A5062558315- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Cerebrospinal fluid and hydrocephalus
- Face Recognition and Perception
- Advanced Neuroimaging Techniques and Applications
- Barrier Structure and Function Studies
- Receptor Mechanisms and Signaling
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Multiple Sclerosis Research Studies
- Neural and Behavioral Psychology Studies
- Immune Response and Inflammation
- Cardiovascular Syncope and Autonomic Disorders
- Pain Management and Placebo Effect
- Meningioma and schwannoma management
Centre Hospitalier de l’Université de Montréal
2013-2024
Université de Montréal
2015-2024
Hasselt University
2020
Mexican Social Security Institute
2020
Montreal Neurological Institute and Hospital
2009-2018
Concordia University
2018
Hôpital Notre-Dame
2008-2017
Vancouver Biotech (Canada)
2009-2011
Alberta Bible College
2011
Merck Canada Inc. (Canada)
2011
THIS STUDY PROPOSES an anatomically based nomenclature for the internal carotid artery (ICA) that can be applied by all disciplines. In 1938, Fischer published a seminal paper describing five segments of ICA were designated C1 through C5. These on angiographic course intracranial rather than its arterial branches or anatomic compartments. Subsequent attempts to apply modern these numerical failed recognize Fischer's original intent patterns displacement tumors and, therefore, resulted in was...
The blood–brain barrier (BBB) restricts molecular and cellular trafficking between the blood CNS. Although astrocytes are known to control BBB permeability, determinants of this effect remain unknown. We show that angiotensinogen (AGT) produced secreted by is cleaved into angiotensin II (AngII) acts on type 1 receptors (AT ) expressed endothelial cells (ECs). Activation AT passage tracers across human BBB-derived ECs through threonine-phosphorylation tight junction protein occludin its...
Recent evidence suggesting that some epilepsy surgery failures could be related to unrecognized insular have led us lower our threshold sample the insula with intracerebral electrodes. In this study, we report experience resulting from change in strategy.During period extending October 2004 June 2007, 18 patients had an intracranial study including 10 coverage. The decision electrodes was made context of (1) nonlesional parietal lobe-like epilepsy; (2) frontal (3) temporal and (4) atypical...
Blood-derived myeloid antigen-presenting cells (APCs) account for a significant proportion of the leukocytes found within lesions multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). These APCs along with activated microglia are thought to be pivotal in initiation central nervous system (CNS)-targeted immune response MS EAE. However, exact molecules that direct migration from periphery across blood-brain barrier (BBB) remain largely unknown.We identified Ninjurin-1...
DICAM contributes to the pathogenesis of autoimmune neuroinflammation by promoting migration T H 17 lymphocytes across blood-brain barrier.
Dysregulation of the blood-brain barrier (BBB) and transendothelial migration immune cells are among earliest central nervous system changes partaking in lesion formation both multiple sclerosis (MS) its early clinical form, clinically isolated syndrome. Evidence for anti-inflammatory effects 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors within arose from studies demonstrating that statins improve signs animal model MS reduce number gadolinium-enhancing lesions MS.We sought to...
To characterize the pathologic findings of temporal lobe epilepsy (TLE) in children undergoing lobectomy for refractory seizures and to correlate these with clinical presentation.The authors reviewed charts all who underwent anterior TLE from 1979 through 1999. A new neuropathologic analysis was performed blinded features outcome.Twenty-two met inclusion criteria. Mean age at onset 3 years, 7 months (range 1 month 10 years). surgery 11 18 All patients had complex partial seizures, 48%...
<b>Objective:</b> In patients with nonlesional frontal lobe epilepsy (FLE), the delineation of epileptogenic zone is difficult. Therefore these are often not considered for surgery due to an unclear seizure focus. The aim this study was investigate whether EEG-fMRI can add useful information in preoperative evaluation patients. <b>Methods:</b> Nine FLE were studied using a 3 T scanner. Spike-related blood oxygen level dependent (BOLD) signal changes compared topography spikes and PET SPECT...
Summary Purpose To study the utility of magnetoencephalography ( MEG ) in patients with refractory insular epilepsy. Covered by highly functional temporal, frontal, and parietal opercula, insular‐onset seizures can manifest a variety ictal symptoms falsely leading to diagnosis or lobe seizures. Lack recognition may be responsible for some epilepsy surgery failures. Methods We retrospectively reviewed analyzed data 14 defined through intracranial electroencephalography EEG presence an...
Using light, we are able to visualize the hemodynamic behavior of brain better understand neurovascular coupling and cerebral metabolism. In vivo optical imaging tissue using endogenous chromophores necessitates spectroscopic detection ensure molecular specificity as well sufficiently high speed signal-to-noise ratio, allow dynamic physiological changes be captured, isolated, used surrogate pathophysiological processes. An system is introduced a 16-bands on-chip hyperspectral camera. this...
Activated leukocyte cell adhesion molecule mediates B lymphocyte migration across central nervous system barriers.
Object The insular region has long been neglected in the investigation and treatment of refractory epilepsy. Surgery is rarely performed because risk injury to opercula, arteries transiting on surface insula, deep structures such as basal ganglia internal capsule. This study was undertaken report results surgery using modern microsurgical techniques patients with Methods authors a retrospective cases involving who underwent for lesions associated epilepsy over last 10 years. In majority...
Purpose: We present two methods of implantation for the investigation suspected insular and perisylvian epilepsy that combine depth subdural electrodes to capitalize on advantages each technique. Methods: Retrospective study all intracranial EEG studies included from 2004–2010. Patients were divided according scheme. The first method (type 1) consisted a craniotomy, insertion after microdissection sylvian fissure, orthogonal mesiotemporal structures with neuronavigation, coverage adjacent...
The trafficking of autoreactive leucocytes across the blood-brain barrier endothelium is a hallmark multiple sclerosis pathogenesis. Although represents one main CNS borders to interact with infiltrating leucocytes, its exact contribution neuroinflammation remains understudied. Here, we show that Mcam identifies inflammatory brain endothelial cells pro-migratory transcriptomic signature during experimental autoimmune encephalomyelitis. In addition, MCAM was preferentially upregulated on in...
The question of whether distinct or similar neural substrates underlie primary emotions has not been resolved yet. To address this issue, we used fMRI to scan professional actors during self-induced states sadness and happiness. Results demonstrated that, relative an emotionally Neutral state, both the Sad Happy were associated with significant loci activation, bilaterally, in orbitofrontal cortex, left medial prefrontal ventrolateral anterior temporal pole, right pons. These activation...
Surgery in the insular region is considered challenging because of its vascular relationships, proximity functional structures, and deep location sylvian fissure. The authors report incidence consequences ischemic lesions after operculoinsular corticectomy for refractory epilepsy.The retrospectively reviewed data all patients who underwent an resection with or without opercular epilepsy at their center. All postoperative MRI, enabling a radiological analysis as result corticectomies....