Industrial recommender systems have embraced deep learning algorithms for building intelligent to make accurate recommendations. At its core, offers powerful ability representations from data, especially user and item representations. Existing learning-based models usually represent a by one representation vector, which is insufficient capture diverse interests large-scale users in practice. In this paper, we approach the of different view, representing with multiple vectors encoding aspects...

A unique robotic medical platform is designed by utilizing cell robots as the active "Trojan horse" of oncolytic adenovirus (OA), capable tumor-selective binding and killing. The OA-loaded are fabricated entirely modifying OA-infected 293T cells with cyclic arginine-glycine-aspartic acid tripeptide (cRGD) to specifically bind bladder cancer cells, followed asymmetric immobilization Fe3 O4 nanoparticles (NPs) on surface. OA can replicate in host induce cytolysis release virus progeny...

Older patients with cancer, particularly those over 75 years of age, often experience poorer clinical outcomes compared to younger patients. This can be attributed age-related comorbidities, weakened immune function, and reduced tolerance treatment-related adverse effects. In the checkpoint inhibitors (ICI) era, age has emerged as an influential factor impacting discovery predictive biomarkers for ICI treatment. These age-linked changes in system influence composition functionality...

It is vital to differentiate catalytic properties between cationic and metallic single atoms at the atomic level. To achieve this, we fabricated well-defined Ni snugged in supported on monolayered CuO. The cations are chemically inert for CO adsorption even 70 K but highly active toward O2 dissociation room temperature. adsorbed O oxidize incoming molecules from gas phase into CO2, which follows Eley-Rideal mechanism, contrast Mars-van Krevelen mechanism CuO-monolayer-supported as well our...

In this study, single Ni2 clusters (two Ni atoms bridged by a lattice oxygen) are successfully synthesized on monolayered CuO. They exhibit remarkable activity toward low-temperature CO2 thermal dissociation, in contrast to cationic that nondissociatively adsorb and metallic ones chemically inert for adsorption. Density functional theory calculations reveal the can significantly alter spatial symmetry of their unoccupied frontier orbitals match occupied counterpart molecule enable its...

Kidney renal clear cell carcinoma (KIRC), a therapy-resistant aggressive kidney cancer, exhibits resistance to immune checkpoint inhibitors. Altered sialylation is involved in tumor development, affecting microenvironment dynamics. In the study, through systematic bioinformatics analysis and experimental verification, we demonstrated that ST3Gal5 expression was elevated tissues of KIRC patients, correlating with poor prognosis, ST3Gal1 downregulated associated better prognosis....

Industrial recommender systems usually consist of the matching stage and ranking stage, in order to handle billion-scale users items. The retrieves candidate items relevant user interests, while sorts by interests. Thus, most critical ability is model represent interests for either stage. Most existing deep learning-based models one as a single vector which insufficient capture varying nature user's In this paper, we approach problem from different view, with multiple vectors encoding...

Click-Through Rate (CTR) prediction is one of the core tasks in recommender systems (RS). It predicts a personalized click probability for each user-item pair. Recently, researchers have found that performance CTR model can be improved greatly by taking user behavior sequence into consideration, especially long-term sequence. The report on an e-commerce website shows 23\% users more than 1000 clicks during past 5 months. Though there are numerous works focus modeling sequential behaviors,...

Abstract Background New therapeutic drugs are urgently needed against visceral leishmaniasis because current drugs, such as pentavalent antimonials and miltefosine, produce severe side effects development of resistance. Whether cyclosporine A (CsA) its derivatives can be used for has been controversial many years. Methods In this study, we evaluated the efficacy CsA derivative, dihydrocyclosporin (DHCsA-d), promastigotes intracellular amastigotes Leishmania donovani . Sodium stibogluconate...

To construct and validate a deep learning cluster from whole slide images (WSI) for depicting the immunophenotypes functional heterogeneity of tumor microenvironment (TME) in patients with bladder cancer (BLCA) to explore an artificial intelligence (AI) score underlying biological pathways developed WSI cluster.

Background: It is anticipated that there will be a large rise in the number of tumor diagnoses and mortality those aged 65 older over course upcoming decades. Immune checkpoint inhibitors, often known as ICIs, boost immune system activity by selectively targeting ICI genes. On other hand, old age may connected with unfavorable results. Methods: The Cancer Genome Atlas (TCGA) provided gene expression data from ccRCC tissue key clinical variables. databases were applied verified using GEO...

Using the most comprehensive weekly dataset of 'A' shares listed on Chinese stock market, this paper examines short-term contrarian strategies under different market states from 1995–2010. We find statistically significant profits strategies, especially during period after 2007, when China (along with other countries) experienced an economic downturn following worldwide financial crisis. Our empirical evidence suggests that: (1) no profit is generated either momentum or in intermediate...

<title>Abstract</title> Bladder cancer (BC) ranks as the fourth in males and tenth most common worldwide. Conventional treatment modalities, including surgery, radiation, chemotherapy, immunotherapy, have limited efficacy certain advanced instances. The involvement of GALNT6-mediated aberrant O-glycosylation modification several malignancies immune evasion is a subject speculation. However, its significance BC has not been investigated. Through integration bioinformatics analysis laboratory...

Bladder cancer (BCa) is the 10th most prevalent globally. Neoadjuvant therapy has become standard treatment for muscle-invasive bladder cancer, yet pathologic complete response rate patients only approximately 35%. However, mechanisms underlying neoadjuvant resistance in remain unclear. We collected two sets of paired specimens before and after therapy, performed RNA sequencing. The findings revealed a significant decrease IFI27 expression levels post-neoadjuvant group compared to samples...

Deep learning based methods have been widely used in industrial recommendation systems (RSs). Previous works adopt an Embedding&MLP paradigm: raw features are embedded into low-dimensional vectors, which then fed on to MLP for final recommendations. However, most of these just concatenate different features, ignoring the sequential nature users' behaviors. In this paper, we propose use powerful Transformer model capture signals underlying behavior sequences Alibaba. Experimental results...

This research aimed to develop a model for individualized treatment decision-making in inoperable elderly patients with esophageal squamous cell carcinoma (ESCC) using machine learning methods and multi-modal data.A total of 189 ESCC aged 65 or older who underwent concurrent chemoradiotherapy (CCRT) radiotherapy (RT) were included. Multi-task models created techniques analyze data, including pre-treatment CT images, clinical information, blood test results. Nomograms constructed predict the...

Background. Township hospitals in China provide rural communities with basic but much needed critical health care services. The doctors working these often feel unsatisfied when considering their work schedules and financial rewards. Method. To explore job satisfaction of workers a township hospital, qualitative study was conducted 39 from five Guangxi Zhuang Autonomous Region. goal to understand the level make recommendations for improvements. Results. About 75% (28/39) expressed negative...

In recent years, a great deal of efforts has been made to develop objective image quality assessment (IQA) that shows consistency with subjective evaluation. After structure similarity was found be an important factor, IQA metrics such as SSIM showed better performance than traditional ones. With the usage phase congruency (PC) obtain measurement, new metric named FSIM acquired even higher consistency. This paper is motivated propose improved based on FSIM, where quaternion wavelet transform...

According to the feature that small moving target is highly sparse relative sky background in infrared image, a novel adaptive subtraction method was presented. The image sequence can be directly detected by using based on compressive sensing. It also significantly reduce sampling of signal and transmission bandwidth. simulation results indicate proposed effective.