A5100662832- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Radiomics and Machine Learning in Medical Imaging
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Analysis
- COVID-19 diagnosis using AI
- Protein Degradation and Inhibitors
- MRI in cancer diagnosis
- Vehicle emissions and performance
- Transcranial Magnetic Stimulation Studies
- Glioma Diagnosis and Treatment
- Neurobiology of Language and Bilingualism
- Brain Tumor Detection and Classification
- Single-cell and spatial transcriptomics
- Advanced Memory and Neural Computing
- AI in cancer detection
- Traditional Chinese Medicine Studies
- Advanced Combustion Engine Technologies
- Stroke Rehabilitation and Recovery
University of Electronic Science and Technology of China
2020-2025
Thomas Jefferson University
2024-2025
Qilu Hospital of Shandong University
2025
Nanjing University
2016-2024
Nanjing General Hospital of Nanjing Military Command
2016-2024
Nanjing Medical University
2019-2024
Drexel University
2024
Weatherford College
2024
Southern Medical University
2018-2023
Universitätsmedizin Greifswald
2022-2023
Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability, and may be beneficial for motor recovery after stroke. However, the neuroplasticity effects of rTMS have not been thoroughly investigated in early stage To comprehensively assess high- low-frequency repetitive stimulations on stroke patients, using a randomized controlled trial based clinical, neurophysiological functional imaging assessments. Sixty hospitalized, first-ever ischemic patients (within 2...
Genetic generalized epilepsy is a network disorder typically involving distributed areas identified by classical neuroanatomy. However, the finer topological relationships in terms of continuous spatial arrangement between these systems are still ambiguous. Connectome gradients provide representations human macroscale hierarchy an abstract low-dimensional space embedding functional connectome into set axes. Leveraging gradients, we systematically scrutinized abnormalities gradient patients...
Epilepsies are a group of neurological disorders sharing certain core features, but also demonstrate remarkable pathogenic and symptomatic heterogeneities. Various subtypes epilepsy have been identified with abnormal shift in the brain default mode network (DMN). This study aims to evaluate fine details shared distinct alterations DMN among epileptic subtypes.We collected resting-state functional magnetic resonance imaging (MRI) data from large sample (n = 371) at single center, including...
Subjects with left temporal lobe epilepsy may either show altered hemispheric language lateralization or retain typical, lateralization. Examining the integrity of white matter pathways involved in adaptation maintenance these patients could have important clinical implications for preserving potentiating compensatory mechanisms. We combined task functional magnetic resonance imaging and structural diffusion metrics to determine dependency lobe-based laterality on healthy participants (TLE)...
Global brain ischemia and neurological deficit are consequences of cardiac arrest that lead to high mortality. Despite advancements in resuscitation science, our limited understanding the cellular molecular mechanisms underlying post-cardiac injury have hindered development effective neuroprotective strategies. Previous studies primarily focused on neuronal death, potentially overlooking contributions non-neuronal cells intercellular communication pathophysiology arrest-induced injury. To...
Supersensitive magnetic resonance (MR) imaging requires contrast with extremely high r2 values. However, synthesized nanoparticles generally have a relatively low relaxivity. Magnetosomes saturation magnetization and good biocompatibility shown potential values as MR agents. that target human epidermal growth factor receptor-2 (HER2) were prepared using genetic technology low-frequency sonication. Anti-HER2 affibody of the ability to HER2 was displayed on membrane surface magnetosomes...
Abstract Objective Focal to bilateral tonic–clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic the distribution white matter (WM) pathways associated with node. We implemented more selective, edge‐wise approach allowed for identification individual connections unique FBTCS. Methods T1‐weighted diffusion‐weighted images were obtained...
Abstract Aims Generalised epilepsy is thought to involve distributed brain networks. However, the molecular and cellular factors that render different regions more vulnerable epileptogenesis remain largely unknown. We aimed investigate epilepsy‐related morphometric similarity network (MSN) abnormalities at macroscale level their relationships with microscale gene expressions level. Methods compared MSN of genetic generalised tonic–clonic seizure patients (GGE‐GTCS, n = 101) demographically...
Purpose . This study was aimed at evaluating the motor cortical excitability and connectivity underlying neural mechanism of deficit in acute stroke by combination functional magnetic resonance imaging (fMRI) electrophysiological measures. Methods Twenty-five patients with after ischemic were involved. General linear model dynamic causal analyses applied to fMRI data for detecting motor-related activation effective cortices. Motor determined as a resting threshold (RMT) evoked potential...
Abstract Generalized tonic–clonic seizures (GTCS) are the severest and most remarkable clinical expressions of human epilepsy. Cortical, subcortical, cerebellar structures, organized with different network patterns, underlying pathophysiological substrates genetic associated epilepsy GTCS (GE‐GTCS) focal to bilateral seizure (FE‐FBTS). Structural covariance analysis can delineate features related long‐term effects from seizure. Morphometric MRI data 111 patients GE‐GTCS, FE‐FBTS healthy...
Brain structural covariance network (SCN) can delineate the brain synchronized alterations in a long-range time period. It has been used research of cognition or neuropsychiatric disorders. Recently, causal analysis (CaSCN), winner-take-all and cortex–subcortex (WTA-CSSCN), modulation (MOD-SCN) have expended technology breadth SCN. However, lack user-friendly software limited further application SCN for research. In this work, we developed graphical user interface (GUI) toolkit connectivity...
Abstract Functional connectivity hierarchy is an important principle in the process of brain functional organization and feature reflecting development. However, atypical network Rolandic epilepsy have not been systematically investigated. We examined alteration with age its relation to epileptic incidence, cognition, or underlying genetic factors 162 cases 117 typically developing children, by measuring fMRI multi-axis gradients. characterized contracting slowing expansion gradients,...
The aim of this study was to investigate the clinical outcomes orbital blowout fracture repair by using three-dimensional (3D) printing-assisted fabrication individual titanium mesh. Clinical and radiologic data were analyzed for 12 patients with floor and/or medial wall fractures. Lower eyelid incision used expose Preoperative computed tomographic input into an imaging software rebuild a 3D orbit mirror unaffected side affected replace demolished orbit. A resin model reshaped generated...
This study aimed to delineate cortico-striato-thalamo-cerebellar network profiles based on static and dynamic connectivity analysis in genetic generalized focal epilepsies with tonic-clonic seizures, evaluate its potential for distinguishing these two epilepsy syndromes. A total of 342 individuals participated the (114 patients seizures (GE-GTCS), 114 age- sex-matched bilateral seizure (FE-FBTS), healthy controls). Resting-state fMRI data were examined through functional (dFC) analyses,...
Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical structures are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet to be comprehensively investigated. Furthermore, relationships between macroscale disturbances and microscale molecular chemoarchitectures unclear. High-resolution structural images were acquired from patients with (n = 97) sex- age-matched healthy...