A5010234112- Epilepsy research and treatment
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Sleep and related disorders
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Pharmacological Effects and Toxicity Studies
- Clinical Reasoning and Diagnostic Skills
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Sleep and Work-Related Fatigue
- Advanced Memory and Neural Computing
- Anesthesia and Neurotoxicity Research
- Hemispheric Asymmetry in Neuroscience
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Obstructive Sleep Apnea Research
- Atomic and Subatomic Physics Research
- Artificial Intelligence in Healthcare and Education
- Migraine and Headache Studies
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
McGill University
2020-2025
Centre Hospitalier Régional et Universitaire de Nancy
2024
Montreal Neurological Institute and Hospital
2020-2024
Duke Medical Center
2024
Henan University
2024
Duke University
2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Hebrew University of Jerusalem
2017-2022
Institute of Life Sciences
2022
Objective Epileptic spikes are the traditional interictal electroencephalographic (EEG) biomarker for epilepsy. Given their low specificity identifying epileptogenic zone (EZ), they given only moderate attention in presurgical evaluation. This study aims to demonstrate that it is possible identify specific spike features intracranial EEG optimally define EZ and predict surgical outcome. Methods We analyzed on stereo‐EEG segments from 83 operated patients 2 epilepsy centers (37 Engel IA)...
Abstract Sleep spindles are the hallmark of N2 sleep and attributed a key role in cognition. Little is known about impact epilepsy on oscillations underlying sleep-related functions. This study assessed changes global spindle rate patients with epilepsy, analysed distribution relation to epileptic focus, performed correlations neurocognitive function. Twenty-one drug-resistant focal (12 females; mean age 32.6 ± 10.7 years [mean SD]) 12 healthy controls (3 24.5 3.3 years) underwent combined...
Abstract Stereo-electroencephalography (SEEG) is the gold standard to delineate surgical targets in focal drug-resistant epilepsy. SEEG uses electrodes placed directly into brain identify seizure-onset zone (SOZ). However, its major constraint limited coverage, potentially leading misidentification of ‘true’ SOZ. Here, we propose a framework assess adequate sampling by coupling epileptic biomarkers with their spatial distribution and measuring system’s response perturbation this coupling. We...
The automated interpretation of clinical electroencephalograms (EEGs) using artificial intelligence (AI) holds the potential to bridge treatment gap in resource-limited settings and reduce workload at specialized centers. However, facilitate broad implementation, it is essential establish generalizability across diverse patient populations equipment. We assessed whether SCORE-AI demonstrates diagnostic accuracy comparable that experts when applied a geographically different population,...
Abstract Objective The use of electrical source imaging (ESI) in assessing the interictal epileptic discharges (IEDs) is gaining increasing popularity presurgical work‐up patients with drug‐resistant focal epilepsy. While vigilance affects ability to locate IEDs and identify epileptogenic zone, we know little about its impact on ESI. Methods We studied overnight high‐density electroencephalography recordings were marked visually each state, examined sensor space. ESIs calculated compared...
Abstract Electro/Magneto‐EncephaloGraphy (EEG/MEG) source imaging (EMSI) of epileptic activity from deep generators is often challenging due to the higher sensitivity EEG/MEG superficial regions and spatial configuration subcortical structures. We previously demonstrated ability coherent Maximum Entropy on Mean (cMEM) method accurately localize cortical their extent. Here, we propose a depth‐weighted adaptation cMEM more accurately. These methods were evaluated using realistic...
Rapid eye movement (REM) sleep reduces the rate and extent of interictal epileptiform discharges (IEDs). Breakthrough epileptic activity during REM is therefore thought to best localize seizure onset zone (SOZ). We utilized polysomnography combined with direct cortical recordings investigate influences anatomical locations time night on suppressive effect IEDs.Forty consecutive patients drug-resistant focal epilepsy underwent stereo-electroencephalography presurgical evaluation. Ten-minute...
Abstract Morning awakening is part of everyday life. Surprisingly, information remains scarce on its underlying neurophysiological correlates. Here simultaneous polysomnography and stereo‐electroencephalography recordings from 18 patients are used to assess the spectral connectivity content process at a local level 15 min before after awakening. Awakenings non‐rapid eye movement sleep accompanied by widespread increase in ripple (>80 Hz) power fronto‐temporal parieto‐insular regions, with...
Journal Article Corrected proof Enhanced thalamocortical functional connectivity during rapid-eye-movement sleep sawtooth waves Get access Laure Peter-Derex, Peter-Derex Center for Sleep Medicine and Respiratory Diseases, Croix-Rousse Hospital, University Hospital of Lyon, Lyon 1 University, FranceLyon Neuroscience Research Center, CNRS UMR5292/INSERM U1028, France Corresponding author. Centre 103 Grande rue de la Croix-Rousse, 69004 France. Email: laure.peter-derex@chu-lyon.fr;...
<h3>Importance</h3> Stereoelectroencephalography (SEEG) has become the criterion standard in case of inconclusive noninvasive presurgical epilepsy workup. However, up to 40% patients are subsequently not offered surgery because seizure-onset zone is less focal than expected or cannot be identified. <h3>Objective</h3> To predict focality SEEG, 5-point 5-SENSE score was developed and validated. <h3>Design, Setting, Participants</h3> This a monocentric cohort study for development followed by...
Abstract Study Objectives Whereas there is plenty of evidence on the influence epileptic activity non-rapid eye movement (NREM) sleep macro- and micro-structure, data impact epilepsy rapid (REM) remains sparse. Using high-density electroencephalography (HD-EEG), we assessed global focal disturbances sawtooth waves (STW) as cortically generated oscillations REM in patients with epilepsy. Methods Twenty-two drug-resistant (13 females; mean age, 32.6 ± 10.7 years; 12 temporal lobe epilepsy)...
As an intrinsic component of sleep architecture, arousals represent intermediate state between and wakefulness play important role in sleep-wake regulation. They have been defined all-or-none manner, whereas they actually present a wide range scalp-electroencephalography (EEG) activity patterns. It is poorly understood how these differ their mechanisms. Stereo-EEG (SEEG) provides the unique opportunity to record intracranial activities superficial deep structures humans. Using combined...
Well-documented sleep datasets from healthy adults are important for pattern analysis and comparison with a wide range of neuropsychiatric disorders. Currently, available acquired using low-density arrays minimum four electrodes in typical montage. The low spatial resolution is thus prohibitive the structure sleep. Here we introduce an open-access dataset 29 (13 female, aged 32.17 ± 6.30 years) at Montreal Neurological Institute. includes overnight polysomnograms high-density scalp...
Sleep has important influences on focal interictal epileptiform discharges (IEDs), and the rates spatial extent of IEDs are increased in non-rapid eye movement (NREM) sleep. In contrast, influence sleep seizures is less clear, its effects seizure topography poorly documented. We evaluated NREM ictal spatiotemporal dynamics contrasted these with network dynamics.We included patients drug-resistant epilepsy who underwent continuous intracranial electroencephalography (iEEG) depth electrodes....
Corticosteroids and adrenocorticotropic hormone (ACTH) are the therapy of choice to treat infantile spasms. However, systematic studies about their use in other types childhood epilepsies remain rare ACTH can have serious side effects. This study compares interictal epileptic activity (IEA) burden (% electroencephalography (EEG) time with IEDs) children genetic drug-resistant epilepsy before after a standardized treatment pulsatile corticoid (PCT).
Seminal animal studies demonstrated the role of sleep oscillations such as cortical slow waves, thalamocortical spindles, and hippocampal ripples in memory consolidation. In humans, whether are involved sleep-related processes is less clear. Here, we explored interactions between (measured traits) general episodic abilities 26 adults with drug-resistant temporal lobe epilepsy who performed scalp-intracranial electroencephalographic recordings neuropsychological testing, including two...
ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean...
ABSTRACT Objective Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source imaging FO 256-channel high-density EEG (HD-EEG) is useful for EZ identification. Methods analyzed HD-EEG recordings 10 focal drug-resistant epilepsy patients with seizure-free postsurgical outcome. marked candidate events at time epileptic spikes and verified them by screening an...
Ketogenic diet (KD) and pulsatile dexamethasone therapy (PDT) are commonly used in the treatment of children with drug resistant epilepsy. Potential side effects KD hypoglycemia, whereas PDT might lead to hyperglycemia. One practical option measure glucose concentrations regularly is flash monitoring system (FGM). In this single-center study Germany, two pediatric patients epilepsy (age: 6.0 6.8 years) received FGM from beginning over six months, year 2020, one patient (9.8 was observed for...