A5077621765- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Pain Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Stock Market Forecasting Methods
- Sleep and Wakefulness Research
- Phagocytosis and Immune Regulation
- Diet and metabolism studies
- Immune cells in cancer
- Attention Deficit Hyperactivity Disorder
- Neurological disorders and treatments
- Advanced Memory and Neural Computing
- Neuroinflammation and Neurodegeneration Mechanisms
- Forecasting Techniques and Applications
- Muscle activation and electromyography studies
- Financial Markets and Investment Strategies
- Autism Spectrum Disorder Research
- Spinal Cord Injury Research
- Transcranial Magnetic Stimulation Studies
Montreal Neurological Institute and Hospital
2023-2025
McGill University
2023-2025
University of British Columbia
2024
Montreal Children's Hospital
2024
Salk Institute for Biological Studies
2016-2023
University of Virginia
2015
Abstract Sensory information from mechanoreceptors and nociceptors in the skin plays key roles adaptive protective motor behaviours. To date, very little is known about how this encoded by spinal cord cell types their activity patterns, particularly under freely behaving conditions. enable stable measurement of neuronal glial mice, we have developed fluorescence imaging approaches based on two- miniaturized one-photon microscopy. We show that distinct cutaneous stimuli activate overlapping...
While the spinal cord is known to play critical roles in sensorimotor processing, including pain-related signaling, corresponding activity patterns genetically defined cell types across laminae have remained challenging investigate. Calcium imaging has enabled cellular measurements behaving rodents but currently limited superficial regions. Here, using chronically implanted microprisms, we imaged sensory and motor-evoked regions at speeds inaccessible by other high-resolution techniques. To...
Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated with pathology paralimbic brain regions, particularly in mesiotemporal lobe. Cognitive dysfunction TLE frequent, and affects episodic memory. Crucially, these difficulties challenge quality life patients, sometimes more than seizures, underscoring need to assess neural processes cognitive improve patient management. Our work harnessed a novel conceptual analytical approach spatial gradients...
The brain is a physically embedded and heavily interconnected system that expresses neural rhythms across multiple time scales. While these dynamics result from the complex interplay of local inter-regional factors, relative contribution such mechanisms cortex remains unclear. Our study explored geometric, microstructural, connectome-level constraints on cortex-wide activity. We leveraged intracranial electroencephalography recordings to derive an intrinsic coordinate human cortical...
Abstract Excitation‐inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I at macroscale, whole‐brain level, and microcircuit‐level mechanisms clinical significance remain incompletely understood. Here, Hurst exponent, an index ratio, computed from resting‐state fMRI time series, microcircuit parameters are simulated using biophysical models. A...
A bstract Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated a complex genetic architecture, but the translation from risk factors to brain vulnerability remains unclear. Here, we examined associations between epilepsy-related polygenic scores for HS (PRS-HS) and structure in large sample of neurotypical children, correlated these signatures case-control findings multicentric cohorts patients TLE-HS. Imaging-genetic analyses revealed PRS-related cortical thinning...
Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its surgical...
Neuroimaging studies in patients with temporal lobe epilepsy (TLE) show widespread brain network alterations beyond the mesiotemporal lobe. Despite critical role of cerebrovascular system maintaining whole-brain structure and function, changes cerebral blood flow (CBF) remain incompletely understood disease. Here, we studied perfusion vascular TLE assessed its associations gray white matter compromises various clinical variables.
Importance Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well emerging data trials, suggest conceptualizing TLE a network disorder. Objective To assess whether brain networks connected to areas of atrophy in hippocampus align topography neuroimaging RNS...
Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. While hippocampal pathology hallmark this condition, emerging evidence indicates that brain alterations extend beyond mesiotemporal epicenter and affect macroscale function cognition. We studied functional reorganization TLE, explored structural substrates, examined cognitive associations. investigated a multisite cohort 95 patients with TLE healthy controls using state-of-the-art multimodal 3T...
ABSTRACT Objective Autism spectrum disorder (ASD) is a pervasive neurodevelopmental condition that associated with atypical brain network organization, prior work suggesting differential connectivity alterations respect to functional connection length. Here, we tested whether connectopathy in ASD specifically relates disruptions long-relative short-range profiles. Our approach combined connectomics geodesic distance mapping, and studied associations macroscale networks, microarchitectural...
ABSTRACT Objectives Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey white matter structures. Evidence supports a progressive condition although the temporal evolution TLE poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural in patients across adult lifespan. We charted both changes explored covariance age-related compartments. Methods studied 769 885...
A bstract Excitation-inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with mounting body previous research focusing on elucidating its cellular manifestations. However, there are limited studies into E/I at macroscale and microcircuit-level mechanisms clinical associations. In our current work, we computed Hurst exponent—a previously validated index ratio—from resting-state fMRI time series, simulated microcircuit parameters using biophysical...
A bstract O bjective Neuroimaging has been the prevailing method to study brain networks in temporal lobe epilepsy (TLE), showing widespread alterations beyond mesiotemporal lobe. Despite critical role of cerebrovascular system maintaining whole-brain structure and function, changes cerebral blood flow (CBF) remain incompletely understood disease. M ethods We studied 24 individuals with pharmaco-resistant TLE 38 healthy adults using multimodal 3T magnetic resonance imaging. compared regional...
Abstract Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its...
BACKGROUND Microsurgical resection of drug-resistant epilepsy–associated perirolandic lesions can lead to postoperative motor impairment. Magnetic resonance imaging (MRI)–guided laser interstitial thermal therapy (MRgLITT) has emerged as a less invasive alternative, offering reduced surgical risks and improved neurological outcomes. Electrophysiological tools routinely used for mapping in resective microsurgery are incompatible with intraoperative MRI. The utilization advanced neuroimaging...
ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean...
Specialization of brain areas and subregions, as well their integration into large-scale networks are key principles in neuroscience. Consolidating both local global cortical organization, however, remains challenging. Our study developed a new approach to map global, cortex-wise similarities microstructure, structural connectivity, functional interactions, integrate these patterns with maps arealization. analysis combined repeated high-field in-vivo 7 tesla (T) Magnetic Resonance Imaging...
Abstract Spinal cord circuits play crucial roles in transmitting and gating cutaneous somatosensory modalities, such as pain, but the underlying activity patterns within across spinal segments behaving mice have remained elusive. To enable measurements, we developed a wearable widefield macroscope with 7.9 mm 2 field of view, subcellular lateral resolution, 2.7 working distance, <10 g overall weight. We show that highly localized painful mechanical stimuli evoke widespread, coordinated...
Over the past twenty years, trading in financial markets has evolved from a human-oriented process to one that is highly automated. One of most influential and revolutionary processes algorithmic trading. The focus this work increase efficiency by improving accuracy intraday volume forecasts, which are used An forecast predicts distribution throughout day, allows traders make better decisions regarding timing quantity their trades. accurate an important input will ultimately improve traders'...
Abstract While the spinal cord is known to play critical roles in sensorimotor processing, including pain-related signaling, corresponding activity patterns genetically defined cell types across laminae have remained elusive. Calcium imaging has enabled cellular measurements behaving rodents but currently limited superficial regions. Using chronically implanted microprisms, we imaged sensory and motor evoked regions at speeds inaccessible by other high-resolution techniques. To enable...