A5038685629- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Trace Elements in Health
- Simulation and Modeling Applications
- RNA regulation and disease
- Advanced Computing and Algorithms
- Metallurgy and Material Forming
- High Temperature Alloys and Creep
- Aluminum Alloy Microstructure Properties
- Geochemistry and Geologic Mapping
- Amino Acid Enzymes and Metabolism
- Genetic and phenotypic traits in livestock
- Hypothalamic control of reproductive hormones
- Monoclonal and Polyclonal Antibodies Research
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Microbial metabolism and enzyme function
- Head and Neck Cancer Studies
- Innovative concrete reinforcement materials
- Folate and B Vitamins Research
- Microstructure and mechanical properties
- Biotin and Related Studies
- Ovarian function and disorders
- Metal Alloys Wear and Properties
- Remote Sensing and Land Use
Northwestern Polytechnical University
2019-2024
Chinese Academy of Geological Sciences
2020-2024
China University of Geosciences (Beijing)
2024
Guangzhou Institutes of Biomedicine and Health
2020-2022
Chinese Academy of Sciences
2015-2022
University of Chinese Academy of Sciences
2020-2022
Ministry of Natural Resources
2020-2021
Geological Exploration Technology Institute of Jiangsu Province
2021
National Institute for Viral Disease Control and Prevention
2009-2019
Chongqing University
2007-2018
A 3-D Shenzhen City Web platform based on the virtual reality geographical information system is presented. global browser employed to load multiple types of demand data from city, such as building model data, residents' information, and real-time historical traffic data. Using these a analysis visualization city's are conducted platform. The amount that can be visualized with this very large, GIS-based navigational scheme enables great flexibility access different available sources. All...
This paper takes Shenzhen Fustian comprehensive transportation junction as the case, and makes use of continuous multiple real-time dynamic traffic information to carry out monitoring analysis on spatial temporal distribution passenger flow under different means service capacity from multi-dimensional space-time perspectives such period special period. Virtual reality geographic system is employed present forecasting result.
A 3D Shenzhen city web platform based on WE-BVRGIS is presented. globe browser employed to load all kinds of demanded data the city, such as building model data, residents information, real-time and historical traffic data. Using these analysis visualization concerned massive information are conducted in platform. All presented functions extracted from practical customer demand. The system design has considered some existing Geographic human-computer interaction (GeoHCI) research results.
Background Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive fatal central nervous system disorder, which consists of three main catalogues: sporadic, familial, and iatrogenic CJD. Methodology/Principal Findings In China, the surveillance for CJD started in 2006, covering 12 provincial Centers Disease Control Prevention (CDCs) 15 hospitals. From 2006 to 2010, 624 suspected patients were referred China surveillance. The epidemiological, clinical laboratory features sporadic...
Protein disulfide isomerase (PDI), is sorted to be enzymatic chaperone for reconstructing misfolded protein in endoplasmic reticulum lumen. Recently, PDI has been identified as a link between and neuron apoptosis. However, the potential involved pathogenesis of prion disease remains unknown. In this study, we propose that may function pleiotropic regulator cytotoxicity induced by mutated proteins diseases.To elucidate alterations diseases, levels relevant apoptotic executors 263K infected...
Proteomics changes of brain tissues have been described in different neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. However, the proteomics human prion remains less understood. In study, patterns cortex cerebellum sporadic Creutzfeldt-Jakob disease, fatal familial insomnia, G114V genetic CJD were analyzed with isobaric tags for relative absolute quantitation combined multidimensional liquid chromatography MS analysis, brains from three normal individuals as...
Abstract AMPK is a serine/threonine protein kinase that acts as positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation the macroautophagic system in scrapie-infected experimental rodents and certain human prion diseases, which essential negative mTOR severely inhibited. In this study, brains hamsters infected with scrapie strain 263 K cell line SMB-S15 were analysed. The results showed an up-regulated trend AMPK-Thr172,...
Objective To identify the features of Chinese genetic prion diseases. Methods Suspected Creutzfeldt-Jakob disease (CJD) cases that were reported under CJD surveillance diagnosed and subtyped using diagnostic criteria issued by WHO. The general information concerning patient, their clinical, MRI EEG data, results CSF 14-3-3 PRNP sequencing carefully collected from database national program analyzed SPSS 11.5 statistical software program. Results Since 2006, 69 patients with diseases as having...
Transmissible spongiform encephalopathy (TSE) diseases are known to be zoonotic that can infect different kinds of animals. The transmissibility TSE, like other infectious diseases, shows marked species barrier, either being unable heterologous or difficult form transmission experimentally. similarity the amino acid sequences PrP among is believed one elements in controlling TSE interspecies. Other factors, such as prion strains and host's microenvironment, may also participate process. Two...
Aero engine design necessitates crucial components, such as turbine discs, to be highly stable in high-temperature environments. Therefore, the accurately determining of mechanical properties and microstructure evolution these components under long-term exposure is significant engineering scientific value. Herein, we systematically analyzed performance a Ni-based superalloy during exposure, explored relationship between service conditions yield strength, introduced novel strength decay...
The mammalian gonadotropin-inhibitory hormone (GnIH) ortholog, RFamide-related peptide (RFRP), is considered to act on gonadotropin-releasing (GnRH) neurons and the pituitary inhibit gonadotropin synthesis release. However, there little evidence documenting whether 3 (RFRP-3) plays a primary role in inhibition of hypothalamo-pituitary-gonadal (HPG) axis prior onset puberty. present study aimed understand functional significance neuropeptide pubertal development. developmental changes...