A5047655404- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Gastrointestinal motility and disorders
- Mental Health Research Topics
- Autoimmune and Inflammatory Disorders Research
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Geomechanics and Mining Engineering
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Brain Tumor Detection and Classification
- Migration, Health and Trauma
- Posttraumatic Stress Disorder Research
- Traditional Chinese Medicine Studies
- Single-cell and spatial transcriptomics
- Grief, Bereavement, and Mental Health
- Tryptophan and brain disorders
Wenzhou Medical University
2025
Yangzhou University
2025
Nanjing University
2016-2024
Nanjing General Hospital of Nanjing Military Command
2016-2024
Ningbo University
2021-2024
Princeton University
2023-2024
First Affiliated Hospital of Xiamen University
2022-2024
Nanjing Medical University
2016-2021
Montreal Neurological Institute and Hospital
2020
McGill University
2020
Temporal lobe epilepsy (TLE) is the most common drug-resistant in adults. Although it commonly related to hippocampal pathology, increasing evidence suggests structural changes beyond mesiotemporal lobe. Functional anomalies and their link underlying alterations, however, remain incompletely understood.We studied 30 TLE patients 57 healthy controls using multimodal magnetic resonance imaging (MRI) analyses. All had histologically verified sclerosis underwent postoperative outline extent of...
Abstract Thalamo-cortical pathology plays key roles in both generalized and focal epilepsies, but there is little work directly comparing these syndromes at the level of whole-brain mechanisms. Using multimodal imaging, connectomics, computational simulations, we examined thalamo-cortical cortico-cortical signatures underlying microcircuits 96 genetic (GE) 107 temporal lobe epilepsy (TLE) patients, along with 65 healthy controls. Structural functional network profiling highlighted extensive...
Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its surgical...
Importance Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well emerging data trials, suggest conceptualizing TLE a network disorder. Objective To assess whether brain networks connected to areas of atrophy in hippocampus align topography neuroimaging RNS...
Aging is a complex biological process with sexually dimorphic aspects. Although cognitive aging of
Recent fMRI studies have demonstrated that resting-state functional connectivity (FC) is of nonstationarity. Temporal variability FC reflects the dynamic nature brain activity. Exploring temporal offers a new approach to investigate reorganization and integration networks after stroke. Here, we examined longitudinal alterations in Nineteen stroke patients underwent resting scans across acute stage (within-one-week stroke), subacute (within-two-weeks early chronic (3-4 months stroke). age-...
Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)-a relapsing functional disorder-presents with disrupted brain connections. However, little is known about the alterations of interhemispheric connectivity and underlying structural in IBS. This study combined resting-state magnetic resonance imaging (rs-fMRI) diffusion tensor (DTI) to investigate changes coordination IBS patients. Resting-state images were acquired from 65 patients 67 healthy controls (HCs; matched...
Abstract Aims Generalised epilepsy is thought to involve distributed brain networks. However, the molecular and cellular factors that render different regions more vulnerable epileptogenesis remain largely unknown. We aimed investigate epilepsy‐related morphometric similarity network (MSN) abnormalities at macroscale level their relationships with microscale gene expressions level. Methods compared MSN of genetic generalised tonic–clonic seizure patients (GGE‐GTCS, n = 101) demographically...
Abstract Generalized tonic–clonic seizures (GTCS) are the severest and most remarkable clinical expressions of human epilepsy. Cortical, subcortical, cerebellar structures, organized with different network patterns, underlying pathophysiological substrates genetic associated epilepsy GTCS (GE‐GTCS) focal to bilateral seizure (FE‐FBTS). Structural covariance analysis can delineate features related long‐term effects from seizure. Morphometric MRI data 111 patients GE‐GTCS, FE‐FBTS healthy...
Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. While hippocampal pathology hallmark this condition, emerging evidence indicates that brain alterations extend beyond mesiotemporal epicenter and affect macroscale function cognition. We studied functional reorganization TLE, explored structural substrates, examined cognitive associations. investigated a multisite cohort 95 patients with TLE healthy controls using state-of-the-art multimodal 3T...
Losing an only child is a devastating life event that parent can experience and may lead to post-traumatic stress disorder (PTSD). Social support could buffer against the negative influence of this trauma, but neural mechanism underlying alleviation effect remains poorly understood. In study, voxel-based morphometry was conducted on brain MRI 220 Han Chinese adults who had lost their child. We performed multiple regression analysis investigate associations between social scores - along with...
Abstract Background Losing one's only child is a major traumatic life event that may lead to post-traumatic stress disorder (PTSD); however, the underlying mechanisms of its psychological consequences remain poorly understood. Here, we investigated subregional hippocampal functional connectivity (FC) networks based on resting-state magnetic resonance imaging and deoxyribonucleic acid methylation human glucocorticoid receptor gene ( NR3C1 ) in adults who had lost their child. Methods A total...
Losing one's only child is a major traumatic life event that may lead to posttraumatic stress disorder (PTSD); however, not all parents who experience this trauma develop PTSD. Genetic variants are associated with the risk of developing Catechol-O-methyltransferase (COMT) rs4680 and brain-derived neurotrophic factor (BDNF) rs6265 two most well-described single-nucleotide polymorphisms relate response; neural mechanism underlying their effects on adults lost an remains poorly understood. Two...
Postoperative cognitive dysfunction (POCD) is a common complication of the central nervous system in elderly surgical patients. Structural MRI and arterial spin labelling (ASL) techniques found that grey matter volume cerebral perfusion some specific brain areas are associated with occurrence POCD, but results inconsistent, predictive accuracy low. We hypothesised combination cortical volumetry blood flow yield higher than either methods discriminating individuals who susceptible to POCD...
The stress-related gene FKBP5 has been related to dysregulated glucocorticoid receptor (GR) signaling, showing increased GR sensitivity in trauma-exposed subjects with post-traumatic stress disorder (PTSD) but not those without PTSD. However, the neural mechanism underlying effects of remains poorly understood. Two hundred and thirty-seven Han Chinese adults who had lost their only child were included. Four single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, rs9470080)...
The abnormal brain activity is a pivotal condition for the occurrence of posttraumatic stress disorder. However, dynamic time features intrinsic activities still remain unclearly in PTSD patients. Our study aims to perform resting-state lag analysis (RS-LA) method explore potential propagated patterns We recruited 27 drug-naive patients with PTSD, 33 trauma-exposed controls (TEC), and 30 demographically matched healthy (HC) final data statistics. Both RS-LA conventional voxel-wise functional...
Abstract Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its...