A5083380820- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Management of metastatic bone disease
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Epigenetics and DNA Methylation
- Ophthalmology and Visual Impairment Studies
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Neonatal Respiratory Health Research
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Retinopathy of Prematurity Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Cancer Genomics and Diagnostics
Second Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2018-2025
Tianjin University of Traditional Chinese Medicine
2025
Chinese Medical Center
2025
Chinese PLA General Hospital
2016-2024
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Qiqihar Medical University
2020-2024
Beijing National Laboratory for Molecular Sciences
2024
Chinese Academy of Sciences
2024
Concurrent chemoradiotherapy (CCRT) is effective in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, whether outcomes adenocarcinoma are equivalent to SCC after CCRT has been a topic debate. Medical records cancer patients treated with definitive radiotherapy or our institute from January 2011 December 2014 were reviewed. Patients intensity modulated radiation therapy combined intracavitary brachytherapy. Weekly cisplatin was first line regimen concurrent...
// Jie Ming 1, * , Shengnan Ruan Mengyi Wang 1 Dan Ye Ningning Fan 2 Qingyu Meng 3 Bo Tian 4, 5 Tao Huang Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University Science Technology, Wuhan 430022, P.R. China Luoyang Central Zhengzhou University, Luoyang, Henan 471009, Radiation Oncology, Peking College hospital, Beijing 100730, 4 Neurobiology, 430030, Key Laboratory Neurological Diseases Hubei Province, These authors have contributed equally to...
Concurrent chemoradiotherapy (CCRT) is the standard treatment for local advanced cervical cancer. However, elderly patients, studies are limited and outcomes controversial. We retrospectively analyzed efficacy tolerance of radical radiotherapy (RT) or CCRT in cancer patients performed comparisons between them. (≥70 years old) treated with RT January 2006 December 2014. For external beam radiotherapy, 50Gy 25 fractions 50.4Gy 28 were delivered via 3-dimensional conformal radiation therapy...
Platycodin D (PLD) is a saponin found in Platycodon grandiflorum, which has been reported to have anti-inflammatory effects. However, the effects of PLD on ulcerative colitis (UC) remain unknown. In this study, showed potential reduce inflammation, ameliorate intestinal damage, and maintain integrity DSS-induced colitis. beneficial effect was reduced when macrophages were depleted, indicating key role Meanwhile, we that inhibited expression M1 markers promoted M2 colon. Similarly,...
Although overall downregulation of microRNAs (miRNAs) is a general feature clear‐cell renal cell carcinoma (ccRCC), several miRNAs are consistently upregulated, among which miR‐122 was markedly increased in ccRCC tissues. Our study aims to determine the functional importance and underlying mechanism metastasis. Here, we demonstrate that expression tissues, higher found tissues with metastatic disease than those without The levels were associated poor metastasis‐free survival patients...
Atherosclerosis (AS) is a chronic inflammatory disease involving blood vessels. Inflammation affects different cells and increases the expression of adhesion molecules. Morin hydrate (MO) naturally occurring bioflavonoid with anti-inflammatory anti-oxidant effects. Although exact mechanism has not been fully elucidated, MO possibly influences autophagy pathways in immunity inflammation. In this study, showed potential to inhibit atherosclerotic promote vascular endothelial apolipoprotein E...
Kaixinsan (KXS) shows potential in treating cognitive dysfunction and can regulate the gut-brain axis. However, its effective components remain unclear. In this study, of KXS extract distributed serum, brain, heart, liver, lung, kidney, ileum were detected. By analyzing number concentration identified different tissues, active obtained. Then, screened confirmed by evaluating their ability to inhibit Aβ25-35-induced neuronal apoptosis SH-SY5Y cells. Finally, Ginsenoside Rg1, Ro, α-asarone,...
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide, characterized by its progressive and irreversible nature. Early diagnosis crucial for delaying disease progression optimizing treatment strategies. Existing diagnostic methods face limitations in asymptomatic screening often rely on subjective judgment experienced rheumatologists, restricting their application early clinical diagnosis. To address these challenges, we developed an innovative approach...
The aim of the study was to evaluate efficacy and toxicity prophylactic extended-field radiation therapy (RT) for cervical cancer patients treated with concurrent chemoradiotherapy (CCRT).Records without para-aortic metastatic lymph nodes who were definitive RT or CCRT between January 2011 December 2014 reviewed. Patients classified into pelvic groups. An additional dose 50.4 Gy in 28 fractions delivered node regions group. Cox regression propensity-score matching (1:1) used compare overall...
Abstract Hepatocellular carcinoma (HCC) is a common liver malignancy worldwide accompanying with the high rate of recurrence. Accumulating reports have documented significance circular RNAs (circRNAs) in carcinogenesis and development HCC. This study aimed to establish mechanism underlying circ‐HOMER1 involvement To this end, we identified binding site for miR‐1322 via bioinformatics, quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR), dual‐luciferase reporter assays...
AIM: To investigate changes of choroidal thickness (ChT) in children with myopia and the effect current control interventions on ChT. METHODS: Major literature databases were searched for studies relevant to children. All used swept-source optical coherence tomography (SS-OCT) or enhanced depth imaging (EDI-OCT) measure ChT value. The weighted mean difference (WMD) 95% confidence interval (CI) pooled evaluate RESULTS: A total 11 eligible articles, including 1693 myopic 1132 non-myopic eyes,...
Abstract This retrospective study was designed to investigate the heterogeneity of patients with cervical cancer in stage IIIC1 (the 2018 International Federation Gynecology and Obstetrics staging system, FIGO) conduct a risk stratification for this group patients. We reviewed clinical records 325 treated definitive concurrent chemoradiotherapy our institute between January 2008 December 2014. The median follow-up duration 28.4 months (range: 1.9–114.2 months). 3-year DFS eligible 66.3%....
Abstract Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and spermidine-mediated eIF5A hypusination (eIF5A hpu ) appears to be essential most eIF5A’s biological functions, including its important role regulating cancer cell proliferation, epithelial–mesenchymal transition (EMT), stem (CSC) properties as well immune functions. Here we investigated the growth oral squamous carcinoma cells (OSCCs) OSCC-induced polarization M2-like tumor-associated macrophages...
Objective To construct nomograms predicting survival and patterns of failure in patients with cervical cancer treated concurrent chemoradiotherapy (CCRT). Methods A total 833 definitive radiotherapy or CCRT our institute from January 2011 to December 2014 were included. Cox proportional hazard regression models used univariate multivariate analysis. The following variables included the analysis: histology, FIGO stage, lymph node metastases (para-aortic, pelvic, common iliac, binary iliac...
To investigate the role of N6-methyladenosine (m6A) RNA modification in pathogenesis Graves' ophthalmopathy (GO). Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without were used. The global m6A levels specimens determined using an methylation quantification kit. sequencing (RNA-seq) was used to analyze molecules involved regulation differential expression mRNAs between two groups (4 eyes, respectively). genes evaluated by real-time PCR. functional implications...
Objective: To identify the predictors of distant metastasis in patients with cervical cancer treated definitive radiotherapy and develop a model for predicting metastasis. Methods: We reviewed clinical records (IMRT) at Peking Union Medical College Hospital between January 2011 December 2015. Eligible were randomly assigned into development cohort validation 2:1 ratio. Distant rate (DMR) was calculated Kaplan-Meier method. Univariate multivariate analyses using cox proportional hazard...
Considering internal organ motion and tumor regression, it is controversial to use intensity-modulated radiation therapy (IMRT) in definitive radiotherapy for cervical cancer. In this study, we evaluated the efficacy toxicity of IMRT combined with dose-escalated intracavitary brachytherapy (ICBT) total, 373 consecutive FIGO-stage-IIB cancer patients treated ICBT concurrent chemotherapy were included study. A dose 50.4 Gy 28 fractions was delivered pelvis IMRT. Weekly cone-beam computed...
The new staging system of cervical cancer issued in 2018 by the International Federation Gynecology and Obstetrics (FIGO), calls for a evaluation efficacy prophylactic extended field irradiation (EFI) concomitant chemoradiotherapy/brachytherapy treatment locally advanced patients (stage IIIB).We performed retrospective study consisting 133 FIGO IIIB treated Peking Union Medical College Hospital from 2002 to 2010. were distributed two groups depending whether they with EFI or pelvic only...
To validate the 2018 revised FIGO cervical cancer staging system for stage III patients with a cohort from China.Patients (FIGO 2018) treated definitive radiotherapy at our institute were reviewed. Each patient was evaluated both 2014 and systems. Disease-free survival (DFS) calculated Kaplan-Meier method. Receiver operative characteristic (ROC) curves predictive accuracy of DFS in according to different systems created.Between January 2008 December 2014, total 586 IIIC (2018) institute. The...
Rheumatoid arthritis (RA) is a highly disabling autoimmune disorder, characterized by the proliferation of Fibroblast-like Synoviocytes (FLSs). Icariin prenylated flavonol glycoside extracted from medical plant Epimedium, which can inhibit and migration FLSs. However, potential mechanism icariin to alleviate RA remains unclear. In this study, inhibited FLSs in concentration-dependent manner, inducing G2/M phase arrest apoptosis. reduced mitochondrial transmembrane potential, upregulated...
Abstract Targeted drug decisions in metastatic renal cell carcinoma are exclusively made on the basis of clinical criteria. We investigated whether these biomarkers (HIF-1α, HIF-2α, CAIX, VEGF, VEGFR1, VEGFR2, VEGFR3, PDGFB, PDGFRA, PDGFRB, CD31, CD44, bcl-xL, KIT, p21, CXCR4, PTEN, (CSF)-1R, RET, and FLT-3) can predictive different effects between sunitinib sorafenib treatments available to guide targeted selection. enrolled all patients who underwent nephrectomy with postoperative...