathway associated with COPD. Blood samples were obtained from 27 healthy controls (HC), 24 smokers (HS) 29 COPD patients. Elevated...
Inter-Vehicular communication is considered to be a promising way improve traffic safety. Among this, it key technology delivery urgent messages and periodical beacons neighbors successfully. In this paper, we propose an Adaptive Collision-Free MAC (ACFM) protocol tailored vehicular networks, based on dynamic TDMA mechanism. our protocol, RoadSide Units (RSUs) are exploited schedule time slots assignment disseminate control information, while the data spread among vehicles. Each RSU...
Background CD4+ T cells in the lung are involved pathogenesis of chronic obstructive pulmonary disease (COPD), although cell subsets and direct effect smoking on these cells, especially expression MRs, have not been comprehensively examined. Methods First, circulating healthy nonsmokers, patients with SCOPD AECOPD were evaluated by flow cytometry. Then, differentiation experiments carried out using RT-PCR, Ki-67/Annexin V antibodies used to measure proliferation apoptosis. We also explored...
The mammalian gonadotropin-inhibitory hormone (GnIH) ortholog, RFamide-related peptide (RFRP), is considered to act on gonadotropin-releasing (GnRH) neurons and the pituitary inhibit gonadotropin synthesis release. However, there little evidence documenting whether 3 (RFRP-3) plays a primary role in inhibition of hypothalamo-pituitary-gonadal (HPG) axis prior onset puberty. present study aimed understand functional significance neuropeptide pubertal development. developmental changes...