A5047306664- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Epilepsy research and treatment
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural Networks and Applications
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Suicide and Self-Harm Studies
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Complex Systems and Time Series Analysis
- Renal and related cancers
- Single-cell and spatial transcriptomics
University of Electronic Science and Technology of China
2019-2024
Shandong University
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Weatherford College
2024
High Magnetic Field Laboratory
2023
Institute for Biomedicine
2022
Abstract Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between changes MDD and gene expression is unclear. Here, we examine link brain-wide morphometric individuals MDD, using neuroimaging data from two independent cohorts publicly available transcriptomic dataset. Morphometric similarity network (MSN) analysis shows replicable cortical differences compared control...
The human thalamus is an integrative hub richly connected with cortical networks, involving diverse cognitive functions. Emerging evidence suggests that multiscale structural and functional gradients integrate various information across modalities into abstract representation. However, the presence of in its relationship to properties functions remain unknown. We estimated two independent normal cohorts using a novel diffusion embedding analysis. identified main axes connectivity patterns,...
Abstract Neuroimaging studies have uncovered the neural roots of individual differences in human general fluid intelligence ( Gf ). is characterized by function specific circuits brain gray-matter; however, association between and white-matter (WM) remains unclear. Given reliable detection blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals WM, we used a functional, rather than an anatomical, neuromarker WM to identify . We collected longitudinal BOLD-fMRI...
Genetic generalized epilepsy is a network disorder typically involving distributed areas identified by classical neuroanatomy. However, the finer topological relationships in terms of continuous spatial arrangement between these systems are still ambiguous. Connectome gradients provide representations human macroscale hierarchy an abstract low-dimensional space embedding functional connectome into set axes. Leveraging gradients, we systematically scrutinized abnormalities gradient patients...
The topological organization of the cerebral cortex provides hierarchical axes, namely gradients, which reveal systematic variations brain structure and function. However, macroscopic morphology how it constrains cortical function along organizing axes remains unclear. We map gradient morphometric similarity (MS) connectome, combining multiple features conceptualized as a "fingerprint" an individual's brain. principal MS is anchored by motor sensory cortices at two extreme ends, are reliable...
Epilepsies are a group of neurological disorders sharing certain core features, but also demonstrate remarkable pathogenic and symptomatic heterogeneities. Various subtypes epilepsy have been identified with abnormal shift in the brain default mode network (DMN). This study aims to evaluate fine details shared distinct alterations DMN among epileptic subtypes.We collected resting-state functional magnetic resonance imaging (MRI) data from large sample (n = 371) at single center, including...
The human brain is organized as segregation and integration units follows complex developmental trajectories throughout life. cortical manifold provides a new means of studying the brain’s organization in multidimensional connectivity gradient space. However, how morphometric changes across lifespan remains unclear. Here, leveraging structural magnetic resonance imaging scans from 1,790 healthy individuals aged 8 to 89 years, we investigated age-related global, within- between-network...
Intersubject variability is a fundamental characteristic of brain organizations, and not just "noise". Although intrinsic functional connectivity (FC) unique to each individual varies across gray-matter, the underlying mechanisms intersubject in white-matter (WM) remain unknown. This study identified WMFC variabilities determined genetic basis macroscale imaging 45 healthy subjects. The localization pattern WM heterogeneous, with most observed heteromodal cortex. regions expression profiles...
Individuals with depression have the highest lifetime prevalence of suicide attempts (SA) among mental illnesses. Numerous neuroimaging studies developed biomarkers from task-related neural activation in depressive patients SA, but findings are inconsistent. Empowered by contemporary interconnected view as a system disorder, we sought to identify specific brain circuit utilizing published heterogeneous activations. We systematically reviewed all cognitive and emotional functional MRI that...
Even with an overarching functional dysconnectivity model of adolescent-onset schizophrenia (AOS), there have been no connectome (FC) biomarkers identified for predicting patients' specific symptom domains. Adolescence is a period dramatic brain maturation, substantial interindividual variability in anatomy. However, existing group-level hypotheses AOS lack precision terms neuroanatomical boundaries. This study aimed to identify individual-specific FC associated schizophrenic manifestation...
Abstract Background and Hypothesis Schizophrenia is a polygenetic mental disorder with heterogeneous positive negative symptom constellations, associated abnormal cortical connectivity. The thalamus has coordinative role in function key to the development of cerebral cortex. Conversely, altered functional organization might relate overarching disruptions schizophrenia, anchored development. Study Design Here, we contrasted resting-state fMRI 86 antipsychotic-naive first-episode early-onset...
Abstract Mapping the functional topology from a multifaceted perspective and relating it to underlying cross-scale structural principles is crucial for understanding structural-functional relationships of cerebral cortex. Previous works have described sensory-association gradient axis in terms coupling between structure function, but largely based on single specific feature, mesoscopic underpinnings are rarely determined. Here we show pattern encoded similarity network data Human Connectome...
Abstract Aims Generalised epilepsy is thought to involve distributed brain networks. However, the molecular and cellular factors that render different regions more vulnerable epileptogenesis remain largely unknown. We aimed investigate epilepsy‐related morphometric similarity network (MSN) abnormalities at macroscale level their relationships with microscale gene expressions level. Methods compared MSN of genetic generalised tonic–clonic seizure patients (GGE‐GTCS, n = 101) demographically...
Abstract White matter (WM) makes up half of the human brain. Compelling functional MRI evidence indicates that white exhibits neural activation and synchronization via a hemodynamic window. However, neurometabolic underpinnings temporal spatial topology remain unknown. By leveraging concurrent [18F]FDG-fPET blood-oxygenation-level-dependent-fMRI, we demonstrated correspondences between blood oxygenation glucose metabolism in brain matter. In scale, found blood-oxygenation-level-dependent...
Abstract Epilepsies are a group of neurological disorders characterized by abnormal spontaneous brain activity, involving multiscale changes in functional organizations. However, it is not clear to what extent the epilepsy-related perturbations activity affect macroscale intrinsic dynamics and microcircuit organizations, that supports their pathological relevance. We collect sample patients with temporal lobe epilepsy (TLE) genetic generalized tonic-clonic seizure (GTCS), as well healthy...
Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical structures are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet to be comprehensively investigated. Furthermore, relationships between macroscale disturbances and microscale molecular chemoarchitectures unclear. High-resolution structural images were acquired from patients with (n = 97) sex- age-matched healthy...
Much recent attention has been directed toward investigating the spatial and temporal organization of brain dynamics, but rules which constrain variation spatio-temporal in functional connectivity under different states remain unclear. Here, we developed a novel computational approach based on tensor decomposition regularization to represent dynamic as linear combination modules time-varying weights. In this approach, co-activating patterns, weights expression modules. We applied model (DDM)...
Abstract Individuals with depression have the highest lifetime prevalence of suicide attempt (SA) among mental illnesses. Numerous neuroimaging studies developed biomarkers from task-related neural activation in depressive patients SA, but findings are inconsistent. Empowered by contemporary interconnected view as a system disorder, we sought to identify specific brain circuit utilizing published heterogeneous activations. We systematically reviewed all cognitive and emotional functional MRI...
<title>Abstract</title> Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical nuclei are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet to be comprehensively investigated. Furthermore, relationships between macroscale disturbances and microscale molecular chemoarchitectures unclear. High resolution structural images were acquired from patients with (n = 97) sex-...
Abstract Deciphering the complex relationship between neuroanatomical connections and functional activity in primate brains remains a daunting task, especially regarding influence of monosynaptic connectivity on cortical activity. Here, we investigate anatomical-functional decompose neuronal-tracing connectome marmoset into series eigenmodes using graph signal processing. These cellular effectively constrain derived from resting-state MRI, uncover patterned cellular-functional decoupling....
Epilepsy is a chronic neurological disease. Here we describe the generation of induced pluripotent stem cells (iPSCs) from patient diagnosed as epilepsy caused by ATP1A2 gene mutation. Induced were developed using non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and C-MYC. The established iPSC line (SDCHi007-A) displayed cell morphology, high expression levels pluripotency markers, differentiation potential in vitro, normal karyotype, remaining original
The topographic organization of the cerebral cortex has been proposed to provide hierarchical axes, as gradients, which revealed systematic variations brain structure and function. However, macroscopic morphology how it constrains cortical function along organizing axis is still unclear. We mapped axes (gradients) morphometric similarity connectome, combined multiple features conceptualized a “fingerprint” an individual’s brain. observed that principal gradient was anchored by motor sensory...