A5103349537- Immune Cell Function and Interaction
- Bone fractures and treatments
- Advanced Bandit Algorithms Research
- Recommender Systems and Techniques
- Chemotherapy-induced organ toxicity mitigation
- Blood properties and coagulation
- Pharmacological Effects of Natural Compounds
- Andrographolide Research and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Chronic Myeloid Leukemia Treatments
- Cytokine Signaling Pathways and Interactions
- Data Stream Mining Techniques
- Sepsis Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
Sichuan University
2024-2025
University of Science and Technology of China
2024
Jilin Medical University
2021
Jilin University
2021
Chinese PLA General Hospital
2018
Background Isatidis Folium , a botanical drug widely used in traditional medicine, is known for its anti-inflammatory properties, including heat-clearing, detoxifying, and blood-cooling effects. Although potential sepsis treatment has been suggested, the bioactive metabolites underlying mechanisms remain poorly understood. Methods Network pharmacology molecular docking were employed to identify therapeutic effects of Indirubin, major metabolite treatment. In vivo cecal ligation puncture...
The diversity of recommendation is equally crucial as accuracy in improving user experience. Existing studies, e.g., Determinantal Point Process (DPP) and Maximal Marginal Relevance (MMR), employ a greedy paradigm to iteratively select items that optimize both diversity. However, prior methods typically exhibit quadratic complexity, limiting their applications the re-ranking stage are not applicable other stages with larger pool candidate items, such pre-ranking ranking stages. In this...
Rheumatoid arthritis (RA) is a highly disabling autoimmune disorder, characterized by the proliferation of Fibroblast-like Synoviocytes (FLSs). Icariin prenylated flavonol glycoside extracted from medical plant Epimedium, which can inhibit and migration FLSs. However, potential mechanism icariin to alleviate RA remains unclear. In this study, inhibited FLSs in concentration-dependent manner, inducing G2/M phase arrest apoptosis. reduced mitochondrial transmembrane potential, upregulated...