A5061530426- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Colorectal Cancer Treatments and Studies
- Polyomavirus and related diseases
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Colorectal Cancer Screening and Detection
- Digestive system and related health
- Immunodeficiency and Autoimmune Disorders
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Colorectal Cancer Surgical Treatments
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
Chinese PLA General Hospital
2018-2023
Tsinghua University
2023
State Key Laboratory of Biotherapy
2015
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. This study aimed to explore prognostic value lncRNAs in CRC.We performed gene expression profiling identify differentially expressed between 51 normal and 646 tumor tissues from The Cancer Genome Atlas database. Cox regression robust likelihood-based survival models were used find prognosis-related lncRNAs. A lncRNA signature was developed predict overall patients with CRC. In addition, a receiver operating...
Abstract Gastric cancer, like most of other cancers, has an uncontrolled cell cycle regulated by cyclins and cyclin-dependent kinases (CDKs). In this study, we reported that gastric cancer cells showed accelerated G2/M transition promoted CREPT/RPRD1B Aurora kinase B (Aurora B). We found were coordinately expressed during the in cells. Deletion disturbed progression extended length cycle, leading to a significant accumulation mitotic Mechanistically, revealed interacted with regulate...
Abstract Intestinal stem cells (ISCs) residing in the crypts are critical for continual self-renewal and rapid recovery of intestinal epithelium. The regulatory mechanism ISCs is not fully understood. Here we report that CREPT, a recently identified tumor-promoting protein, required maintenance murine ISCs. CREPT preferably expressed but villi. Deletion epithelium mice (Vil-CREPT KO ) results lower body weight slow migration epithelial intestine. Vil-CREPT intestine fails to regenerate after...
Background: Aberrant DNA methylation is a crucial epigenetic regulator that closely related to the occurrence and development of various cancers, including breast cancer (BC). The present study aimed identify novel methylation-based prognosis biomarker panel by integrally analyzing gene expression patterns in BC patients. Methods: data (BRCA) were downloaded from Cancer Genome Atlas (TCGA). R packages, ChAMP, SVA, MethylMix, applied unique methylation-driven genes. Subsequently, these genes...
Gastric cancer is one of most common cancers worldwide. Studies have shown that small nucleolar RNAs(snoRNAs) play important roles in several cancers. In this study, we analyzed the snoRNAs were differentially expressed between gastric tumors and normal tissues, identified survival-associated snoRNAs, developed an eight-snoRNA signature to predict overall survival patients with cancer. Furthermore, explored clinical significance eight snoRNAs. The risk biomarker established by snoRNA was...
Abstract Background Signal transducer and activator of transcription 3 (STAT3) has been shown to upregulate gene during tumorigenesis. However, how STAT3 initiates remains be exploited. This study is reveal the role CREPT (cell cycle-related elevated-expression protein in tumours, or RPRD1B) promoting transcriptional activity. Methods BALB/c nude mice, overexpression deletion cells were employed for assay tumour formation, chromatin immunoprecipitation, transposase-accessible using...
Abstract Background The incidence of colorectal cancer increases with aging. Curative-intent surgery based on a minimally invasive concept is expected to bring survival benefits elderly patients (aged over 80 years) who are frequently fragile health status and advanced tumors. study explored outcomes in this patient population received robotic or laparoscopic aimed identify an optimal surgical option for those patients. Methods We retrieved the clinical materials follow-up data carcinoma our...
Kuang YS performed the majority of experiments and analyzed data; Wang Y contributed significantly to staining
Rationale: Cancer local recurrence increases the mortality of patients, and might be caused by field cancerization, a pre-malignant alteration normal epithelial cells.It has been suggested that cancer-derived small extracellular vesicles (CDEs) may contribute to but underlying mechanisms remain poorly understood.In this study, we aim identify key regulatory factors within recipient cells under instigation CDEs.Methods: In vitro experiments were performed demonstrate CDEs promote expression...
Immunotherapy is considered as a powerful and promising clinical approach for the treatment of gastric cancer (GC). However, it still challenging to precisely screen patients who potentially benefit from immune checkpoint therapy (ICT). Identification potential biomarkers selecting sensitive immunotherapy was urgently needed.Public sequence data corresponding were used explore immunotherapy.We found that CSMD1 most frequently mutated gene its mutation highly correlated with prognosis in...
Background: Immunodeficiency diseases (IDDs) are associated with an increased proportion of cancer-related morbidity. However, the relationship between IDDs and malignancy readmissions has not been well described. Understanding this could help us to develop a more reasonable discharge plan in special tumor population. Methods: Using Nationwide Readmissions Database, we established retrospective cohort study that included patients 16 most common malignancies, defined two groups:...