A5101865950- Functional Brain Connectivity Studies
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Ubiquitin and proteasome pathways
- Genetic Associations and Epidemiology
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- Traumatic Brain Injury Research
- Cancer-related Molecular Pathways
- Posttraumatic Stress Disorder Research
- Mental Health Research Topics
- Microtubule and mitosis dynamics
- Glutathione Transferases and Polymorphisms
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Advanced MRI Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Steroid Chemistry and Biochemistry
- Marine Sponges and Natural Products
- Genetic Neurodegenerative Diseases
- Identity, Memory, and Therapy
- Microbial metabolism and enzyme function
- CRISPR and Genetic Engineering
- Effects of Radiation Exposure
Yixing People's Hospital
2024
Jiangsu University
2024
Chinese PLA General Hospital
2021-2023
Heilongjiang University
2023
Dahua Hospital
2022
Hainan General Hospital
2016-2020
Hainan Medical University
2020
Zhejiang Chinese Medical University
2019
Beijing Children’s Hospital
2019
Jinan University
2018
Objective Gray matter loss in the limbic structures was found recent onset post traumatic stress disorder (PTSD) patients. In present study, we measured regional gray volume trauma survivors to verify hypothesis that may cause different with and without PTSD. Method High resolution T1-weighted magnetic resonance imaging (MRI) were obtained from coal mine flood disaster (n = 10) PTSD 20 no exposed normal controls. The voxel-based morphometry (VBM) method used measure three groups,...
Objective: Bipolar disorder (BD) is a common psychiatric disease. Although structural and functional abnormalities of the cerebellum in BD patients have been reported by recent neuroimaging studies, cerebellar-cerebral connectivity (FC) has not yet examined. The present study aims to investigate FC between cerebrum, particularly central executive network (CEN) default-mode (DMN) bipolar II (BD II). Methods: Ninety-four with unmedicated depression 100 healthy controls (HCs) underwent...
Background: A growing body of evidence indicates alterations in metabolite levels and enzyme activities associated with the conversion tryptophan (TRP) throughout course cerebral ischemia. In this study we aim to explore potential relationship between TRP metabolism clinical prognosis acute ischemic stroke (AIS) patients mainland China. Methods: Blood samples were obtained from a cohort 304 AIS patients. The concentrations ten metabolites quantified utilizing liquid chromatography-tandem...
It is generally acknowledged that drug dependence connected with abnormal functional organization in the individual's brain. The present study aimed to identify anterior cingulate cortex (ACC) abnormality cerebral networks involved betel quid (BQD) by resting-state connectivity (rsFC) using magnetic resonance imaging (fMRI). With fMRI data measured from 33 BQD individuals and 32 non-addicted age-, sex-, education-matched healthy controls, we inquired into BQD-related changes FC between...
Circulating microRNAs (miRNAs) potentially carry disease-specific information. In the current study, we aim to characterize miRNA signature in plasma from dilated cardiomyopathy (DCM) patients and assess possible correlation between expression levels of circulating miRNAs symptom severity DCM patients.Using microarray-based profiling, compared samples 4 3 healthy controls. The selected differentially expressed, upregulated (miR-3135b, miR-3908 miR-5571-5p) were validated independently 19 20...
Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal aging and Alzheimer's disease. Previous studies have found that neuronal activity functional connectivity impaired in many networks, especially the default mode network (DMN), which related to significantly memory functions aMCI patients. However, few focused on effective of DMN its subsystems The posterior cingulate cortex (PCC) considered crucial region key subsystem. In this study, using coefficient Granger...
Objective: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized individuals with Betel Quid Dependence (BQD) have functional connectivity alterations can be described by long- and short-range density(FCD) maps. Methods: tested this hypothesis using magnetic resonance imaging (fMRI) data from subjects Han ethnic group in Hainan, China. Here, we examined BQD (n = 33)...
Numerous studies have indicated that smokers an increased risk of developing ischemic stroke. However, less is known about the causal relationship between cigarette smoking and stroke subtypes. In present study, we aim to determine whether genetically predicted was associated with subtypes using Mendelian randomization (MR).We used summary-level genetic association data from MEGASTROKE consortium, including 438,847 individuals European ancestry (34,217 cases 404,630 controls). We 176 single...
Abstract Background Comorbidities of coronavirus disease 2019 (COVID-19)/coronary heart (CHD) pose great threats to outcomes, yet little is known about their shared pathology. The study aimed examine whether comorbidities COVID-19/CHD involved genetic pathology, as well clarify the variants predisposing risks common COVID-19 severity and CHD risks. Methods By leveraging publicly available summary statistics, we assessed genetically determined causality between with bidirectional Mendelian...
The abnormal brain activity is a pivotal condition for the occurrence of posttraumatic stress disorder. However, dynamic time features intrinsic activities still remain unclearly in PTSD patients. Our study aims to perform resting-state lag analysis (RS-LA) method explore potential propagated patterns We recruited 27 drug-naive patients with PTSD, 33 trauma-exposed controls (TEC), and 30 demographically matched healthy (HC) final data statistics. Both RS-LA conventional voxel-wise functional...
Glutathione S-transferases (GSTs) is a genetic factor for many diseases and exhibits great diversities among various populations. We assessed association of the genotypes Omega-1 (GSTO1) A140D with ethnicity in China. Peripheral blood samples were obtained from 1314 individuals 14 ethnic groups. Polymorphisms GSTO1 measured using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Logistic regression was employed to adjustment regional factor. The frequency 140A...
Abstract Background The structural changes recent-onset posttraumatic stress disorder (PTSD) subjects were rarely investigated. This study was to compare temporal and causal relationships of in PTSD with trauma-exposed control (TEC) non-TEC subjects. Methods T1-weighted magnetic resonance images 27 PTSD, 33 TEC 30 age- sex-matched healthy (HC) studied. network covariance used evaluate the patients. Results Volumes bilateral hippocampal left lingual gyrus significantly smaller patients than...
Remodeling of the extracellular matrix (ECM), which is induced by lysyl oxidase (LOX), has been demonstrated to accompany tumor progression; however, association between LOX expression levels and malignant behavior prostate cancer (Pca) remains unclear. The present study aimed analyze tumor-associated profile in patients with Pca evaluate its potential prognostic value. In form a retrospective study, patterns collagen I were analyzed benign hyperplasia immunohistochemical examination....
With the increasing incidence of colorectal cancer (CRC) and continued difficulty in treating it using immunotherapy, there is an urgent need to identify effective immune-related biomarker associated with survival prognosis patients this disease. DNA methylation plays essential role maintaining cellular function, changes patterns may contribute development autoimmunity, aging, cancer. In study, we aimed a novel methylated signature aid predicting CRC. We investigated stage II/III CRC...
Osteosarcoma is the most common mesenchymal cell malignancy, 10% of which fibroblastic osteosarcoma (FOS). Due to low incidence osteosarcoma, impact many pathological factors on survival still unclear, especially FOS. The goal this study was assess latest rates for FOS and risk affecting using Surveillance, Epidemiology, End Results (SEER) database.
Continuously adapting pre-trained models to local data on resource constrained edge devices is the $\emph{last mile}$ for model deployment. However, as increase in size and depth, backpropagation requires a large amount of memory, which becomes prohibitive devices. In addition, most existing low power neural processing engines (e.g., NPUs, DSPs, MCUs, etc.) are designed fixed-point inference accelerators, without training capabilities. Forward gradients, solely based directional derivatives...
Raised serum glucose-phosphate ratio on admission is associated with severity and poor outcome of aneurysmal subarachnoid hemorrhage severe traumatic brain injury. However, its role in acute ischemic stroke (AIS) remains still unknown. Therefore, this prospective study aimed to investigate the association between 1-year clinical AIS.
Investigate the effect of Nine-in-one-drawing therapy on anxiety, depression, and psychological resilience community correction objects. Sixty cases objects with anxiety depression were randomly divided into experimental group control group, 30 in each group. The conventional methods was adopted Self-Rating Anxiety Scale (SAS), Depression (SDS), Connor-Davidson Resilience (CD-RISC) used to evaluate. In based items Scale, before after intervention two groups for evaluation. activities carried...
This study investigates the correlation between gene polymorphism of rs8192675 (C/C) locus SLC2A2 in patients with type 2 diabetes (T2DM) and efficacy metformin. For this purpose, we have selected 110 T2DM (T2DM group) healthy people (control who were treated our hospital from January 2019 to 2020 as research subjects. PCR-restriction fragment length (PCR-RFLP) method detects distribution frequency polymorphism. The group metformin followed up for 90 days analyze relationship genotypes...