A5100692998- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Ion Transport and Channel Regulation
- Sexual Differentiation and Disorders
- Microbial metabolism and enzyme function
- Mycobacterium research and diagnosis
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Testicular diseases and treatments
- Heat shock proteins research
- Cell death mechanisms and regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Bioactive Natural Diterpenoids Research
- interferon and immune responses
Chinese PLA General Hospital
2011-2024
State Key Laboratory of Kidney Diseases
2017-2024
Dalian Medical University
2014-2020
First Affiliated Hospital of Dalian Medical University
2014-2020
China Medical University
2005-2017
Deregulated microRNAs participate in carcinogenesis and cancer progression, but their roles development remain unclear. In this study, miR-365 expression was found to be downregulated human colon tissues as compared with that matched non-neoplastic mucosa tissues, its downregulation correlated progression poor survival patients. Functional studies revealed restoration of inhibited cell cycle promoted 5-fluorouracil-induced apoptosis repressed tumorigenicity lines. Furthermore, bioinformatic...
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that is involved the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions a tumor suppressor cell (Rcc). However, underlying molecular mechanism Rcc, especially association with miR-217, has not been studied. In this study, we first demonstrated expression upregulated, which correlated progression, miR-217 downregulated Rcc tissues cells....
Abstract Multidrug resistance (MDR) correlates with treatment failure and poor prognosis among breast cancer patients. This study was aimed to investigate the possible mechanism by which microRNA-130b-3p (miR-130b) mediates chemoresistance proliferation of cancer. MiR-130b found be up-regulated in tumor tissues versus adjacent cancer, as well adriamycin (ADR) resistant cell line (MCF-7/ADR) its parental (MCF-7) non-malignant epithelial (MCF-10A), demonstrating crucial relevance for biology....
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. This study aimed to explore prognostic value lncRNAs in CRC.We performed gene expression profiling identify differentially expressed between 51 normal and 646 tumor tissues from The Cancer Genome Atlas database. Cox regression robust likelihood-based survival models were used find prognosis-related lncRNAs. A lncRNA signature was developed predict overall patients with CRC. In addition, a receiver operating...
Tumor metastasis is a major cause of cancer‐related death in renal cell carcinoma (RCC). MicroRNAs (miRNAs) have been widely known to modulate proliferation invasion, metastasis, and apoptosis cancer cells. In this study, we aimed investigate the function novel target miR‐193a‐3p miR‐224 RCC. The levels were significantly increased RCC tissues lines. Alpha‐2,3‐Sialyltransferase IV (ST3GalIV) was highly expressed adjacent nontumor human normal proximal tubular line HK‐2 compared ST3GalIV...
Cancer treatment alters microRNA (miRNA) expression, revealing potential therapeutic targets (oncotarget). Here we treated pancreatic cancer (ASPC-1) cells with either recombinant human endostatin (rh-endostatin) or gemcitabine. Then high-throughput sequencing assay was performed to screen for altered miRNAs. Both treatments decreased levels of MiR-19a. We found that miR-19a stimulated cell proliferation, migration, invasion in vitro and tumor growth vivo. High correlated poor prognosis...
Emerging evidence has indicated that long non‑coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) regulates cell growth, differentiation, apoptosis and cancer progression. However, expression function of HOTTIP in progression renal carcinoma (RCC) remain largely unknown. In this study, we investigated role lncRNA RCC. The levels RCC tissues lines were determined by RT‑qPCR. association between clinicopathological characteristics prognosis was analyzed patients with from TCGA...
It is known that aquaporin 9 (AQP9) in the prostate was strictly upregulated by androgen and may represent a novel therapeutic target for several cancers, but whether AQP9 plays role regulation of androgen-independent cancer still remains unclear. In present study, determined adjacent tissues; AQP9-siRNA applied to silencing cell PC3 line. Western blot flow cytometry analysis were employed detect changes related-function control groups. The results showed significantly induced tissues than...
ABSTRACT Long noncoding RNAs (lncRNAs) have emerged as important regulators of cancer progression. Abnormal sialylation leads to renal cell carcinoma (RCC) malignancy. However, the mechanism by which lncRNA maternally expressed gene 3 (MEG3) mediates RCC progression regulating ST3Gal1 transcription and EGFR is still unrevealed. Here, we found that expression MEG3 was higher in adjacent tissues than tissues, well downregulated lines compared normal cells. The proliferation, migration invasion...
Incidence of melanoma is increasing annually worldwide. There remains a lack suitable treatment methods which can significantly improve the 5-year survival rates patients. It established that micro RNAs (miRNAs) have important roles in diagnosis and cancer. MiR-337 had been reported to regulate development variety cancers, as cancer suppressive factor. In our research we found miR-337 lower expression than adjacent tissues. The patients who also got worse survival. could target STAT3...
Primary extragonadal germ cell tumors are rare, and 60% of such cases seminomas. While the can occur in mediastinum, thymus, retroperitoneal organs pineal gland, seminoma originating prostate tissue is extremely rare. The present study reports case a 54-year-old male with seminoma. patient was followed up at First Affiliated Hospital Dalian Medical University (Dalian, Liaoning, China) from 2001 onwards. received chemotherapy cyclophosphamide following total resection pelvic organs, lymph...
Remodeling of the extracellular matrix (ECM), which is induced by lysyl oxidase (LOX), has been demonstrated to accompany tumor progression; however, association between LOX expression levels and malignant behavior prostate cancer (Pca) remains unclear. The present study aimed analyze tumor-associated profile in patients with Pca evaluate its potential prognostic value. In form a retrospective study, patterns collagen I were analyzed benign hyperplasia immunohistochemical examination....
OBJECTIVE To analyze the effects of interaction between vascular endothelial cells and monocytes on expression matrix metalloproteinase-2 (MMP-2) tissue inhibitor metalloproteinase 2 (TIMP-2), as well regulation pravastatin. METHODS A co-cultured system was established through addition THP-1 to human umbilical vein (HUVECs) in various rates. After 24 hours, changes activity MMP-2 TIMP-2 co-culture were studied by zymography reverse zymography. The 1:1 selected one control group (no...