A5012582985- Renal cell carcinoma treatment
- Pediatric Urology and Nephrology Studies
- Tuberous Sclerosis Complex Research
- Intestinal and Peritoneal Adhesions
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Renal and related cancers
- Congenital Diaphragmatic Hernia Studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Caveolin-1 and cellular processes
- ATP Synthase and ATPases Research
- Bioactive Natural Diterpenoids Research
- Circular RNAs in diseases
- Underwater Vehicles and Communication Systems
- Ovarian cancer diagnosis and treatment
- Inhalation and Respiratory Drug Delivery
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Ion Transport and Channel Regulation
- Carbohydrate Chemistry and Synthesis
Dalian Medical University
2017-2024
First Affiliated Hospital of Dalian Medical University
2017-2024
Older patients with cancer, particularly those over 75 years of age, often experience poorer clinical outcomes compared to younger patients. This can be attributed age-related comorbidities, weakened immune function, and reduced tolerance treatment-related adverse effects. In the checkpoint inhibitors (ICI) era, age has emerged as an influential factor impacting discovery predictive biomarkers for ICI treatment. These age-linked changes in system influence composition functionality...
Stromal cell populations in the tumor microenvironment (TME) play a critical role oncogenesis and metastasis of renal carcinoma. In this study, we found that there are α-smooth muscle actin positive (α-SMA (+)) cells stroma clear carcinoma (ccRCC) tissues, their numbers significantly associated with poor survival ccRCC patients. Interleukin 6 (IL-6) is diver induces α-SMA (+) tissues via promotion epithelial to mesenchymal transition (EMT) stimulates migration invasion ccRCC. Peritumoral...
Recently, long noncoding RNAs have emerged as new gene regulators and prognostic markers in several cancers, including renal cell carcinoma (RCC). Here, we focused on the RNA lung cancer associated transcript 1 (LUCAT1) based clear RCC (ccRCC) genome atlas (TCGA) data. However, whether aberrant expression of LUCAT1 ccRCC is correlated with malignancy, metastasis or prognosis has not been elucidated. In current study, found that was upregulated tissues lines. Upregulated positively larger...
Background: It is anticipated that there will be a large rise in the number of tumor diagnoses and mortality those aged 65 older over course upcoming decades. Immune checkpoint inhibitors, often known as ICIs, boost immune system activity by selectively targeting ICI genes. On other hand, old age may connected with unfavorable results. Methods: The Cancer Genome Atlas (TCGA) provided gene expression data from ccRCC tissue key clinical variables. databases were applied verified using GEO...
To assess the clinical characteristics, radiological predictors, and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria to determine impact adherent (APF) retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes.84 patients undergoing RLPN were included into 4 groups PFAD. Univariate multivariate analyses performed for characteristics predictors Perioperative data compared between APF non-APF groups. Masson staining determined collagen...
This retrospective clinical study is to evaluate the safety and efficiency of two different approaches in retroperitoneal laparoscopic adrenalectomy provide experience basis for treatment adrenal tumors through approach.From July 2015 February 2018, 112 patients with lesions underwent (RLA) using a 3-port method. Among them, 56 RLA via extra perinephric fat approach (EPFA), intra (IPFA). Clinical data, including preoperative, operative postoperative management were recorded.All surgeries...
Background: Clear cell renal carcinoma (ccRCC), the predominant subtype of RCC, is distinguished by unique biological characteristics and heterogeneity, including eosinophilic clear subtypes. Notwithstanding progress in therapy, immune checkpoint inhibitors (ICIs), tyrosine kinase (TKIs), prognosis for individuals with metastatic ccRCC remains poor, presumably owing to metabolic alterations leading mitochondrial dysfunction, which affects treatment response variability. Methods: We analyzed...
Numerous rare urinary tract (UT) cancers lack adequate understanding of survival and therapeutic options, nearly all responses to systemic therapy are unsatisfactory, yet clinical research is scarce.Between 2010 2015, a total (14,622 patients) with uncommon UT cancer (62.5%) in the overall (OS) group (37.5%) specific (CSS)group were identified SEER database. multimodality approach on OS CSS compared.In malignancies, outperformed locoregional stage (P < 0.05), but not distant = 0.34)....
Neurofibromatosis type 1, also known as NF1, is a disorder that passed down in an autosomal dominant manner. It manifests wide variety of tumors and affects several organ systems. expected those carrying the NF1 gene will develop rare mesenchymal tumor gastrointestinal stromal (GIST) more than general population.This research discusses 42-year-old female patient with who was identified duodenal GIST but clinically radiographically misinterpreted having retroperitoneal neurofibroma. She had...
Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria to determine impact adherent (APF) retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes.Methods 84 patients undergoing RLPN were included into 4 groups PFAD. Univariate multivariate analysis performed for characteristics Perioperative data was compared between APF non-APF groups. Masson staining...
Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria to determine impact adherent (APF) retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods 84 patients undergoing RLPN were included into 4 groups PFAD. Univariate multivariate analysis performed for characteristics Perioperative data was compared between APF non-APF groups. Masson staining...
Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria to determine impact adherent (APF) retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods 84 patients undergoing RLPN were included into 4 groups PFAD. Univariate multivariate analysis performed for characteristics Perioperative data was compared between APF non-APF groups. Masson staining...
Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria to determine impact adherent (APF) retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods 84 patients undergoing RLPN were included into 4 groups PFAD. Univariate multivariate analysis performed for characteristics Perioperative data was compared between APF non-APF groups. Masson staining...
Abstract Background: To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria to determine impact adherent (APF) retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods: 84 patients undergoing RLPN were included into 4 groups PFAD. Univariate multivariate analysis performed for characteristics Perioperative data was compared between APF non-APF groups. Masson staining...