A5053459383- Photonic and Optical Devices
- Photonic Crystals and Applications
- Advanced Fiber Laser Technologies
- Optical Coatings and Gratings
- Advanced Fiber Optic Sensors
- Prion Diseases and Protein Misfolding
- Advanced Photonic Communication Systems
- Optical Network Technologies
- Neurological diseases and metabolism
- Photorefractive and Nonlinear Optics
- Microwave Engineering and Waveguides
- GaN-based semiconductor devices and materials
- Trace Elements in Health
- Plasmonic and Surface Plasmon Research
- Phase-change materials and chalcogenides
- Neural Networks and Reservoir Computing
- RNA regulation and disease
- Dark Matter and Cosmic Phenomena
- Gas Sensing Nanomaterials and Sensors
- ZnO doping and properties
- Infrared Target Detection Methodologies
- Semiconductor Quantum Structures and Devices
- Cooperative Communication and Network Coding
- Semiconductor Lasers and Optical Devices
- Neutrino Physics Research
Jiangsu Normal University
2024-2025
Soochow University
2023-2024
Nanjing Brain Hospital
2024
Nanjing Medical University
2019-2024
Anhui University of Traditional Chinese Medicine
2023-2024
Nankai University
2005-2024
Jiangnan University
2019-2023
Xidian University
2009-2023
China Mobile (China)
2023
Anhui University
2023
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we demonstrated potent IFN immunogenicity of nucleic acid–containing (NA-containing) amyloid fibrils in the periphery. Here, investigated whether associated with β-amyloidosis inside brain contributes to neuropathology. An IFN-stimulated gene (ISG) signature was detected brains multiple murine Alzheimer disease (AD) models, phenomenon also observed WT mouse challenged generic NA-containing...
A compact and high extinction ratio polarization beam splitter using subwavelength grating (SWG) couplers is proposed characterized, where the SWG are located between two input/output strip waveguides, including SWG-based transitions combined at both ends. The TM mode can be confined well in waveguide transmits along it with nearly neglected coupling, while TE undergoes a strong coupling transferred to adjacent help of due dissimilar modal characteristics cutoff conditions these...
Stable laser emission with ultra-narrow linewidth plays an important role in making fundamental scientific breakthroughs. Here, we propose and demonstrate a new technique for the generation of highly stable based on stimulated Brillouin scattering combination frequency-shifted optical injection locking mechanism. The performance is characterized via delayed self-heterodyne interference system, where white frequency noise floor ∼20 mHz2/Hz, corresponding to about 63 mHz. maximum deviation...
We propose and demonstrate a novel, to the best of our knowledge, scheme for extracting amplifying single comb line with high signal-to-noise ratio (SNR) from femtosecond mode-locked laser (FMLL). The is realized based on combination pulse repetition-rate multiplication, optical injection locking, polarization-pulling-attributes stimulated Brillouin scattering. SNR selected amplified more than 70 dB, its frequency can be tuned at an arbitrary position over whole range FMML. white noise floor...
Ultralow-noise microwaves are essential in a wide variety of scientific and technological applications, such as metrology, radars, communications. Here, we propose demonstrate scheme for generating an ultralow-noise microwave signal using Brillouin optical frequency comb (OFC), which is based on the stimulated scattering combination with frequency-shifted injection locking mechanism. The generated two intra-cavity lasers used pump eventual formation OFC thus via cascaded four-wave mixing...
Protein disulfide isomerase (PDI), is sorted to be enzymatic chaperone for reconstructing misfolded protein in endoplasmic reticulum lumen. Recently, PDI has been identified as a link between and neuron apoptosis. However, the potential involved pathogenesis of prion disease remains unknown. In this study, we propose that may function pleiotropic regulator cytotoxicity induced by mutated proteins diseases.To elucidate alterations diseases, levels relevant apoptotic executors 263K infected...
Macroautophagy is an important process for removing misfolded and aggregated protein in cells, the dysfunction of which has been directly linked to increasing number neurodegenerative disorders. However, details macroautophagy prion diseases remain obscure. Here we demonstrated that terminal stages scrapie strain 263K-infected hamsters human genetic diseases, microtubule-associated 1 light chain 3 (LC3) was converted from cytosolic form autophagosome-bound membrane form. substrate...
Developing general methods to fabricate water-dispersible and biocompatible fluorescent probes will promote different biological visualization applications. Herein, we report a metal-facilitated method ultrabright green-emissive nanodots via the one-step solvothermal treatment of rose bengal, ethanol, various metal ions. These metal-doped show good water dispersity, ultrahigh photoluminescence quantum yields (PLQYs) (e.g., PLQY Fe-doped (FeNDs) was ∼97%), low phototoxicity. Owing...
Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au...
A compact polarization beam splitter (PBS) for silicon-based slot waveguides is proposed, where an asymmetrical multimode waveguide (AMW), cut by a right angle at one corner, employed to efficiently separate the TE and TM modes. With unique modal properties of waveguides, input mode almost passes through AMW enters into bar port, while forms mirror image cross port due self-imaging effect. Tapered structures S-bend are incorporated PBS enhancing performance. Results show that with 2.3 μm in...
Abstract On-chip polarization manipulation is pivotal for silicon-on-insulator material platform to realize polarization-transparent circuits and polarization-division-multiplexing transmissions, where splitters rotators are fundamental components. In this work, we propose an ultracompact high efficient silicon-based splitter-rotator (PSR) using a partially-etched subwavelength grating (SWG) coupler. The proposed PSR consists of taper-integrated SWG coupler combined with waveguide between...
Optical excitation is widely acknowledged as one of the most effective means balancing sensor responses and response/recovery properties at room temperature (RT, 25 °C). Moreover, noble metals have been proven to be suitable photosensitizers for optical excitation. Localized surface plasmon resonance (LSPR) determines liberalization quasi-free electrons in under light irradiation, numerous injected semiconductors will greatly promote generation chemisorbed oxygen, thus elevating response. In...
A compact polarization rotator (PR) for silicon-based slot waveguides is proposed, where a metal strip of aluminum (Al) embedded in its upper-claddings. With the features asymmetric hybrid plasmonic waveguide induced by strip, an optimal optical axis rotation angle 45° realized, leading to high conversion efficiency (PCE). The numerical results show that PR 11.6 μm length at wavelength 1.55 achieved with PCE and insertion loss 97.6% 0.86 dB TM-to-TE conversion, respectively. In addition,...
A compact TE-pass polarizer for silicon-based slot waveguides is proposed by utilizing a strip waveguide right above the and two identical metal strips symmetrically located on its outer sides. With unique modal features of optimal designs vertical structure, only input TE mode can directly output, while TM will be coupled to upper waveguides, thus, an efficient realized. Moreover, added help enhance device performance significantly using their hybrid plasmonic effects. Results show that 3.2...
A novel, to the best of our knowledge, approach generate frequency-tunable microwave sources with low-phase-noise based on a Brillouin laser frequency comb is proposed and experimentally demonstrated. The generated by combining stimulated scattering, shifting optical injection locking, modulation sideband locking (MSOIL), four-wave mixing effects. By beating lines, an extremely low-level phase noise –120 dBc/Hz at 10-kHz offset. signal can be finely tuned in steps cavity mode spacing (i.e.,...
Abstract Background Microglial activations have been described in different subtypes of human prion diseases such as sporadic Creutzfeldt-Jakob disease (CJD), variant CJD, Kuru and Gerstmann-Sträussler-Scheinker (GSS). However, the situation microglia other genetic fatal familial insomnia (FFI) CJD remains less understood. The brain was evaluated comparatively between FFI, G114V sCJD cases study. Methods Specific Western blots, immunohistochemical immunofluorescent assays were used to detect...
A compact silicon-based polarization splitter (PS) is proposed using a three-guide directional coupler composed of silicon nanowire in the center and two horizontal/vertical hybrid-plasmonic waveguides (HPWs) at outer sides. Utilizing evanescent coupling, injected TE/TM modes central can be only coupled to HPWs, leading separation input polarizations. Moreover, improve extinction ratio (ER), an S-bend connecting with vertical HPW employed. Results show that coupling length 6.5 (4.5) μm...
Efficient fiber-to-chip coupling is a key issue in the field of integrated optics and photonics due to lack on-chip silicon light source at present. Here, we propose silicon-based edge coupler by use subwavelength grating (SWG)-assisted structure. The conversion region composed trident-shaped SWG center two matched strip waveguides on both sides. To achieve high mode match between fiber waveguide realize low-loss transmission on-chip, have divided into three parts determined their optimum...