A5054943922- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Medicinal Plant Pharmacodynamics Research
- Circular RNAs in diseases
First Hospital of Jilin University
2021-2022
Jilin University
2021-2022
Prevention and treatment of atherosclerosis (AS) by targeting the inflammatory response in vascular endothelial cells has attracted much attention recent years. Laminar shear stress (LSS) well-recognized anti-AS properties, however, exact molecular mechanism remains unclear. In this study, we found that LSS could inhibit increased expression intercellular adhesion molecule-1 (ICAM-1), cell (VCAM-1), cyclooxygenase-2 (COX-2), matrix metallopeptidase-9 (MMP-9) caused TNF-α an...
Rheumatoid arthritis (RA) is a highly disabling autoimmune disorder, characterized by the proliferation of Fibroblast-like Synoviocytes (FLSs). Icariin prenylated flavonol glycoside extracted from medical plant Epimedium, which can inhibit and migration FLSs. However, potential mechanism icariin to alleviate RA remains unclear. In this study, inhibited FLSs in concentration-dependent manner, inducing G2/M phase arrest apoptosis. reduced mitochondrial transmembrane potential, upregulated...
ABSTRACT Laminar shear stress (Lss) is an important anti-atherosclerosis (anti-AS) factor, but its mechanism network not clear. Therefore, this study aimed to identify how Lss acts against AS formation from a new perspective. In study, we analyzed high-throughput sequencing data static and Lss-treated human aortic umbilical vein endothelial cells (HAECs HUVECs, respectively) found that the expression of CX3CL1, which target gene closely related development, was lower in group. alleviated...