A5041195296- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Pelvic floor disorders treatments
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Renal and related cancers
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Melanoma and MAPK Pathways
- Polyamine Metabolism and Applications
- Urologic and reproductive health conditions
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Clusterin in disease pathology
- Infectious Disease Case Reports and Treatments
- Vascular Tumors and Angiosarcomas
- melanin and skin pigmentation
- Advanced Breast Cancer Therapies
- Heat shock proteins research
First Affiliated Hospital of Dalian Medical University
2020-2025
Dalian Medical University
2020-2025
Older patients with cancer, particularly those over 75 years of age, often experience poorer clinical outcomes compared to younger patients. This can be attributed age-related comorbidities, weakened immune function, and reduced tolerance treatment-related adverse effects. In the checkpoint inhibitors (ICI) era, age has emerged as an influential factor impacting discovery predictive biomarkers for ICI treatment. These age-linked changes in system influence composition functionality...
Kidney renal clear cell carcinoma (KIRC), a therapy-resistant aggressive kidney cancer, exhibits resistance to immune checkpoint inhibitors. Altered sialylation is involved in tumor development, affecting microenvironment dynamics. In the study, through systematic bioinformatics analysis and experimental verification, we demonstrated that ST3Gal5 expression was elevated tissues of KIRC patients, correlating with poor prognosis, ST3Gal1 downregulated associated better prognosis....
Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer, and the therapy options for PDAC remain restricted. The distinctive tumor immunological microenvironment (TIME) of PDAC, comprising high number stromal cells limited infiltration cytotoxic T lymphocytes (CTLs), rendered immunotherapy ineffective. protein level ubiquitin-specific protease 43 (USP43) was prognostic predictor in numerous cancers; however, its function limited. This article focuses on influence USP43 expression...
Background Candida auris ( C. ), a recently developing fungal disease with high virulence, easy transmission, and substantial medication resistance in hospitals, poses growing danger to human health. In 2009, the initial documentation of this was made when it discovered ear canal an elderly Japanese patient. Since its isolation, presence across six continents has been cause for severe concern among medical professionals scientists. According recent findings, is connected five geographically...
Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK family transcription factors that plays an oncogenic or tumor-suppressive role in different cancers depending on type genetic context cancer. However, function molecular mechanism ZBTB7A bladder cancer (BC) remain elusive.The was detected by colony formation, transwell, tumor formation assays. The expression levels ZBTB7A, HIC1, miR-144-3p were analyzed qRT-PCR Western blot. Bioinformatics analysis dual-luciferase...
Background: It is anticipated that there will be a large rise in the number of tumor diagnoses and mortality those aged 65 older over course upcoming decades. Immune checkpoint inhibitors, often known as ICIs, boost immune system activity by selectively targeting ICI genes. On other hand, old age may connected with unfavorable results. Methods: The Cancer Genome Atlas (TCGA) provided gene expression data from ccRCC tissue key clinical variables. databases were applied verified using GEO...
The purpose of this study is to determine the therapeutic value surgery in individuals with urinary bladder signet ring cell carcinoma (SRCC). Surgery has not been examined as a prognostic factor for cancer (SRCC).Using Surveillance, Epidemiology, and End Results program (SEER), patients SRCC who presented from 1975 2018 were included retrospective study. effect surgical therapy on cause-specific survival (CSS) overall (OS) was using univariate multivariate Cox regression models. We...
Abstract To get a better understanding of the genetic basis primary signet ring cell carcinoma (SRCC) bladder, which is highly rare and not yet explored. First, by using immunohistochemistry to find histological pathological characteristics. Second, massively parallel whole‐exome sequencing (WES) was performed on 58‐year‐old male patient who had painless macroscopic hematuria pathologically diagnosed with SRCC followed comparing genes ordinary urothelial cancer (UC) from TCGA. Furthermore,...
Background Tumor-stroma ratio (TSR) and tumor budding (TB) play important roles in muscle-invasive bladder cancer (MIBC). We developed a rating system (TSR-TB type) based on the morphological evaluation of TSR TB for predicting patient outcome using individualized care.Methods were assessed publicly accessible MIBC slides from TCGA database. patients classified as low stromal or high type TSR, was further compartmentalized mixed TB.Results TSR-TB an independent adverse prognostic factor OS...
Cancer diagnoses and deaths among the elderly (65 +) are expected to increase significantly over next decade. Immune checkpoint inhibitors specifically target ICI genes enhance immune system function. However, poor outcomes may be associated with aging.We downloaded Genomic Data Commons from Genome Atlas (TCGA) collected gene expression data malignant melanoma (MM) tissues, third level as primary site. The CKTTD database were applied validated using GEO lab experiments.In 414 patients, 13...
The cardiotoxicity during immunotherapy administration leads to mortality by more than 42% and heart disease-related among immunotherapy-linked cancers is still considered be underestimated. In this study, the advanced stage of non-small cell lung cancer (NSCLC) with death was selected in accordance approval time. NSCLC searched on Surveillance, Epidemiology, End Results (SEER) program. showed that 538 cases, those dominated men elderly people aged 70 years had a high percentage both eras....
Abstract Background Lung adenocarcinoma (LUAD) remains one of the world’s most known aggressive malignancies with a high mortality rate. Molecular biological analysis and bioinformatics are great importance as they have recently occupied large area in studies related to identification various biomarkers predict survival for LUAD patients. In our study, we attempted identify new prognostic model by developing algorithm calculate allele frequency deviation (AFD), which turn may assist early...
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Background: Clear cell renal carcinoma (ccRCC), the predominant subtype of RCC, is distinguished by unique biological characteristics and heterogeneity, including eosinophilic clear subtypes. Notwithstanding progress in therapy, immune checkpoint inhibitors (ICIs), tyrosine kinase (TKIs), prognosis for individuals with metastatic ccRCC remains poor, presumably owing to metabolic alterations leading mitochondrial dysfunction, which affects treatment response variability. Methods: We analyzed...
Background: Recent evidence suggests a crucial biological role for Circular RNAs (circRNAs) in keloid diseases, yet the underlying mechanisms remain unclear.This study explored effects and molecular of hsa_circ_0002198 formation.Methods: Real-time quantitative PCR (qRT-PCR) was employed to assess expression circ_0002198 tissues, normal skin fibroblasts (KFs), (NFs) from nine patients.To investigate pathogenesis, cell transfection technology utilized knock down circ_0002198.Various...