A5102822220- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Energy and Environmental Sustainability
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Digital Transformation in Law
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Pancreatitis Pathology and Treatment
- Plant chemical constituents analysis
- Protein Degradation and Inhibitors
- Berberine and alkaloids research
Dalian Medical University
2015-2024
First Affiliated Hospital of Dalian Medical University
2015-2024
Shanghai Sixth People's Hospital
2021
Shanghai Jiao Tong University
2021
East China University of Science and Technology
2020
Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as key regulator for fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated receptor gamma (PPARγ) through K48-linked deubiquitination, turn, this stabilization increases acetyl-CoA carboxylase (ACC) ATP citrate lyase (ACLY) expressions. In addition, find that...
Unpredictable in vivo therapeutic feedback of hydroxyl radical (. OH) efficiency is the major bottleneck chemodynamic therapy. Herein, we describe novel Fenton-based nanotheranostics NQ-Cy@Fe&GOD for spatio-temporally reporting intratumor . OH-mediated treatment, which innovatively unites dual-channel near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces dose distribution iron oxide nanoparticles (IONPs) with high-spatial resolution,...
Abstract Background The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate interactions cells with extracellular matrix (ECM) promote tumorigenesis in several malignancies. However, role ITGB5 hepatocellular carcinoma (HCC) still unknown. Methods biological function HCC was investigated using migration, colony formation assays. potential molecular mechanism regulating β-catenin...
Resistance to platinum-based chemotherapy is one of the most important reasons for treatment failure in advanced non-small cell lung cancer, but underlying mechanism extremely complex and unclear. The present study aimed investigate correlation ubiquitin-specific peptidase 22 (USP22) with acquired resistance cisplatin adenocarcinoma. In this study, we found that overexpression USP22 could lead A549 cells. its downstream proteins γH2AX Sirt1 levels are upregulated cisplatin- resistant...
This study evaluated the prognostic significance of preoperative neutrophil to lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR) and tumor-infiltrating lymphocytes (TILs), whether these blood inflammatory indicators were associated with TILs in hilar cholangiocarcinoma (HCCA).A total 76 patients HCCA who underwent radical resection included. Data on their clinicopathologic characteristics, perioperative features, survival outcomes analyzed. The optimal cutoff levels for NLR, PLR LMR...
Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution hepatocellular carcinoma (HCC) is currently unknown. The aim this study was evaluate prognostic value TRIM16 and investigate functional roles in HCC. expression HCC patient samples were examined using qRT-PCR western blotting. cell lines with either...
Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer, and the therapy options for PDAC remain restricted. The distinctive tumor immunological microenvironment (TIME) of PDAC, comprising high number stromal cells limited infiltration cytotoxic T lymphocytes (CTLs), rendered immunotherapy ineffective. protein level ubiquitin-specific protease 43 (USP43) was prognostic predictor in numerous cancers; however, its function limited. This article focuses on influence USP43 expression...
Abstract Acute pancreatitis (AP) is a common acute abdominal condition of the digestive system. In recent years, treatment concepts, methods, and strategies for diagnosis AP have advanced, this has played an important role in promoting standardization improving quality patients. On basis previous guidelines expert consensus, guideline adopts evidence-based, problem-based expression; synthesizes clinical research data at home abroad most 5 years; forms 29 recommendations through...
Objective . This study is to investigate the role of CIKs cocultured with K-ras-DCs in killing pancreatic cancer cell lines, PANC-1 (K-ras + ) and SW1990 − ). Methods induced by IFN- γ , IL-2, anti-CD3 monoantibody, K-ras-DCCIKs obtained cocultivation k-ras-DCs CIKs. Surface markers examined FACS. IL-12 ,CCL19 CCL22 detected ELISA. Proliferation various tested via 3H-TdR. Killing activities k-ras-DCCIKs CTLs 125IUdR. Results CD3 CD56 CD8 were highly expressed K-ras-DCCIKs. In its...
Hepatocellular carcinoma (HCC) displays a high degree of metabolic and phenotypic heterogeneity has dismal prognosis in most patients. Here, gas chromatography-mass spectrometry (GC-MS)-based nontargeted metabolomics method was applied to analyze the profiling 130 pairs hepatocellular tumor tissues matched adjacent noncancerous from HCC A total 81 differential metabolites were identified by paired nonparametric test with false discovery rate correction compare tissues. Results demonstrated...
Abstract Unpredictable in vivo therapeutic feedback of hydroxyl radical ( . OH) efficiency is the major bottleneck chemodynamic therapy. Herein, we describe novel Fenton‐based nanotheranostics NQ‐Cy@Fe&GOD for spatio‐temporally reporting intratumor OH‐mediated treatment, which innovatively unites dual‐channel near‐infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces dose distribution iron oxide nanoparticles (IONPs) with high‐spatial...
The identification of mutated genes in glioblastoma multiforme (GBM) is an essential step towards improving current understanding the molecular mechanism underlying disease and establishing novel targets for diagnostic therapeutic purposes. present study used direct sequencing to screen 20 malignancy-associated genes, which have either been well described literature or observed multiple times human cancer sequencing, cancerous normal control tissue samples from patients with histologically...
With a poor prognosis and lack of effective therapies, pancreatic cancer is one the most deadly tumors. The early diagnosis particularly important to improve patients’ survival rates. In present study, leveraging on targeted binding asparagine-glycine-arginine (NGR) peptides CD13, which overexpressed cells, we constructed nanoparticles, termed QDs-NGR, explored fluorescence imaging influence at cellular level in vitro these nanoparticles. QDs-NGR nanoparticles enabled compared with QDs...
The elevated expression of urokinase-type plasminogen activator receptor (uPAR) is associated with the poor prognosis pancreatic cancer patients. Thus, uPAR a promising candidate as molecular target for non-invasive imaging cancer. present study aimed to develop technetium-99m (99mTc)-labeled uPAR-binding peptide single-photon emission computed tomography (SPECT) assessment in xenograft models. A linear high-affinity antagonist, Hynic-PEG-AE105, was labeled 99mTc. Human uPAR-positive BxPC-3...